Cassie Mitchell

PhD, RDN • Obesity, nutrition and metabolism • Researcher at OU Health Sciences Center• #anishnaabe • I enjoy science, nature and dogs • Opinions are my own.

[Cassie Mitchell @cassiemmitchell]

Thank you so much to my mentors, @NIH_LRP, and @NIDDKgov for supporting and believing in me as an Indigenous, first-gen college student! This award is absolutely life changing!

[Cassie Mitchell @cassiemmitchell]

@TamarHaspel @_captainscience Thanks for your questions! Crossing my fingers for a smooth submission later this week. 🤞🏽

[Cassie Mitchell @cassiemmitchell]

@TamarHaspel @_captainscience Yes, for some individuals kcals were increased or decreased to keep weight stable. overall this suggests there might be a regulatory effect on metabolism, esp given how EE was measured... but our sample was relatively small and male only, so it’s not without limiters.

[Cassie Mitchell @cassiemmitchell]

@TamarHaspel @_captainscience (2/2) When kcals are adjusted to maintain body weight, often it’s by 200 or less depending on the degree of body weight fluctuation.

[Cassie Mitchell @cassiemmitchell]

@TamarHaspel @_captainscience (1/2) Good question, and IMO that’s what makes the results interesting. When participants are fed a weight maintaining diet, their kcal intake is adjusted prn to keep their body weight stable. This is a common practice in studies where researchers want to control for body weight.

[Cassie Mitchell @cassiemmitchell]

@angryhacademic @TamarHaspel @OnlyInMen No worries! While I didn’t design the study (postdoc), I do know that the FDA guidance on fish and pregnancy were used when this study was designed several years back and that the plan is to include women in a follow-up to this.

[Cassie Mitchell @cassiemmitchell]

@_captainscience @TamarHaspel (2/2) We have several follow-ups (sample processing, data analyses and study protocol) in progress- will be interesting to see whether or not they provide any clarity on this data. For now we remain curious and cautious.

[Cassie Mitchell @cassiemmitchell]

@_captainscience @TamarHaspel (1/2) Manuscript will be submitted soon. But all participants (as noted on poster) were fed weight-maintaining diets. Full EE, Glucose data, body weight and comp, and remaining variables will be presented in manuscript and tables.

[Cassie Mitchell @cassiemmitchell]

@angryhacademic @TamarHaspel @OnlyInMen Hi there, these are secondary aims from the following trial. Rationale for male population is detailed here. 👍🏽https://t.co/bzmnK0V0vy

[Cassie Mitchell @cassiemmitchell]

@Haub_KSU @BioLayne Thanks! We have several follow-ups (sample processing, data analyses and study protocols) in progress- will be interesting to see whether or not they provide any clarity on this data. For now we remain curious and cautious.

[Cassie Mitchell @cassiemmitchell]

@Haub_KSU @BioLayne (2/2) Body comp (measured by DXA), and body weight will be in the main text and figures of the manuscript along with glucose data. As with ALL data, skepticism is essential and results need to be replicated in larger studies.

[Cassie Mitchell @cassiemmitchell]

@Haub_KSU @BioLayne (1/2) As I stated on the original thread- We’re in process of submitting for publication. FBG is included as a figure on the poster, but space was limited for the abstract text.

[Cassie Mitchell @cassiemmitchell]

@TheAlanAragon @TheBhupiThakur @davidludwigmd @The_Nutrivore @BioLayne @rebelhealth1 Agreed. I have had similar questions about clinical significance, esp as a dietitian. Will be interesting to see whether or not the planned f/u studies and sample analyses find anything similar.

[Cassie Mitchell @cassiemmitchell]

@TheBhupiThakur @TheAlanAragon @davidludwigmd @The_Nutrivore @BioLayne @rebelhealth1 We’re in process of submitting for publication. Body comp was measured using DXA, noted in the experimental design figure w/ bullet point of outcome in results. As with ALL data, skepticism is essential and results need to be replicated. 👍🏽