Ondine Cleaver

Molecular biology, development, cell renewal & differentiation, stem & progenitor cells. Center for Regenerative Science & Medicine. Meet me in the sky.

[Ondine Cleaver @cleaverlab]

Calling all vascular biologists! Join us for cutting edge science at #Angioscience26 in gorgeous Seeon, Bavaria.

Awesome speakers, intimate setting, many talks from abstracts. Deadline June 15th to register! https://t.co/jqmcd7GnGq

[Ondine Cleaver @cleaverlab]

@bikohcello We have a fantastic community. Thanks to YOU for coming and sharing your work! Can't wait until Seeon 2028!

[Ondine Cleaver @cleaverlab]

Hear Lena Claesson-Welsh at #Angioscience26!

Lena fundamentally advanced vascular biology by uncovering how VEGFR signaling, junctional dynamics & proteins like CD93 regulate endothelial permeability & vessel leakage in tumor metastasis & inflammatory diseases.

Join us!

[Ondine Cleaver @cleaverlab]

Come hear Anne Eichmann at #Angioscience26!

Anne not only elucidated neuronal cue guidance of angiogenesis, but also how sensing of hemodynamic flow via Piezo1 can go awry leading to vascular malformations & how ROCK is critical to vessel stability.

https://t.co/8jK6hSShbT

[Ondine Cleaver @cleaverlab]

Hear Pipsa Sararinen at #Angioscience26!

Pipsa studies endothelial junctions & vascular stability. She showed how Ang-2 drives endothelial destabilization via beta1-integrin & targeting b1-integrin can inhibit capillary leakage in diseases like sepsis.
https://t.co/7OSSpPtDEO

[Ondine Cleaver @cleaverlab]

@PetrovaLab

[Ondine Cleaver @cleaverlab]

Hear Tatiana Petrova at #Angiogenesis26!

Tatiana studies lymphatic vascular development & tissue-specific remodeling, showing how Prox1, organ-specific mechanical forces & metabolic pathways govern lymphatic endothelial identity & functional maturation.

Register today!

[Ondine Cleaver @cleaverlab]

Come hear Stefania Nicoli @NicoliLab at #Angioscience26!

Stefania examines how non-coding RNAs integrate metabolic & biomechanical signals to regulate cell behavior in cardiovascular development & disease. 🔬

Register today! https://t.co/2NLo0zpatE...

[Ondine Cleaver @cleaverlab]

Hear Li-Kun Phng at #Angioscience26!

Li-Kun studies endothelial cell behavior during angiogenesis, revealing how cell polarity, migration, and signaling dynamics shape vascular network formation and remodeling in vivo. 🐟

Deadline tomorrow June 15th! https://t.co/2NLo0zpatE...

[Ondine Cleaver @cleaverlab]

Come hear Ben Hogan at #Angioscience26!

Ben uses high-resolution live imaging, forward genetic zebrafish screens 🐟 and single-cell transcriptomics to study lymphangiogenesis, the blood-brain barrier formation and pericyte maturation. 🔬

Deadline June 15th!

[Ondine Cleaver @cleaverlab]

Hear Shane Herbert at #Angioscience26!

@herbertlab examines how cells coordinate their behavior to build tissues, using live-cell imaging in 🐟. He showed how Notch signaling & mechanical feedback drive endothelial tip-stalk competition during sprouting.

Deadline June 15th!

[Ondine Cleaver @cleaverlab]

Hear Taija Mäkinen at #Angioscience26!

Taija studies lymphangiogenesis & showed that dermal lymphatic vasculature arises from non-venous mesenchymal progenitors. Her work has underscored lymphatic heterogeneity & lymphangiocrine signaling.

Deadline June 15th!

[Ondine Cleaver @cleaverlab]

Join us to hear Bong-Inh Koh at #Angioscience26!

Bong-Inh showed how VEGFR2 signaling drives meningeal vascular regeneration after head injury & characterized organ-specific vascular niches in craniofacial bones.

Deadline June 15th. Register today!
https://t.co/OUFntridXS

[Ondine Cleaver @cleaverlab]

Hear Maike Frye at #Angioscience26!

Maike studies how extracellular & physical microenvironments govern vessel integrity, notably demonstrating how matrix stiffness instructs lymphatic vessel formation.

Deadline June 15th. Register today!
https://t.co/OUFntridXS

[Ondine Cleaver @cleaverlab]

Join us to hear Hellmut Augustin at #Angioscience26!

Hellmut studied how Ang-Tie signaling regulates vessel maturation, stability and tumor angiogenesis & how organotypic endothelial cells control metastasis, immune responses and organ function via angiocrine signaling.

[Ondine Cleaver @cleaverlab]

Thank you to @NanionTech for your support of #Angioscience26!

[Nanion Technologies @NanionTech]

𝗧𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝗣𝗮𝘁𝗰𝗵𝗹𝗶𝗻𝗲𝗿ᵐ 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗚𝗿𝗮𝗻𝘁 𝗶𝘀 𝗵𝗲𝗿𝗲!

What if patch clamp could be fast and simple, while keeping you fully in control?

Many ion channel experiments are delayed by limited access to patch clamp equipment, resources, or expertise.

Patchlinerᵐ offers a simpler way of doing patch clamp, helping researchers accelerate experiments and record multiple cells simultaneously.

This grant is designed to help researchers explore ion channel biology, biophysics, target validation, and assay development.

The selected recipient will receive:

✔️ Patchlinerᵐ in their lab for 6 months
✔️ Full training
✔️ Consumables for the research project
✔️ Expert assay and application support

🗓️ 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗽𝗲𝗻: July 2026

Want to be the first to receive updates about the grant?

𝗥𝗲𝗴𝗶𝘀𝘁𝗲𝗿 𝘆𝗼𝘂𝗿 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁 𝘁𝗼𝗱𝗮𝘆: https://t.co/ijiYavIuhi

#PatchClamp #Electrophysiology #IonChannels #APC

[Ondine Cleaver @cleaverlab]

Thank you Hao! Steve Spurgin's awesome work looking at how endothelial cells respond differently to different types of flow!

[Hao Yin @HaoYin20]

Glenn-Fontan procedure is essential to treat Single-ventricle congenital heart disease

However, Glenn surgery▶️loss of pulmonary arterial flow pulsatility & pulmonary vascular malformation

How?🤔

Here, in this fresh-on-the-shelf @JCI_insight paper
Dr. Ondine Cleaver lab @cleaverlab😎

👉Profiles biophysical alterations of right pulmonary artery flow in a rat model of Glenn surgery
Simultaneous drop of 1⃣Velocity 2⃣Pressure 3⃣Circumferential stretch

👉Dissects the transcriptomes of pulmonary arterial endothelial cells with Pulsatile vs Non-pulsatile
1⃣Flow/Shear
2⃣Pressure
3⃣Stretch

Several intriguing findings
👉Puls. Pressure & Stretch ⏬Proteasome ⏫mTOR
👉Puls. Stretch ⏫Notch HedgeHog
👉Puls. Flow & Pressure ⏫TGFβ
👉No impact on arteriovenous differentiation

👉Mechanosensitive, Dimension-specific #Angiogcrine!!🤩

A critical in vivo relevance
Puls. Stretch-induced endothelial PDGFB maintains Pulmonary Arterial (not Venous) Smooth Muscle Cell Mass🤠

Does ECMO non-pulsatile flow cause similar mural-weakening issues?

https://t.co/EW7mFxFB8p

[Ondine Cleaver @cleaverlab]

Join us for the fantastic Kloster Seeon Angioscience meeting next September in beautiful Bavaria! From vascular formation to maintenance to angiocrine support of tissues.
Register now!

[Ondine Cleaver @cleaverlab]

Re-upping! Hoping you can join us!

Calling all cardiovascular biologists! 🫀
Registration open.

[Ondine Cleaver @cleaverlab]

🚨 SAVE-THE-DATE 🚨

SEEON ANGIOSCIENCE! Fantastic, long-running meeting on Development & Maintenance of the Vasculature.

🗓️ Sept 2026
🌍 Bavaria, Germany

Registration open! Join us!
https://t.co/OUFntridXS

[Ondine Cleaver @cleaverlab]

Please RT! :)

@HellmutAugustin
@ralfhadams
@holger_gerhardt
@BenjaminHogan13
@NicoliLab
@PetrovaLab
@bikohcello
@LabPhng
@potente_michael
@RuiBenedito_
@pipsa_saharinen
@YaleCardiology
@EVB_Org
@DonIngber
@vascbiol
@BMVBSoc

[Ondine Cleaver @cleaverlab]

🚨 SAVE-THE-DATE 🚨

SEEON ANGIOSCIENCE! Fantastic, long-running meeting on Development & Maintenance of the Vasculature.

🗓️ Sept 2026
🌍 Bavaria, Germany

Registration open! Join us!
https://t.co/OUFntridXS