Castello Lab

RNA-binding proteins in virus infection

[Castello Lab @castello_lab]

🎉 Congrats to Namah Raut for winning the Journal of General Virology Talk Prize at the Microbiology Society PGVN Meeting! Her talk revealed how Zika virus riboregulates p62 to modulate autophagy—shedding light on viral-host interplay. 👏🦠 #Virology #PGVN2025 #ZikaVirus

[Castello Lab @castello_lab]

Checkout our new paper on Biorxiv by @LouieIselin : Type I interferon doesn’t just turn on the expression of interferon stimulated genes, it globally remodels the RNA-bound proteome. In collaboration with @ShabazLab https://t.co/Ljohzk6gPd

[Castello Lab @castello_lab]

Amid the challenges of a global pandemic, Natasha joined @Castellolab and embarked on an extraordinary journey. We proudly celebrate successful defence of her thesis. Her dedication and skills provide new insights into #tRNA ligase complex in health & infection. Congrats Natasha!

[Alfredo Castello @Alf_Castello]

Excellent talk of Louisa Iselin in the "Expanding world of RBPs" conference at #embl Heidelberg on the RBPome remodelling induced by interferon. #RBP, #RNA, #interferon

[Castello Lab @castello_lab]

We are very proud of our new preprint revealing #alphaviruses induces cellular #RNA #degradation via XRN1 and the decapping complex to feed viral #replication with nucleotides. Thanks to the whole team and collaborators for the fantastic work.

https://t.co/b0PgcMcq0D

[Castello Lab @castello_lab]

🚨 Huge congrats to our rising star @WaelSKamel, rest of @castello_lab and collaborators! @MolecularCell, U2 snRNP moonlights as an #antiviral complex interacting with viral #RNA through the U2 snRNA. Is this a new example of RNA-guided antiviral activity analogous to #RNAi? 🦠👏

[Molecular Cell @MolecularCell]

Online Now: Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles https://t.co/BevNuk7cN2

[Castello Lab @castello_lab]

Our lab group is thrilled to have won with our "Do-Re-Mi" costume from The Sound of Music for the "music" themed Christmas party!
It was a fantastic team effort and a great way to bond. Thanks to everyone who voted for us! Happy holidays from our lab to yours!

[Alfredo Castello @Alf_Castello]

Really important achievement.. Price to the most original lab costume for the @castello_lab in the @CVRinfo Christmas party. Inspired by the notes of the "Sound of Music"😁. 🍾🥂🏆

[Castello Lab @castello_lab]

Delighted to share Inner Jarmson successfully defended his PhD thesis on identification of #RNA editing #enzymes involved in #virus infection. He did an amazing job defending his work in viva. Congratulations to Innes for his dedication and hard work! We are very proud of you!

[Eduardo A. Sagredo @esagredo]

It was amazing to share and listen to @Alf_Castello at the @scilifelab Spotlight seminar series yesterday. Very inspiring, engaging and cool science done by him and his team @castello_lab.
Hope to see you soon and thanks for sharing with us in Sweden 🇸🇪 @pelechanolab.

[Castello Lab @castello_lab]

Attention UK students! The James McCune Smith PhD Scholarships at the @UofGlasgow offer opportunities for underrepresented black students in the UK. Benefits include mentorship, leadership training, and 6-month placements. If you are interested in applying contact us!

[Castello Lab @castello_lab]

We are delighted to share one of our exceptional MSc student has been awarded with MSc in Infection Biology Best MSc Project Award (2023/2024) for her research, “Towards Elucidating the Complexes Formed by SARS-CoV-2 Proteins.”
#SARSCoV2 #RNAbiology #InfectionBiology

[Molecular Cell @MolecularCell]

Large-scale map of RNA-binding protein interactomes across the mRNA life cycle https://t.co/SZY7UtoBrE

[Alfredo Castello @Alf_Castello]

Proud of our contribution to the Focus on RNA Biology issue in @MolecularCell. We discuss the new approaches to uncover the viral RNA interactome and recent important discoveries derived from them.

[Castello Lab @castello_lab]

@JamesLPurr @MolecularCell “A virus is bad news wrapped in protein,” said Sir Peter Medawar. While much research has explored the interactions of viral proteins, we still still have a very fragmentary understanding of the cellular factors that engage with the viral RNA—the “bad news” itself.

[Castello Lab @castello_lab]

@RobKlose Congratulations @RobKlose and team!!!

[Castello Lab @castello_lab]

Proud of our recent work uncovering the RNA binding mechanism of TRIM25. We combine biophysics with molecular and cellular biology to map the amino acids in TRIM25 involved in the interaction with RNA and show that they are critical for its antiviral role. #RNA, #virus

[Lucía Álvarez @LuciaChemist]

We are excited to share our latest research, a joint effort between the Hennig group at @EMBLHeidelberg and the @castello_lab at @CVRinfo . We’ve uncovered the key residues for the RNA binding of TRIM25, which plays a key role in its antiviral activity. 🔗 https://t.co/uMrHghH2Xo

[Castello Lab @castello_lab]

Very proud of our contribution to the @MolecularCell issue with "Focus on RNA biology". Our review focuses on the interactions that viral RNA establishes with the host cell and the emergence of new approaches to profile them systematically. #virus, #RNA

[Alfredo Castello @Alf_Castello]

1/4 🧬 In this study, we delve into innovative methods to explore the viral RNA interactome. Our approach allows for step-dependent analysis of viral infection and provides resolution at the level of specific viral RNA species.

[Castello Lab @castello_lab]

Saying the hardest goodbye to an amazing postdoc of our lab Azman Embarc. His dedication, hard work, and positive spirit has made a lasting impact on all of us. Wishing you all the best in your future endeavours! You’ll be missed!

[Alfredo Castello @Alf_Castello]

We bid a fond farewell to Azman Embarc, our brilliant postdoc researcher, as he embarks on a new journey. Your contributions to the @castello_lab have been invaluable, and you will be greatly missed wishing you the best in your future endeavours, Azman!!! 🍻🎉🎉

[Castello Lab @castello_lab]

Excited to share our latest bioRxiv paper, in collaboration with @FranklinSystems (@RosFrankInst ), which explores virus permissive, intermediate, and hostile intracellular environments using multiple Omic platforms. Grateful for the amazing teamwork! https://t.co/eWlyr3zgcc