caflischgroup

Computational structural biology @uzh_ch
drug discovery, simulation & advanced sampling, analysis tools devpmt, amyloid research
Account managed by group member

[caflischgroup @caflischgroup]

✨🧬Thrilled to announce our latest study on #JMedChem:

A structure-based design of a powerful inhibitor targeting YTHDC1, a key m6A reader. Congrats to @z_frantisek and all the team! #DrugDiscovery

Discover more in the link below 👇👇👇

https://t.co/eFZpSVBBNn

[caflischgroup @caflischgroup]

🔬Unveiling the first CRBN-based PROTACs for the METTL3-14 m6A-RNA writer 🧬Opening new possibilities in epitranscriptomics research 🌐
Check out our most recent publication in JACS Au 👇@uzh @JACS_Au
https://t.co/hVwQXI5Htj

[caflischgroup @caflischgroup]

New story out: we reveal the first inhibitors of the m7G-RNA writer METTL1. @ACSBioMed

https://t.co/hzCqtK1Z4K

[caflischgroup @caflischgroup]

Check out this new work on the reevaluation of bromodomain ligands targeting BAZ2A 👇👇

@NevadoLab @GrazianoLolli @UZH_en @UniTrento

https://t.co/KVxFRiL02T

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Disrupting dimeric β-amyloid by electric fields

By Amedeo Caflisch et al @UZH_en @caflischgroup #Alzheimers

🔓 Open access in ACS Physical Chemistry Au 👉 https://t.co/HuinfeGzNu

[The Journal of Physical Chemistry @JPhysChem]

Disrupting dimeric β-amyloid by electric fields

By Amedeo Caflisch et al @UZH_en @caflischgroup #Alzheimers

🔓 Open access in ACS Physical Chemistry Au 👉 https://t.co/ik63WXE2EI

[caflischgroup @caflischgroup]

Please check out the UZH Award for Research in Brain Diseases that will be presented for the 18th time on Thursday, July 13, 2023.

All the information down here 👇:
https://t.co/bzVKvo7vzv
@UZH_en

[caflischgroup @caflischgroup]

Check our new work on Decrypting Integrins by Mixed-Solvent Molecular Dynamics Simulations @ioana_ilie_UvA @JCIM_JCTC

https://t.co/YGWRtvrMja

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Structure-based design of inhibitors of the m6A-RNA writer enzyme #METTL3

By Amedeo Caflisch et al @UZH_ch @caflischgroup 

🔓 Open access in ACS Bio & Med Chem Au 👉 https://t.co/lKe7dBky02

[caflischgroup @caflischgroup]

Which features of the spiking activity capture better the working memory processes of the human brain?
Check this out in our latest work !

https://t.co/NoUGGAhvaG

[caflischgroup @caflischgroup]

Huge congratulations and best wishes to Dr. Bedi!!!

[caflischgroup @caflischgroup]

Best of luck to Rajiv!! #PhD #phdlife

[caflischgroup @caflischgroup]

We have identified and characterized by x-ray crystallography the first small-molecule ligands of the m6A-reader YTHDF2. Two of them features good ligand efficiency, providing a starting point for hit optimization. @ACSMedChemLett @ACSPublications

https://t.co/6uiLMW4qHX

[Ioana M. Ilie - @biosim-lab.bsky.social @ioana_ilie_UvA]

Antibody binding makes the prion protein more flexible! #compchem #prions https://t.co/chjUtp3uPr @BBAjournals

[caflischgroup @caflischgroup]

Here, we investigate the influence of the POM1 and POM6 antibodies on the flexibility of the mouse prion protein (PrP) by molecular dynamics simulations. #prions #compchem @ioana_ilie_UvA @BBAjournals
https://t.co/0blji25BCp

[caflischgroup @caflischgroup]

Molecular dynamics simulations at different temperatures suggest structural reasons for the distinct behavior of two microbial transglutaminases. @clangi3 @amedeocaflisch @CSB_Journal
https://t.co/BixfjF8k69

[caflischgroup @caflischgroup]

Little is known about the potential interactions between flexible tail, globular domain, and the membrane. Here, we used atomistic simulations to investigate how these interactions are modulated. @BiophysJ @ioana_ilie_UvA @MarcoBacci07 @amedeocaflisch
https://t.co/h3qlfGPwWe

[caflischgroup @caflischgroup]

We used in-silico methods to design binders for the m6A reader protein YTHDC1, leading to highly efficient lead compound and thus pushing the field to the forefront.
@ELSchemistry @amedeocaflisch

https://t.co/maX5BdgaXq

[caflischgroup @caflischgroup]

Domino effect in allosteric signaling of peptide binding: We apply a novel method to analyse complex MD data and elucidate allosteric pathways without previous knowledge of the system. Check @JMolBiol for more. @pavaro2906 @amedeocaflisch
https://t.co/LM64Ana0iu

[caflischgroup @caflischgroup]

The best hat for the best hat maker! Best wishes and congratulations to Ilaria!! #PhDone

[caflischgroup @caflischgroup]

Best of luck to Ilaria!! #PhD #phdlife