#MetaboliteRepair enzymes have evolved to eliminate often toxic non-canonical metabolites. Out today in @nchembio, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion https://t.co/UXksOglfQo
Happy to share this preprint of my postdoc work on discovering that CLYBL repairs malyl-CoA to avert methylmalonyl-CoA mutase inhibition and loss of vitamin B12! Thanks to the team for all your help! #MetaboliteRepair
https://t.co/b209tFbTf9
Looking forward to this afternoon's session on "Enzymatic control of problematic intermediates" at #DiscoverBMB! Three metabolite repair talks in a session - this may be a record!
(Nature MS) A spectroscopic test suggests that fragment ion structure annotations in MS/MS libraries are frequently incorrect https://t.co/UedPqpXaA3 (RSS) #nature#MassSpecRSS
The TCA cycle is fraught with metabolite damage. Here we describe a universal repair enzyme that prevents the TCA cycle from poisoning itself:
https://t.co/seoUu9cLiT
Zebrafish model for CLN3 Batten disease recapitulates the human metabolic signatures of BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at larval stages https://t.co/Uuawn1aoiE
https://t.co/NyBbJYktEo
Nice follow up by @mdtauqeer on his earlier work on enzyme inhibition https://t.co/jj5ooJHEuI, now showing how frequent metabolic enzyme activators let metabolic pathways talk to each other
@ErinBakerIMS That's absolutely devastating... I am so sorry that you all had to go through that and I am glad to hear that you all are physically safe. Be mindful and don't hesitate getting help to process this... I wish you all the best! If you need something, please let us know!
Interested in rare diseases, mitochondria, non-target mass spectrometry #TeamMassSpec#cheminformatics and identification?
Exciting #postdocposition in GENOMIT consortium with rare disease cohort at @lcsb_uni_lu@uni_lu in the Linster & Schymanski groups!
https://t.co/m5buGxR7cj
Come join us!
We are looking for a Postdoctoral Researcher in Mass Spectrometry Workflows for Unknown Chemicals to join the Environmental Cheminformatics group at @lcsb_uni_lu@uni_lu#TeamMassSpec#cheminformatics#OpenScience
Interested? Apply here⬇️
https://t.co/9VQJAbv6Kx
A real @fonia_sin led by our coordinator @PabloINik ! In front of the Opera House in the eternal city, in the occasion of our final meeting, but is it so? I doubt it 😎 we will continue playing 🙌🏻
NEW: I’m proposing the 28th Amendment to the United States Constitution to help end our nation’s gun violence crisis.
The American people are sick of Congress’ inaction.
The 28th will enshrine 4 widely supported gun safety freedoms -- while leaving the 2nd Amendment intact:
1) Raising the minimum age to purchase a gun to 21
2) Universal background checks
3) A reasonable waiting period for gun purchases
4) Banning the civilian purchase of assault weapons
Many congrats to Lorenzo and the entire team! Credentialing is a powerful yet unexploited branch of metabolomics and herein, we devised a nice approach to help tackle these projects in yeast.