Carlos Ronchi

Mathematician. Computational Biologist. Newsletter:

[Frank Harrell @f2harrell]

New blog article challenging medical researchers who are drawn to clustering patients to create so-called "phenotypes" to think again: https://t.co/50fqPRSLLl @MaartenvSmeden @statsepi0 #Statistics #PrecisionMedicine @vandy_biostat

[Carlos Ronchi @chronchi]

@HazelQuinn24 Thank you so much Hazel!

[Carlos Ronchi @chronchi]

@Ana_Samarkina Thanks 🥳

[Carlos Ronchi @chronchi]

I defended my PhD thesis at EPFL! Thank you everyone that joined and contributed in every aspect of my PhD. I'm looking forward to what comes next in Chicago!

[CANCERPREV @CANCERPREV1]

Hearty congratulations, @chronchi on outstanding and engaging public thesis defense! Best of luck, and we look forward to seeing all the amazing things you will accomplish! @epflSV @nature_npj Learn more about EMBER: https://t.co/oaEzrRWaEC

[Carlos Ronchi @chronchi]

@Jovan_Isma Thank you!

[Carlos Ronchi @chronchi]

@MarcosTreviso Valeu Marcão!

[George Sflomos @sflomos]

Phenomenal work, tumor agnostic pipeline for oncology and precision medicine! ⬇️⬇️⬇️⬇️⬇️
@chronchi 's baby called #EMBER provides a calibration and reference tool that paves the way for using #RNAseq as a standard diagnostic and predictive tool for #ERpos breast cancer @CBrisken @epflSV #TCGA #METABRIC #SCANB #estrogen receptor signaling, cell #proliferation,
#DNA repair, and #epithelial-mesenchymal #transition

[Carlos Ronchi @chronchi]

@sflomos Definitely it's something that could be done, as ERBB2 and other genes on the HER2 amplicon region are in the list of >8000 genes for pathway analysis!

[Carlos Ronchi @chronchi]

I’m very happy to announce that our manuscript has been published at npj breast cancer, together with @CBrisken and Syed Haider!
We propose a new algorithm to do single sample integration into a common reference space. (1/n) https://t.co/YYUhR0GkPY

[Carlos Ronchi @chronchi]

The analysis can be found online too (https://t.co/hwpg3GRNy9) with all the figures and a chapter specific for the analysis done during the revision process. (6/6)

[Carlos Ronchi @chronchi]

It was very important for us to make the study as reproducible as possible. I created a docker image in which everyone should be able to reproduce all the figures from the paper (https://t.co/oEbyjfHXfw). (5/n)

[Erik van Zwet @ErikVanZwet]

Don't like p-values? We're presenting a completely new interpretation in the context of clinical trials. With Andrew Gelman, Sander Greenland, @guido_imbens Simon Schwab and Steve Goodman. @Lester_Domes @goodmanmetrics @NEJMEvidence
https://t.co/iIu46aY3mZ

[Max Kuhn @topepos]

Fantastic talk by @jcheng at #positconf2023 on using #shiny with #quartopub.

I've made an #rstats Quarto book demo with a wasm-embedded shiny app to demonstrate how class boundaries change with the complexity of natural splines.

Sources: https://t.co/xMvr2uCID7

[Priscila Cavassin @CavassinP]

It's amazing to see our work so beautifully represented, thank you @sciencebrush!

[Lior Pachter @lpachter]

In new work, @LambdaMoses et al. introduce the Voyager platform for spatial and non-spatial 'omics analysis:
🚴‍♀️ Builds on the geospatial statistics tradition
🚴‍♀️ Addresses discordance between Seurat & Scanpy
🚴‍♀️ Engineered in R (@Bioconductor) & Python
https://t.co/LR9hZdNRxK 1/🧵

[Cancers MDPI @Cancers_MDPI]

🔊Scientists can now utilize an optimized preclinical model for lobular breast carcinoma, which accurately reflects the different cancer stages. This tool can help advance lobular breast research @epflSV @sflomos @CBrisken @brisken @MHH_life👏
📌Link here: https://t.co/XlNApeFutd

[Carlos Ronchi @chronchi]

Had a great time in Gent, both presenting and learning from the other ESRs and PIs!