Paediatrician and Research fellow interested in gastrointestinal immunology and epithelial cell biology. Trained @ChariteBerlin. @NDMOxford. Uhlig Lab.
Happy to share our review summarising new monogenic IBD genes and highlighting how functional understanding of genetic defects paves the way for personalised medicine. https://t.co/zPnH6a0D8h
Excited to share our latest human multipatch paper, now out in @NatureNeuro : https://t.co/xwnzMzftqH
We studied the cellular and synaptic physiology of L2–3 pyramidal neurons from the human cortex and identified subtype-specific connectivity rules.
🧠 Curious about how neurons are wired in the human cortex?
Our @ScienceMagazine study tested over 7,000 connections and revealed key differences from rodents:
"Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit". 🧵👇https://t.co/yUeQjbDSh7
Check out new pre-print 👇
A longitudinal scRNAseq therapeutic atlas of anti-TNF in IBD https://t.co/ChbYGbkMCv
Super fun collab with dream team @arthritisbham, Holm Uhlig, Simon Travis & the outstanding clinical fellow and DPhil student @TomThom03928021! 💫
Human TLR4 deficiency Capitani et al. https://t.co/1AM6B6FMJT
accompanied by Li et al describing Human MD2 deficiency https://t.co/yURnr1OoWL
Congratulations to Daniel Kotlarz, Christoph Klein and VEOIBD collaborators.
Hermansky-Pudlak syndrome causes Crohn’s disease-like inflammation, lung fibrosis, and macrophage lipid accumulation. Here researchers show dysregulated immunometabolism contributes to the impaired anti-microbial immunity and inflammation:
https://t.co/aqlsy53PAd
Happy to share our review summarising new monogenic IBD genes and highlighting how functional understanding of genetic defects paves the way for personalised medicine. https://t.co/zPnH6a0D8h
1/ In @JExpMed, @tutu_ZQ, Daniela Matuozzo, @Jeremie_LP, @RiceLaboratory, @ShenYingZhang1, @AurelieCobat, report recessive inborn errors of type I IFN immunity in 12 of 112 children (10.7%) who were hospitalized for COVID-19 pneumonia (https://t.co/4Xzp1gU2QW).
Want to use modern neuroscience to understand Parkinson’s Disease and DBS, but not familiar yet with the available tools?
Check out our new review highlighting different ephys and optical approaches and how they have pushed the rodent PD/DBS field forward. https://t.co/cV4BwDole3
#monogenicIBD science!
2 papers in @SciImmunology - @MonicaYabal and Sebastian Zeissig - XIAP and IBD - Paneth Cells
Editorial by Uhlig @a_azabdaftari
Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency https://t.co/NxUbSEBchW
Exciting work by @damwahida/@MonicaYabal & ZeissigLab highlights the power of monogenic IBD to understand the link between epithelial dysfunction, the microbiome🦠, and intestinal inflammation🔥.
Delighted to contribute a Focus article in @SciImmunology🤩: https://t.co/81FQPKhNMy