Ceron Lab

Using the nematode C. elegans to investigate human diseases and enjoy science.
Tweets all come from Julián Cerón, PI of the group.
Also🎙 in @raticosde100cia

[Ceron Lab @CeronLab]

🎉 Happy to share this review on such a relevant topic.
🤗Thanks to @JHmeljak for being a great and very helpful editor and @dmm_journal @Co_Biologists for their fantastic editorial process.

🧵👇🏼

Caenorhabditis elegans for research on cancer hallmarks https://t.co/PTeBT4uyRE

[Ceron Lab @CeronLab]

Meritocracia 🙏

[EL MUNDO @elmundoes]

Pablo Jarillo-Herrero, físico del MIT y Premio Fronteras del Conocimiento en Ciencias Básicas de la Fundación BBVA, explica cómo España puede atraer talento internacional

📹 Alberto Di Lolli

[Ceron Lab @CeronLab]

This work is the result of a grant from @PpccSalud with the fantastic collaboration of teams led by @nstroustrup1 at @CRGenomica, Rafael Pulido at @biocrucesHRI, @Olmedo_lab at @unisevilla, Victor J. Cid at @unicomplutense and @MfPez at @IBMB_CSIC

@gusaneros1

[Ceron Lab @CeronLab]

🔥New Preprint from our lab @idibell_cat @IBV_CSIC

📢In vivo functional classification of PTEN variants reveals context-dependent oncogenicity and interindividual variability

https://t.co/SYwwtJBtca

[Ceron Lab @CeronLab]

(3/4) 🪢 The functional impact of secondary mutations on PTEN variant outcomes

(4/4) 👩 🧔‍♂️ 👱‍♀️ 🧑‍🦰 Inter-individual variability among isogenic animals with identical mutational landscapes, studied using single-worm RNA-seq

[Rafa Vázquez #SinCienciaNoHayFuturo @monkeyplatillos]

Nice overview of one of the most amazing animals on Earth!
@gusaneros1 @annajuanroch @AMV_REDOX @raticosde100cia @IISLaFe
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism | PNAS https://t.co/yXktE8pPmv

[Rafa Vázquez #SinCienciaNoHayFuturo @monkeyplatillos]

Time to get ready for the Spanish Worm Meeting!!

https://t.co/FgBem9khWk

[IBV-CSIC @IBV_CSIC]

El pasado lunes recibimos a Gary Ruvkun, Premio Nobel de Medicina 2024, invitado por @PremiosReiJaume en el @IBV_CSIC

Conoció a personal, IPs y estudiantes, compartiendo experiencias y consejos científicos.

¡Gracias a todos los participantes! 💙

#IBVCSIC #Ciencia #Nobel

[Rafa Vázquez #SinCienciaNoHayFuturo @monkeyplatillos]

We are geting closer to the deadline!!
https://t.co/FgBem9khWk
Register yourself, guys! Worms are one of the coolest creatures on Earth

@ehuntingtones @AsociacionAVAEH @FEDER_ONG @LluisMontoliu

[Rafa Vázquez #SinCienciaNoHayFuturo @monkeyplatillos]

Come on guys and girls! We're getting closer to the deadline for the one and only, awesome, incredible, and amazing X Spanish Worm Meeting in the lovely city of Valencia!
https://t.co/FgBem9khWk

[Ceron Lab @CeronLab]

Pues así sigue el asunto. Proyecto de tecnologías #CRISPR parado 4 meses porque van muy liados. Esta es la triste realidad @DianaMorantR . La burocracia son plomos atados al cuerpo que nos dificultan mucho producir y competir, aunque sea con mucho menos presupuesto.
Agotador 🥵

[Ceron Lab @CeronLab]

Solicitado a principio de Febrero a la @AgEInves el cambio de los fondos de un proyecto del @CienciaGob de un centro a otro por mudanza del laboratorio, y aún estamos esperando contestación.
4 meses con el proyecto parado por una burocracia y administración que no se entiende.

[WIMI Biotech @wimi_biotech]

🧬 Compact CRISPR nucleases are small — but often slow to activate. A new strategy just fixed that.

New preprint from Liu Junjie lab (Tsinghua): fusing ATPase DnaA to PlmCas12e (CasX) via a rigid N-terminal linker overcomes the conformational activation barrier.

⚡ 1.34× average editing boost across 7 endogenous loci in HEK293T
📈 More effective genome targets detected by GenomePAM/GUIDE-seq
🔬 MD simulation: single free-energy basin vs. rugged landscape in WT
❌ ATP hydrolysis mutant: activity drops below wild-type — mechanism confirmed

Liu lab, Tsinghua | Preprint
https://t.co/zt4qkt9roo

#CRISPR #Cas12e #CasX #ProteinEngineering #GeneEditing

[IBV-CSIC @IBV_CSIC]

📢 ¡𝗢𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝗱𝗮𝗱 𝗽𝗿𝗼𝗳𝗲𝘀𝗶𝗼𝗻𝗮𝗹 𝗲𝗻 𝗜𝗕𝗩-𝗖𝗦𝗜𝗖!

Vacante para Investigador Distinguido en inmunología, identidad celular y biología computacional con IA.

🔒Posición permanente y start-up package.

👉Más Info en: https://t.co/SMTnteGzIt

#ibvcsic

[WIMI Biotech @wimi_biotech]

🧬 CRISPR evolution — directly inside human cells — for the first time.

PNAS: CRISPR-MACE uses adenovirus replication to continuously mutate, select, and amplify Cas9 variants in human cells, bypassing bacterial evolution limitations.

Key results:
🔑 "Gatekeeper" G12D mutation: 3× higher DNA affinity
💪 DVKIH 5-mutant variant: ~1000× anti-CRISPR resistance
✅ Validated in CASFISH imaging — brighter, stronger signal

Shoulders & Choudhary labs, Broad Institute | PNAS
https://t.co/xiDN12zbBv

#CRISPR #DirectedEvolution #Cas9 #GeneTherapy #Broadinstitute

[Antonio Miranda Vizuete @AMV_REDOX]

@CeronLab @AgEInves @CienciaGob La burocracia es una lacra en todos los aspectos. Pero en el campo de la ciencia, va a acabar con ella...

[Cost Action GenE-Humdi @GeneHumdi]

The round table featuring all speakers and moderated by Francisco Martin and Marcello Maresca was a great brochure for the session on the novel Gene Editing Tools. @GeneHumdi #Granada2026 #AnnualMeeting @genyo_pts

[Cost Action GenE-Humdi @GeneHumdi]

We are back at @GeneHumdi #Granada2026 #AnnualMeeting with a session focussed on new tools for the advancement of #GenomeEditing at @genyo_pts with support of @FProgresoysalud

[F. Javier Molina E. @tweet_Javi]

@GeneHumdi @CeronLab Closing the session, two short talks: First Araceli Aguilar @genyo_pts presents "A novel dual-guide CRISPR–Cas13 strategy for enhanced SNV detection" with clear implications to improve diagnostic use of CRISPR tools.

[Cost Action GenE-Humdi @GeneHumdi]

We are opening with Julian Cerón @CeronLab presenting how old Deep Ocean organisms can surface novel discories to help #GenomeEditing