Dmitriy M Chudakov

Our small green planet

[Mikhail Shugay @antigenomics]

N.B. VDJdb is up and running after a planned server upgrade, it can be now accessed at https://t.co/nN8YpIHvn7, the old https://t.co/BLnLDknlTs URL redirects there and should be considered obsolete. If you are using VDJdb web API please update accordingly.

[Dmitriy M Chudakov @ChudakovM]

@MaxKonigMD @jhrheumatology @cmm Glad to see )

[Dmitriy M Chudakov @ChudakovM]

@pogorely @StJudeResearch Mikhail, my congrats and respect.

[Mikhail Pogorelyy @pogorely]

First manuscript from my group! 🐢🐢🐢🐢 @StJudeResearch

[Dmitriy M Chudakov @ChudakovM]

Structure-based prediction of T cell receptor recognition of unseen epitopes using TCRen. Yes, it works: https://t.co/A2XJe9Erbt

[Dmitriy M Chudakov @ChudakovM]

And one more manuscript from our team, also focussed on Treg. Purely repertoire-based as we like)) Beautiful (!) data from Prof. Rudensky. Long work, short read. https://t.co/nvwWMqsQHH

[Dmitriy M Chudakov @ChudakovM]

Happy to report our development for scRNA-Seq analysis. Employs splicing information at the level of clustering and dimensionality reduction. Readily revealed beautiful aspects of Treg and Th1/CD4+ cytotoxic biology. Try! https://t.co/J9SmdmwKuN

[Dmitriy M Chudakov @ChudakovM]

@ButtersSlim 3rd phase approved, starts next year. From now, ~3 years to the wide market. Maybe earlier, if they give eraly registartion. How wide it will go in the current world - do not know. I'm only immunologist. But guess many companies will go this direction, we just opened the gates ))

[Dmitriy M Chudakov @ChudakovM]

We started this work ~15 years ago. Now it is on the 2nd phase clinical trial. With all the circumstances, things evolve towards new generation immunotherapies, to make life happier on our small fragile planet.

[Nature Medicine @NatureMedicine]

Targeted depletion of TRBV9+ T cells induces remission in a single ankylosing spondylitis patient, with significant improvements in functional and mobility metrics #Immunotherapy #AnkylosingSpondylitis https://t.co/KXc0EL7nHv

[Nature Medicine @NatureMedicine]

Targeted depletion of TRBV9+ T cells induces remission in a single ankylosing spondylitis patient, with significant improvements in functional and mobility metrics #Immunotherapy #AnkylosingSpondylitis https://t.co/KXc0EL7nHv

[Dmitriy M Chudakov @ChudakovM]

@NatureMedicine We started this work ~15 years ago altogther. Now it is in 2nd phase clinical trial. With all the curcumstances, the things evolve towards better immunotherapies, to make the life happier on our small fragile planet.

[Dmitriy M Chudakov @ChudakovM]

https://t.co/L2AV7jYkgW

[Dmitriy M Chudakov @ChudakovM]

https://t.co/wM9jxRTpX5

[Pavel Tomancak @PavelTomancak]

Spectacular finding from Dmitryi Chudakov group (time to get a Twitter handle!) @CEITEC_Brno. Blind moles are special, they #live #long and prosper, now we know, at least in part, why. It goes down to the organisation of their adaptive #immune #system. 👏

[Dmitriy M Chudakov @ChudakovM]

Great Misha's work

[Anastasia (Asya) Minervina @Asya_Minervina]

Our collaborative project (@pogorely, @elisarosix, @BensoudaMeriem, @an_franke, @ChudakovM and others) about longitudinal #TCR repertoire sequencing after #SARSCoV2 infection is now also on biorxiv. https://t.co/LtcOmFJPth

[Dmitriy M Chudakov @ChudakovM]

https://t.co/qwRbiiyhm5

Admiration, envy, hope, inspiration ... altogether. And love for Andrew Sewell and his way of thinking. Ultimately - inspiration.

[Dmitriy M Chudakov @ChudakovM]

https://t.co/XaV37HvsCq

Yet many things unclear, but was a great pleasure to dig.

SupplTable1 tries to summarize clinically relevant things, some controverisal. Great work by George Sharonov.

Intersting what people say on IgG1/IgG3 difference hypothesized on Fig. 3.

[Mikhail Shugay @antigenomics]

TCGA RNA-Seq analysis reveals strong association between Tumor-infiltrating B-cell antibody isotypes and survival in lung adenocarcinoma carrying specific driver mutations.
https://t.co/OwWCnPZbxq

[Dmitriy M Chudakov @ChudakovM]

Comprehensive analysis of antiviral adaptive immunity formation and reactivation down to single-cell level https://t.co/I9nZb1AikE

[Kedzierska Lab @kedzierskalab]

Our latest study on immune responses to the flu vaccine and B cell memory in human tissues is out today and featured on the cover of @ScienceTM!
@TheDohertyInst @UniMelbMDHS https://t.co/EnzG1u34rY