Computational structural biology @uzh_ch
drug discovery, simulation & advanced sampling, analysis tools devpmt, amyloid research
Account managed by group member
✨🧬Thrilled to announce our latest study on #JMedChem:
A structure-based design of a powerful inhibitor targeting YTHDC1, a key m6A reader. Congrats to @z_frantisek and all the team! #DrugDiscovery
Discover more in the link below 👇👇👇
https://t.co/eFZpSVBBNn
🔬Unveiling the first CRBN-based PROTACs for the METTL3-14 m6A-RNA writer 🧬Opening new possibilities in epitranscriptomics research 🌐
Check out our most recent publication in JACS Au 👇@uzh @JACS_Au
https://t.co/hVwQXI5Htj
Disrupting dimeric β-amyloid by electric fields
By Amedeo Caflisch et al @UZH_en@caflischgroup#Alzheimers
🔓 Open access in ACS Physical Chemistry Au 👉 https://t.co/HuinfeGzNu
Disrupting dimeric β-amyloid by electric fields
By Amedeo Caflisch et al @UZH_en@caflischgroup#Alzheimers
🔓 Open access in ACS Physical Chemistry Au 👉 https://t.co/ik63WXE2EI
Please check out the UZH Award for Research in Brain Diseases that will be presented for the 18th time on Thursday, July 13, 2023.
All the information down here 👇:
https://t.co/bzVKvo7vzv
@UZH_en
Structure-based design of inhibitors of the m6A-RNA writer enzyme #METTL3
By Amedeo Caflisch et al @UZH_ch@caflischgroup
🔓 Open access in ACS Bio & Med Chem Au 👉 https://t.co/lKe7dBky02
Which features of the spiking activity capture better the working memory processes of the human brain?
Check this out in our latest work !
https://t.co/NoUGGAhvaG
We have identified and characterized by x-ray crystallography the first small-molecule ligands of the m6A-reader YTHDF2. Two of them features good ligand efficiency, providing a starting point for hit optimization. @ACSMedChemLett@ACSPublications
https://t.co/6uiLMW4qHX
Here, we investigate the influence of the POM1 and POM6 antibodies on the flexibility of the mouse prion protein (PrP) by molecular dynamics simulations. #prions#compchem@ioana_ilie_UvA @BBAjournals
https://t.co/0blji25BCp
Molecular dynamics simulations at different temperatures suggest structural reasons for the distinct behavior of two microbial transglutaminases. @clangi3@amedeocaflisch@CSB_Journal
https://t.co/BixfjF8k69
Little is known about the potential interactions between flexible tail, globular domain, and the membrane. Here, we used atomistic simulations to investigate how these interactions are modulated. @BiophysJ@ioana_ilie_UvA@MarcoBacci07@amedeocaflisch
https://t.co/h3qlfGPwWe
We used in-silico methods to design binders for the m6A reader protein YTHDC1, leading to highly efficient lead compound and thus pushing the field to the forefront.
@ELSchemistry @amedeocaflisch
https://t.co/maX5BdgaXq
Domino effect in allosteric signaling of peptide binding: We apply a novel method to analyse complex MD data and elucidate allosteric pathways without previous knowledge of the system. Check @JMolBiol for more. @pavaro2906@amedeocaflisch
https://t.co/LM64Ana0iu