Clayton Bingham, PhD

Computational Neuroscientist | Data Scientist | Program Director | @NIH | Tweets are my own

[NINDS @NIH_NINDS]

Workshop opportunity! Interested in using neural stimulation & brain recordings to understand brain function? Register for this #BRAINInitiative 2-day virtual workshop, exploring progress made, challenges to overcome, & potential impact. #studyBRAIN https://t.co/yIlCkUc8Qx

[Clayton Bingham, PhD @claytonsbingham]

Reduced Thalamic Excitation to Motor Cortical Pyramidal Tract Neurons in a Mouse Model of Parkinsonism

“reduced motor cortical outputs in PD are an immediate consequence of basal ganglia inhibition but also involves local circuitry adaptations within M1”

https://t.co/6aRT7iMQm3

[Clayton Bingham, PhD @claytonsbingham]

Bad title, good article. At the end of the day, one problem is easier than three & small topics are easier than large.

Reality: Too many “day one” trainees think they should shake up a group with a flurry of new ideas. Unlikely as it is unproductive. https://t.co/020msz5g7A

[Clayton Bingham, PhD @claytonsbingham]

@iProgress_CC @RichCompNeuro @OpenAcademics @AcademicChatter …I forgot how hard it is to have protected time in the office. As much as I love spontaneous science chats and camaraderie, oof, it’s easier to buckle down and finish stuff away from the door knocks and shoulder taps.

[Clayton Bingham, PhD @claytonsbingham]

@AcademicChatter Don’t trust those who tell you “PhD isn’t a race”

[Clayton Bingham, PhD @claytonsbingham]

@LisaRGibson @Melterialsgal If it were, would it be such a bad thing?

[Clayton Bingham, PhD @claytonsbingham]

@bradpwyble @yael_niv @ashleyruba Not acknowledging the toxicity of, “still I don't charge them tuition”, is concerning

Do you have industry exp in a “typical” job? (none in CV)

I have & I disagree that PI job difficulty or investment in employees is greater than for major Corp managers

Let’s stop here 🫠

[Clayton Bingham, PhD @claytonsbingham]

@UnreadableP @yael_niv @ashleyruba The market doesn’t (strongly) determine postdoc salary and postdocs are actually difficult to recruit

https://t.co/ieNcWoJqx2

[Clayton Bingham, PhD @claytonsbingham]

@yael_niv @ashleyruba The implication then…equally shocking.

[Clayton Bingham, PhD @claytonsbingham]

@yael_niv @ashleyruba The suggestion that postdocs should be grateful they aren’t paying you to work for you is shocking.

I don’t know you, personally…so, I’ll say that, generally, the belief that profs are something like god’s gift to their students/postdocs is not a good look.

[Clayton Bingham, PhD @claytonsbingham]

@yael_niv @ashleyruba So, your postdocs are valuable because their ideas are so good that you don’t need to tell them what to do, but you still think they only merit trainee status/pay?

Many companies consider their employees trainees for bigger roles without undervaluing them in their current one.

[Clayton Bingham, PhD @claytonsbingham]

@Bluefishdude @sofiavanmoorsel About half of the 50k US postdocs will try to cram themselves into those 50 tweets.

[Clayton Bingham, PhD @claytonsbingham]

Pilot study of responsive nucleus accumbens (NA) deep brain stimulation for loss-of-control eating

“[When] the device sensed NA signals that had been found to predict food cravings, it automatically stimulated that region, disrupting the craving signals” https://t.co/JeqS1fmhkH

[Clayton Bingham, PhD @claytonsbingham]

“We developed Comprehensive Analysis of Tissues across Scales (CATS),…to densely map brain tissue architecture from millimeter regional to nanoscopic synaptic scales in diverse chemically fixed brain preparations, including rodent and human”

https://t.co/ROO1lYknlV

[Clayton Bingham, PhD @claytonsbingham]

@RichCompNeuro @AcademicChatter @OpenAcademics Sounds like someone is gearing up for faculty search season…me too! Care to swap?

[Clayton Bingham, PhD @claytonsbingham]

Bonus methods insight: these conclusions were not possible without realistic branching near sites of stimulation...this anatomical detail cannot be captured with dwMRI-tractography alone. Generative methods provide a means of combining invasive and non-invasive neuroanatomy. 6/6

[Clayton Bingham, PhD @claytonsbingham]

It's time for me to explain what this paper was about:

Activation of the hyperdirect pathway (HDP) is thought to be one therapeutic mechanism of subthalamic DBS, and many have assumed HDP activity can readily be observed in fast cortical evoked potentials! 1/5

[JNP @JNeurophysiol]

New research in #JNeurophysiol "Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway" by Clayton S. Bingham & Cameron C. McIntyre
https://t.co/jiAVMGWQAU
@claytonsbingham #BasalGanglia #SubthalamicNucleus #MotorCortex #Axon

[Clayton Bingham, PhD @claytonsbingham]

Thus, cortical EPs currently being used as evidence of HDP activity are likely highly contaminated by direct recruitment of capsular fibers, many of which may not bear collaterals to the STN at all! 5/6