Corey Griffith

Metabolic Biochemist. Interested in problems that intersect analytical chemistry, metabolism, toxicology, and the environment. 🇺🇸 in 🇱🇺

[Corey Griffith @coreymgriffith]

#MetaboliteRepair enzymes have evolved to eliminate often toxic non-canonical metabolites. Out today in @nchembio, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion https://t.co/UXksOglfQo

[Corey Griffith @coreymgriffith]

Happy to share this preprint of my postdoc work on discovering that CLYBL repairs malyl-CoA to avert methylmalonyl-CoA mutase inhibition and loss of vitamin B12! Thanks to the team for all your help! #MetaboliteRepair
https://t.co/b209tFbTf9

[Corey Griffith @coreymgriffith]

Looking forward to this afternoon's session on "Enzymatic control of problematic intermediates" at #DiscoverBMB! Three metabolite repair talks in a session - this may be a record!

[Kermit Murray @kermitmurray]

(Nature MS) A spectroscopic test suggests that fragment ion structure annotations in MS/MS libraries are frequently incorrect https://t.co/UedPqpXaA3 (RSS) #nature #MassSpecRSS

[Tom Niehaus @TomDNiehaus]

The TCA cycle is fraught with metabolite damage. Here we describe a universal repair enzyme that prevents the TCA cycle from poisoning itself:
https://t.co/seoUu9cLiT

[LifeScienceAlliance @LSAjournal]

Zebrafish model for CLN3 Batten disease recapitulates the human metabolic signatures of BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at larval stages https://t.co/Uuawn1aoiE

[Ralser Lab @RalserLab]

https://t.co/NyBbJYktEo
Nice follow up by @mdtauqeer on his earlier work on enzyme inhibition https://t.co/jj5ooJHEuI, now showing how frequent metabolic enzyme activators let metabolic pathways talk to each other

[Corey Griffith @coreymgriffith]

So very proud of my friend and colleague, Lorenzo! Congratulations! 🥳

[Emma Schymanski @ESchymanski]

Congratulations to Dr. Lorenzo Favilli - second ECI and ECHIDNA PhD graduate. We are all so proud of you!
#proudPI #metabolomics #TeamMassSpec @lcsb_uni_lu @uni_lu @FnrLux @ResearchLux
Here with Carole Linster and @coreymgriffith
Many thanks to our Jury & audience as well!

[Corey Griffith @coreymgriffith]

Congrats on the promotion @ESchymanski!! 🎉🥳

[Emma Schymanski @ESchymanski]

What a great team!
#environmental #cheminformatics @lcsb_uni_lu

@EmmaPalm4 @DagnyAurich Federica Vero @HibaMohamedTaha @AnjuAnjuraj15 @Begotalavera9 Camilla @PChirsir Lorenzo @coreymgriffith (out of pic @GianfrancoFrig1 )

[Emma Schymanski @ESchymanski]

What a great team!
#environmental #cheminformatics @lcsb_uni_lu

@EmmaPalm4 @DagnyAurich Federica Vero @HibaMohamedTaha @AnjuAnjuraj15 @Begotalavera9 Camilla @PChirsir Lorenzo @coreymgriffith (out of pic @GianfrancoFrig1 )

[Corey Griffith @coreymgriffith]

@ErinBakerIMS That's absolutely devastating... I am so sorry that you all had to go through that and I am glad to hear that you all are physically safe. Be mindful and don't hesitate getting help to process this... I wish you all the best! If you need something, please let us know!

[Emma Schymanski @ESchymanski]

Interested in rare diseases, mitochondria, non-target mass spectrometry #TeamMassSpec #cheminformatics and identification?
Exciting #postdocposition in GENOMIT consortium with rare disease cohort at @lcsb_uni_lu @uni_lu in the Linster & Schymanski groups!

https://t.co/m5buGxR7cj

[Emma Schymanski @ESchymanski]

Come join us!
We are looking for a Postdoctoral Researcher in Mass Spectrometry Workflows for Unknown Chemicals to join the Environmental Cheminformatics group at @lcsb_uni_lu @uni_lu
#TeamMassSpec #cheminformatics #OpenScience
Interested? Apply here⬇️
https://t.co/9VQJAbv6Kx

[Anal Bioanal Chem @AnalBioanalChem]

High-throughput Saccharomyces cerevisiae cultivation method for credentialing-based untargeted #metabolomics
by Lorenzo Favilli et al @lcsb_uni_lu @uni_lu @ESchymanski @coreymgriffith #yeast #chromatography #labelling #spectrometry

#OpenAccess
https://t.co/H6IkBcB3Ra

[Corey Griffith @coreymgriffith]

@ESchymanski @lcsb_uni_lu @uni_lu @microh_dtu That's me!! 😅

[laura martinelli @martinelli7512]

A real @fonia_sin led by our coordinator @PabloINik ! In front of the Opera House in the eternal city, in the occasion of our final meeting, but is it so? I doubt it 😎 we will continue playing 🙌🏻

[Corey Griffith @coreymgriffith]

Come be a split EM/ECI postdoc like me! This is a very cool project for those interested in unknown identification.

[Corey Griffith @coreymgriffith]

Pass this immediately!

[Gavin Newsom @GavinNewsom]

NEW: I’m proposing the 28th Amendment to the United States Constitution to help end our nation’s gun violence crisis.

The American people are sick of Congress’ inaction.

The 28th will enshrine 4 widely supported gun safety freedoms -- while leaving the 2nd Amendment intact:

1) Raising the minimum age to purchase a gun to 21

2) Universal background checks

3) A reasonable waiting period for gun purchases

4) Banning the civilian purchase of assault weapons

[Anal Bioanal Chem @AnalBioanalChem]

Thank you very much @ESchymanski @coreymgriffith Lorenzo and Carole for submitting your work to ABC!
@GNPS_UCSD @lcsb_uni_lu @uni_lu @FnrLux #metabolomics

[Corey Griffith @coreymgriffith]

Many congrats to Lorenzo and the entire team! Credentialing is a powerful yet unexploited branch of metabolomics and herein, we devised a nice approach to help tackle these projects in yeast.

[Emma Schymanski @ESchymanski]

Super #proudPI tonight to see Lorenzo's work with Carole Linster and @coreymgriffith now published - high throughput stable labeling approach for untargeted metabolomics in yeast, all data in @GNPS_UCSD and more!
@lcsb_uni_lu @uni_lu @FnrLux #OpenScience

https://t.co/ZW7IP8Lk9S