What a day. This morning I defended my PhD dissertation, and this afternoon one of the key products of this work is published. Check out our new paper in @ScienceAdvances defining and exploring a dopamine induced gene expression signature in the NAc! https://t.co/W7zh35I1CB
That’s my residency lil sib @AmundamsAnatomy getting recognized as a “Be Exceptional” Awardee at @The_BMC. What a joy it’s been to work alongside her the last few weeks, learning from her compassion, grace, warmth and remarkable clinical skills. We are so proud of you!!!
New preprint alert from the lab! We identified a top-down slow breathing circuit that alleviates innate fear and anxiety without altering valence. Congratulations Dr. Jinho Jhang, and co-authors (@ShijiaLiu1, and David O'Keefe). 1/3
https://t.co/BAgPZky3Lq
Getting to sign out babies by costume to the @BrighamWomens NICU day team is an absolute treat, no tricks. 100% the place to be these last few nights. https://t.co/NVO4jZf332
Today we share in @nchembio our development of base editor scanning to chart DNA methyltransferase 3A sequence-function. Congrats to @nicklue8, @Emma_M_Garcia_1, @liaulab, & thanks to @JohnDoench! We're grateful to @DamonRunyon for invaluable support.
https://t.co/hbAP9oe3gV
Today we share in @CellCellPress a new review of current in vivo delivery technologies that have enabled therapeutic in vivo gene editing—including viral vector, lipid nanoparticle (LNP), and virus-like particle (VLP) methods—and application examples. 1/2
https://t.co/vTqins28ou
A post-publication update - our public-facing searchable web browser (available at https://t.co/PvaSBavVOV) for viewing of rat brain snRNA-seq data from brain reward structures has been updated to include count data based on the latest rat genome assembly (mRatBN7.2, aka Rn7). 1/
So wonderful to map these faces from Zoom to living bodies - absolutely loved finally meeting you all. Thank you so much for welcoming us newbies in with such warmth, grace, and kindness. Thrilled to be surrounded by such an incredible group of people!
@sydrea94 has one of the most powerful stories I know, and the impact she is already making is profound. She's an incredible person, and I know I'm not alone in my excitement to see all that she takes on and accomplishes in Chicago. Best of luck Sydney!
On National Cancer Survivors Day, we celebrate Sydney & adult survivors of childhood cancer in AL. Diagnosed with osteosarcoma at 13, she says, “I’m excited to help other kids when they go through situations like I did." We wish her the best as she begins her pediatric residency!
A year ago, a non-academic friend listened to a talk I gave. I thought it went great. My friend disagreed.
She said that academics are experts at making interesting stuff boring—and that we should all take a speech class.
So I did. And here are 6 most useful things I learned.
You grow where you’re planted — it’s the soil that makes the difference. Forever grateful to the mentors, friends, family, and patients who grew me into a physician-scientist. Thank you for teaching me what love, community, and compassion truly mean. Stay beautiful Birmingham.
What a day! Still can't believe I'm lucky enough to be moving on to @BostonChildrens for residency in child neurology @BCHNeuroRes. So grateful for all the friends, family, and mentors who made this possible for a kid from small town Oklahoma. Love you all!
MEFISTO is out in Nature Methods - a framework for dimension reduction and integration of multi-modal omics data with temporal or spatial resolution. Paper at https://t.co/bdbfE0S9wL, highlights in the thread below. (1/7)
Today we report in @CellCellPress an engineered virus-like particle (eVLP) platform that mediates efficient in vivo delivery of therapeutic proteins, including base editors and Cas9 nuclease, resulting in therapeutic editing in multiple mouse organs. 1/14
https://t.co/v1yBl296L6
Now on bioRxix, we evaluate all known human pathogenic mutations for their potential ‘treat-ability’ with antisense drugs (ASOs), based upon gene and allele. Genomic labs might want to tell patients whether a drug could help. https://t.co/o0QHkIS6tE