Burhan

Resident Psychiatrist, Car and finance enthusiast, hoping to fix what modern medicine can’t

[drMAWZ @TheDrMAWZ]

Back in March I ran a 14 day n=1 on oral Epitalon. Now I get to run it the other way.

Excited to partner with @BeyondWhoosh, physician prescribed & pharmacy compounded peptides. Rx only.

Injectable Epitalon mimics your pineal gland's own peptide to support melatonin production, improve sleep, telomere health & HRV.

Same molecule, subcutaneous instead of oral. Let's see how it compares, tracked & ill document it publically like always.

Code drMAWZ takes 10% off: https://t.co/MfATMgjpzc #ad

[Abud Bakri MD @AbudBakri]

High dose melatonin and T3 are everything SS-31and Mot-c wish they were

[Dalton (Analyze & Optimize) @Outdoctrination]

The lymph massage has changed lives

[Camus @newstart_2024]

To fall asleep you first have to forget where your body is.

Andrew Huberman explained that one of the key steps into sleep is losing track of body position. An old technique that circulated years ago involved slowly moving the eyes side to side, then in circles, then toward the nose while exhaling. He tried it and often woke up the next morning without remembering the transition.

A pair of researchers at MIT later built on the same idea with a sleep mask that gently stimulates the muscles behind the ears, creating the eye movements for you. Huberman said it can drop people into sleep in under six minutes. You feel a light twitch at first, adjust it, and then the eyes simply start moving on their own. He has no financial relationship with the company.

A simple physiological lever most of us never think about.

[Dalton (Analyze & Optimize) @Outdoctrination]

Progesterone has a intelligence increasing effect.

Giving several hundred mg progesterone to pregnant mothers increased their children’s intelligence across the board.

They started walking earlier, and even had better craft skills.

Low progesterone in pregnant mothers has been consistently shown to be a risk factor for autism.

Animal studies confirm that depriving progesterone induces autism.

[Dr. Thomas Ichim @exosome]

How BPC157 works
https://t.co/tTH7IVIaKa

[Ethan Hays @ethanhays]

absolutely mind-boggling thread if you're into muscle physiology & mitochondria

1. weight training makes your muscle genetically more similar to a young person's

• More than half the molecular signature of muscle aging was absent in trained older adults. Specifically, 57.1% of age-related gene downregulation and 55.9% of upregulation were missing in the trained group. Their muscle resembled young adults far more than their chronological age would predict.

2. aging is an "energy crisis", weight training maintains youthful levels in mitochondria

• The changes training preserved were specifically the energy metabolism ones. Genes like NDUFS1 and COX5A, which were depleted in normally active and impaired older adults, sat at youthful levels in the trained group across all five mitochondrial respiratory complexes. The single most prominent feature of muscle aging turned out to be the single most preventable.

3. Structured weight training is required

• Being generally active was not enough. Structured training was the difference. The normally active older adults walked as much as young adults, and their energy metabolism genes declined anyway. What preserved the youthful molecular profile was structured, sustained training. Filling a step counter and being genuinely trained are not equivalent at the molecular level.

[Abud Bakri MD @AbudBakri]

Someone said this is the Ray Peat guide to Looksmaxxing and male aging

Time and stress tries to drag you to the top left corner

Some guys end up their faster than others

[Abud Bakri MD @AbudBakri]

Now this is going to be a fun one

Tune in tmmrw guys

[Abud Bakri MD @AbudBakri]

Khavinson’s work on retina peptides was the most striking thing he did

This is especially important in a world where your photoreceptors are being ravaged by <450nm short wavelength blue light

[Abud Bakri MD @AbudBakri]

In 2 minutes I logged by n=1 epithalon experience on https://t.co/J9HcGlAmlT

If we had been doing this for the past 10 years, we would have millions of data points

if you want peptides to be taken seriously... you know what to do

[Jamal Dinkoui @BerbarianWizard]

Doc, since low T4/T3, sleep deprivation, cold exposure, low energy, stress and circadian disruption can all push TSH up, it always comes back to the same basic things: enough food/carbs, good sleep, morning light, sun exposure to support the melanin pathway, less blue light at night and low prolactin (HI GOONERS) so tyrosine hydroxylase can do its job properly for dopamine too

[Abud Bakri MD @AbudBakri]

Blue light available from wake-up until sleep for 16 hours -> brain thinks it’s summer all day

Summer biology results in MSH up regulating fertility

But… with no ocular UV exposure this doesn’t happen

So you don’t get the high melatonin of winter nor the hormonal boost of summer

Worst of both

[Abud Bakri MD @AbudBakri]

The dance between MSH and TSH is regulating your mood and energy levels and no one is talking about it…

MSH: tyrosine into melanin (day phase)
TSH: tyrosine into thyroxine (night phase)

The fate of tyrosine needs to be calibrated to a 24 hour clock

That’s why the UVA bulbs led to high energy and good mood in that Chicago restaraunt

High day time TSH = sleepy and tired

Also likely = can’t tan = more UV damage

Is the sun the problem or are you just lost in time?

[Andrew D. Huberman, Ph.D. @hubermanlab]

I learned from @AbudBakri
You’re allowed to ask your MD who prescribes a GLP or other peptide what they buy them for and/or if they receive any compensation (monetary or otherwise from the manufacturer). The price ranges for consumers are enormous, in part due to this margin.

[Goku @ProjectGokuu]

Dr. Bakri says if your son is asking about peptides at 18, tell him to stop.

Young guys keep walking up to him in the gym asking where to buy.

• Young bodies make these freely
• Levels drop only with age
• A vial can't beat youth

His answer never changes.

At 18 the body already makes more of these healing peptides than any vial can deliver. Your son is the young animal everyone older is trying to copy.

"Dude, you're 18, you have all the peptides you need in you."

He points to the parabiosis studies.

Young blood is rich with the exact factors older people chase. The kid asking already has them flooding his system.

He'd be paying for what his own body already floods him with for free.

— Dr. Abud Bakri (.@AbudBakri) on the Huberman Lab podcast (.@hubermanlab)

[Abud Bakri MD @AbudBakri]

Circadian rhythm before supplement

https://t.co/cMerEqgCHE

[Max Marchione @maxmarchione]

The strangest part of BPC-157 is that the parent protein was only ever partially sequenced, so the full thing has never been published.

Your body (allegedly) makes the parent protein (BPC), but not BPC-157 itself.

And we still don't really know how it works.

[Noah Ryan @NoahRyanCo]

Emasculation Nation w/ @AbudBakri
- The mechanisms behind testosterone
- Gene therapy + natty enhancements
- How to combat the low-T crisis

And much more. Watch it here:

[Abud Bakri MD @AbudBakri]

This was a fun one!

@hubermanlab and the @scicomm team are all stars. Understand why they are so astronomically successful

This could really serve as a table of contents for 50 hours more of discussions.

You’ll get the first taste of the thymus files, which I think is the most interesting avenue for peptides in the future