Clare

[Nikki da Costa @nmdacosta]

A long shot...Last Wednesday, I left a small grey hardshell suitcase on a train from London St Pancras to Cambridge between 5-6pm

The thing in it I'm most upset about losing is a five-year journal in which I've recorded moments with my daughter (now 7) that have made me laugh or smile, and how she's changed. I like to read them back to her so she knows how precious she is.

Nothing has turned up through the train companies' lost property systems yet, and I know that may take a while, but I don't want to leave a stone unturned. Any bright ideas? Know this is a long shot. @TLRailUK @GNRailUK

[Wayside Scribbles @waysidescribble]

– Surely you can at least meet us halfway?

[George Ferman @Helios_Movement]

In case these were too complicated here are some general tips for supporting mast cell health .

1) Get more full spectrum light during the day and manage your exposure to artificial blue light after sunset.

As you are probably able to tell, this is related to melatonin.

Now in regards to mast cells, melatonin regulates/supresses signaling pathways like NF-κB and can reduce mast cell degranulation by downregulating COX-2 expression for example.

2) Avoid the following toxins (but remember, this is life, you can’t perfectly avoid everything and the attempt to do so will backfire, so always apply the 90/10 rule).

-Preservatives and additives such as sodium benzoate and polysorbate 80.

-Foods with a high chance of being contaminated with mycotoxins such as cereal, maize, nuts such a peanuts and coffee.

-Pesticides and herbicides such as endosulfan and glyphosate.

-BPA and methylisothiazolinone, (mainly used in plastics, cosmetics, shampoo and overall personal care products).

-Mercury

-PFOAs and PFOS found in things such as Teflon pans.

-Sodium fluoride.

-Over-exercising on a fasted stated.

This might seem dumbed down but it’s true: There’s a reason why no professional athlete competes at a fasted state.

There’s a big difference between going on a walk fasted or doing a short push workout on a fasted state and demanding a lot from your body.

Also there might be people who will be totally against exercise. It doesn’t work for many reasons one of them being that the right doses of lactic acid inhibit MRGPRX2 activation.

So just don’t over do it (get your steps in daily and resistance train without reaching true exhaustion).

Pointless sources of oxidative stress such as smoking for example.

3) Try to maintain a healthy bodyweight.

Besides the insulin resistance, leptin resistance and the increase of pro-inflammatory markers that can negatively affect mast cells, the increased aromatase activity could indirectly contribute to mast cell degranulation by raising estrogen levels as well.

4) Avoid things that contribute to gut dysbiosis.

Once again, this is life, you can’t perfectly avoid everything that can contribute to gut dysbiosis but we know for example that first and foremost, histamine intolerance is greatly affected by the state of our gut health, that endotoxin exacerbates mast cell activation, h. Pylori can activate mast cells, that changing the gut microbiome with a FODMAPs diet may also impact colonic mast cells.

You can also even approach this from the fact that we have so many species that produce histamine such as bacillus licheniformis A7, bacillus coagulans SL5, candida, citrobacter (koseri), lactobacillus 30a (ATCC 33222), clostridium perfringens ATCC 13124, enterobacter, enterococcus faecalis CNRZ 238, K. pneumoniae, lactobacillus buchneri ST2A, lactobacillus delbrueckii bulgaricusstaphylococcus, S. thermophilus but also species that degrade it such as, lactobacillus plantarum K-1, lactobacillus gasseri, bacteroides thetaiotaomicron, lactobacillus rhamnosus Lc705, bacteroides fragilis, bifidobacterium adolescentis, lactobacillus rhamnosus GG and more.

So avoid the “big guns” so to speak such high fructose corn syrup, artificial sweeteners, alcohol and too many lectins for example.

5) Prioritize freshly cooked meals and if you have MCAS or histamine intolerance avoid frying and grilling as well.

6) Try your vary best to relax (maybe some of the tips in the previous lessons that were about stress, will help you).

7) Avoid DAO blockers such as alcohol but even black and green tea if you are in a very compromised state.

8) Go measure your vitamin D levels since a deficiency has been linked to increased mast cell activation and degranulation.

Tools that could help you out include the following.

Note: All of these tackled multiple mechanisms and enzymes.

Quercetin for example inhibits IL-8, Fgf2, tryptase and tyrosine kinase.

-Luteolin and quercetin (unless you have a slow COMT).

Both of these are great.

-Whole food vitamin E.

Curcumin (it can decrease DAO in the long run).

-Cordyceps and DAO (this is a quite powerful combo).

Naringenin.

-P5P
Remember that histidine decarboxylase converts L-histidine to histamine with its help.

-L theanine

-Holy basil

[Clare @Clrblwrs]

@spikedonline Out of touch. There are loads of young people in bands and loads of gigs.

[Clare @Clrblwrs]

@seanstidston I think they've got dysautonomia and MCAS.

[Clare @Clrblwrs]

I think patients are not getting diagnosed with ME or CFS after a virus anymore

It's either LC or FND, going on what has happened to my family members

[Clare @Clrblwrs]

@seanstidston 1 person had many infections over 40 years, each one affecting their long term health.
Glandular fever in the 80s, flu many times, Covid once. Then recent reactions to antibiotics and steroid inhaler.

They logged into NHS app, notes said possible FND.

[Shoshana Weissmann, Sloth Committee Chair 🦥 @senatorshoshana]

Holy hell, this stat.

Akathisia is an indescribable horrible sensation of constant fear, terror, inability to sit still, and it drives people to take their own lives.

"Antipsychotic-induced akathisia (AIA) occurs in 14% to 35% of patients treated with antipsychotics and is associated with increased suicide"

That is an ENORMOUS amount of people.

[George Ferman @Helios_Movement]

Feeling anxiety physically without anxious thoughts for example, can be a common sign of histamine intolerance/MCAS.

While the average person still thinks that histamine is just something related to allergies, let’s not forget that histamine acts as a neurotransmitter in the brain, influencing things such as arousal, attention, mood, sleep, and motivation.

So when levels build up it can create:

-Restlessness and physical + mental hyperactivity

-Difficulty concentrating, brain fog, inattention

-Irritability, impulsivity, or agitation

-Sleep disturbances (insomnia or poor sleep quality)

-Anxiety or sensory sensitivities

-Hyper arousal

-Racing thoughts, anxiety/panic, or restlessness

-Insomnia or disrupted sleep cycles (common in manic phases)

-Depressive symptoms (fatigue, brain fog, low motivation) during crashes

-Emotional lability or energy fluctuations

Of course, we don’t pull all these out of our asses.

There are reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.

More:

[Gail Myerscough @GailMyerscough]

Three new prints have just been added to my shop.
Durdle Door, Eastgate Clock and the Malvern Hills.

https://t.co/5UVmSJArbR

[recovery&renewal @recover2renew]

https://t.co/TvR9zyOuLX

[Katy B @KatyBruce108]

@mermhart Lots of us here share biomedical M.E research findings
& comments from brilliant researchers, like Professor Chris Ponting from @DecodeMEstudy

[🕸️Dr.T, PhD @chydorina]

I often wonder how much of the declines we see in ME end up being due to the drugs we take to control symptoms. Steroids such as Dexamorphan are commonly used in autoimmune conditions and in acute inflammatory responses. Many common meds are mitochondrial toxins (like Metformin). Chilling.

[ℂ𝔸ℝ𝔻𝕀ℕ𝔾𝕋𝕆ℕ 𝕊ℍ𝔼𝔻𝕊 @CardingtonSheds]

97 years ago today Airship R101 overflew London on her maiden flight and overflew Highbury Stadium. #R10197

[Clean Air 2 Breathe @AirFairy04]

This #CleanAirNight share the uncomfortable truth about wood burning.
Wood burning is the most polluting way to heat your home & it's harmful to your family's health & the health of your neighbours.

Please think twice before lighting up, thank you.
https://t.co/fiNppGv3CY

[Colin Wynter KC @QcWynter]

Brilliant. Well done those young women.
The more this is done, the more it is seen, the greater the embarrassment for the absolute clowns in charge of girls' sports and the sooner will come the necessary corrections.
A fabulous and inspiring story to start the day.

[Clare @Clrblwrs]

@James_Treadwell She was told she could not have medical care unless she confessed. She could have been coerced into a false confession.

[Tim Daw @Timdaw]

Free unrestricted 1940s aerial photos of Wiltshire, mapped and linked at https://t.co/5rqBD8ooDu

[Dr Nicola Clague-Baker @ClagueNjc36]

Looking forward to @csp annual conference. Going with three MSc students - @NiamhLHeeran @ElaKlaveness @EleanorMg01 and PhD student @karenphysiocouk all presenting their work related to #ME and #LC. Raising the profile of #ME and #LC for over 1500 #physios. @PhysiosForME

[Today In History @URDailyHistory]

13 Oct 1918: 13 Oct 1918: Private Adolf Hitler is temporarily blinded by a #British mustard gas in the #Ypres Salient in #Belgium during World War I. He is evacuated to a German military hospital at Pasewalk, in Pomerania. #WWI #History (Some say it was Oct. 14. The attack evidently occurred on the night of the 13th into the morning of the 14th.) #ad https://t.co/w8OQb40V7s