Hermansky-Pudlak syndrome causes Crohn’s disease-like inflammation, lung fibrosis, and macrophage lipid accumulation. Here researchers show dysregulated immunometabolism contributes to the impaired anti-microbial immunity and inflammation:
https://t.co/aqlsy53PAd
Thrilled to share our research article on the cellular underpinnings of inflammation in Hermansky-Pudlak syndrome type 1. Thank you to all our wonderful collaborators! @NDMOxford@OxImmuno@sumeetpandey88@DominikAschenb2@HPSNetwork
https://t.co/3CtyEujbF8
Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: https://t.co/vtBGmTkKhy 1/
4 years + 1 pandemic = #PhDone. Much to come on #adipocyte#autophagy. Looking forward to the next step. Thank you the entire @aksimonlab and my friends and family for supporting me though this journey. Very happy right now. :)
We found that cells detect #SARSCoV2 infection through the #RNA sensor MDA5, to elicit a type I & III #IFN response. However, release of other pro inflammatory #cytokines like #TNF is MDA5-independent. You can read our collaborative #OpenSource work here: https://t.co/3QyUfjREUW
Our work quantifying the discriminatory power of T cells is now published in @eLife with a great press release:
Immune cells imperfect at distinguishing between friend and foe, study suggests https://t.co/b1XwIvqY3j
Proud of my superstar partner, Johannes, who passed his viva with flying colors yesterday and whose paper is out today in @eLife! A great collaboration of the @Dushek and @TeaCellBiology labs showing that the discriminatory power of T cells is imperfect
https://t.co/avCfYaiu4p
Today our COMBAT Consortium paper looking at the immunological hallmarks of COVID-19 is out on medRxiv https://t.co/ukhIOYxuCL @OxfordMedSci@NDMOxford@RDMOxford
Huge congratulations to @DominikAschenb2 and Melania from the lab! Incredible to see this work out, borne out of a large, multi-national collaboration to describe GoF SYK variants.
🚨ONLINE NOW @NatureGenet by Aleixo M. Muise and colleagues:
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
➡️https://t.co/Q1aMVRZBFX
Time to start spreading the word and sharing! Here is the link to our HPS Awareness Day donation page: https://t.co/5yIWBfhL78. You can text, email, and share on social media! There’s still time to create a personal page, go to https://t.co/k4IDAzBpD6 for info!