@roxboxfix If the studies included in the meta-analysis predominantly favor combination therapy,the pooled results would be expected to favor the combination therapy as well.
@hongjaechon@JHEP_Reports@StephenLChan1@changhoon_yoo The number of patients with MVI is limited, and its adverse prognostic significance is already well established. However, these findings do not identify a preferred therapeutic strategy for this subgroup.
@hongjaechon@JournalofNucMed Currently, patient selection for GPC3-targeted therapies (like ADCs, CAR-T, or antibodies) mainly relies on tissue IHC, but tissue acquisition can be difficult and fails to heterogeneity. Could immuno-PET become a standard tool for non-invasive stratification in the future?
@tompowles1@DrChoueiri Since the FDA has approved Merck's WELIREG® (belzutifan) for treating patients with advanced renal cell carcinoma (RCC) following prior treatment with a PD-1 or PD-L1 inhibitor and a VEGF-TKI, why is cabozantinib still used as the control arm in ph3 trial?