Catch Moffitt’s Todd Knepper, PharmD, tomorrow at #EHA2026, where he will share new research during the Stem Cell Transplantation - Clinical 1 session, examining how post-transplant molecular surveillance can reveal distinct clinical trajectories associated with donor-derived clonal hematopoiesis. #MoffittEHA2026 @EHA_Hematology
CONGRESS | #ASCO26 | PRESENTATION
Shannon Maude shares findings from the primary analysis of a phase II trial (COG AALL1721/CASSIOPEIA), in collaboration with COG, of tisagenlecleucel (tisa-cel) in pediatric and young adult patients (1-25 years of age) with high-risk (HR) B-cell ALL and MRD at the end of frontline consolidation (N = 121).
Median time from infusion to last follow-up was 38 months. The primary end point was met; 4-year OS was 85%. Estimated 5-year DFS with and without censoring was 62% and 64%, respectively. 48% of patients received new anticancer therapy/SCT without prior relapse. Median duration of B-cell aplasia was 5.6 months. Grade ≥3 CRS and ICANS occurred in 2% and 1% of patients, respectively.
Durable remissions and low rates of Grade ≥3 CRS and ICANS were observed with tisa-cel in very HR patients with B-cell ALL. Longer follow-up is needed to confirm the 5-year DFS.
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#ALLsm #leusm #MedNews #MedEd #MedicalCongress @ChildrensPhila
During the last morning poster session at #ASCO26, Kriti Gera, MD (@kriti_gera_), shares research comparing lymphodepletion strategies before CD19 CAR-T therapy, highlighting findings that suggest a potentially safer approach without compromising efficacy for patients with B-cell acute lymphoblastic leukemia. #MoffittASCO26
New publication 📝 5-year follow-up results from the ZUMA-2 trial, published in the Journal of Hematology & Oncology, show brexu-cel produced durable responses in R/R MCL, with a median DoR of 36.5 months.
Learn more: https://t.co/DNvS3ZXgX6
#lymsm#MedNews#MedEd
New #JITC article: "Clinical outcomes and spatial transcriptomic profiles of CD19/20 CAR-T therapy in relapsed or refractory B-cell non-Hodgkin’s lymphoma" https://t.co/yUTvCaz3OI
We recently spoke with @LancetJeff of @MoffittNews to gain insight into the updated ASH guidelines for the management of older patients with newly diagnosed AML.🩸
In this video, Dr Lancet discusses how to decide which patients should be offered antileukemic therapy:
🎥 https://t.co/UDaG7RuMtX
#Leusm #Leukemia #AMLsm #HemOnc
At the International Workshop on CAR-T and Bispecifics (#iwCART26), Moffitt’s Bijal Shah, MD, presented on where CAR T-cell therapy in B-ALL is headed next.
His talk highlighted how today’s CAR T therapies are already outperforming commercial alternatives while the field continues to move toward “CAR 2.0.”
Dr. Shah explored the next generation of CAR strategies, including improved access, dual-antigen targeting, T-cell engineering, cytokine armoring, metabolic resilience and targeted insertion — all aimed at making CAR T-cell therapy more durable, accessible and effective for patients.
🚨🔥 BIG NEWS | #ICETCongress 2026 🔥🚨
Get ready, Orlando! 🌴
📍 Orlando, FL
🗓 July 18, 2026
The National ICE-T Congress is back—bigger, bolder, and pushing the future of #CellTherapy forward 🚀
⭐ Led by powerhouse chairs: @heMEGirl_MD@HemSandoval and ICE-T Executive Director:@kczmj
⚡ CAR-T
⚡ Bispecifics
⚡ Real-world innovation
⚡ Multidisciplinary impact
This is where the future of hematology meets action. Don’t miss it.
@NausheenAhmedMD Jennifer DeVore
🚨 PSA: there is an organized hacking effort going on targeting medical accounts on X/Twitter . 3 of my friends were hacked. If U get a DM from someone U know asking U to click on a link & vote for them for an ambassador program, DO NOT click. Report the account.
In this week's issue of @BloodPortfolio, our study of global access to CAR T, led by Alex Ge.
Thanks to Blood editors for making it a plenary paper!
Free access link: https://t.co/0H4HwFGL3V
Thanks @kjmeetswrld for the thoughtful commentary
https://t.co/5jPIl0h2Mm
@HemSandoval I think we could say that about nearly every pharma sponsored trial that is published - so some nuance to this. Again, I don’t think we should abandon scrutiny (be it clinical retro data or a phase 3) - but I don’t agree that it means inherent bias