Cmo

[V8 Law @2__LC]

Bro a real one thru an thru

[Cmo @CoreyPilot]

@Montrell1223 @4KTSwervo This is how I feel.

[Dalton (Analyze & Optimize) @Outdoctrination]

Depression isn't some unknown genetic condition like your doctor tells you.

In fact, we know the exact biological causes behind it.

Here are 10 hallmarks of depression, & what you might be able to do about each:

#1 NUTRIENT DEFICIENCIES

If your brain doesn't have the tools needed to function, how can you expect to be happy?

One of the most common nutrient deficiencies is magnesium.

Having high magnesium levels literally cut depression risk by more than half.

Magnesium reversed major depression within a week in a stunning case series.

Very reasonable (125-300 mg) doses of magnesium glycinate or taurinate had this incredible effect.

Magnesium:

◇ Acts as a calming agent
◇ Prevents brain cell death
◇ Aids in energy production

Crucial at every level.

Another common nutrient deficiency in depression is VITAMIN D.

Vitamin D completely abolishes severe depression.

Low vitamin D more than doubles the risk of depression.

Everyone should know this.

Vitamin D was shown to cut suicide risk in half in a critical trial.

◇ Promotes brain cell differentiation
◇ Anti-inflammatory
◇ Protects against calcium toxicity

How many people get their levels checked before their doc gives them an "antidepressant" drug?

#2 LEAKY GUT

Yep, one of the biggest hallmarks of depression actually is in the gut.

Individuals with "unexplained" major depressive disorder have elevated levels of every marker of dysbiosis and intestinal inflammation measured.

This inflammation becomes a whole body problem.

Healing the gut cuts depression + anxiety in half in studies.

One showed 2 months of probiotics + prebiotics:

• Drastically reduces depression / anxiety metrics
• Reduces leaky gut
• Lowers systemic inflammation
• Improves quality of life
• Increases BDNF (brain cell growth)

#3 HIGH CORTISOL

Another hallmark of depression, this should come as no surprise since the vast majority of depression cases start with a stressful event.

The higher the cortisol / stress, the worse the depression.

Improvements are proportional to cortisol reduction.

Aging & depression are associated with higher cortisol activity,

but flatter rhythms throughout the day.

There is also a lack of ability to shut off cortisol secretion.

Both are a loss of sensitivity of the hypothalamus - pituitary - adrenal (HPA) axis from chronic stress.

#4 GLYMPHATIC DYSFUNCTION

The glymphatic system is essentially the waste management company of the brain.

It clears out all sorts of toxins / inflammatory proteins from the brain.

If it's not cleaning these out properly, the health of the brain is highly compromised.

#5 HIGH INFLAMMATION

Inflammatory markers are higher across the board, sometimes by 2-3X, in depressed people.

It's toxic to every part of your brain.

Anti-inflammatories:

�� Aspirin
• Taurine
• Pregnenolone/progesterone
• Red light
• Glycine

etc

should be explored.

#6 HYPOTHYROIDISM

Among people with depression, one study showed:

⬩Subnormal T3 (active thyroid hormone) in 90.6%
⬩T3 lower by ~60%
⬩High TSH levels in 18.7%
⬩Low T3 in 93.3% of moderate/severe grade
⬩High TSH in 54.5% of severe grade

Natural desiccated thyroid treated it before pharma.

Thyroid hormone reverses depression, by normalizing brain energy.

Many people with depression have low:

• ATP
• Magnesium

in the brain - indicating impaired energy production.

Thyroid hormone (T3) improves energy generation, and reverses depression in ~1/3-1/2 of patients.

#7 IMPAIRED GLUCOSE METABOLISM

Depression could be described as diabetes of the brain.

Worsened glucose metabolism is found in the cerebral cortex in depression.

A high energy brain is a happy / healthy brain.

Methylene blue is a potent antidepressant.

Just 15 mg / d for 3 weeks improved ALL measures of depression in one trial,

some by ~50%.

Methylene blue primarily works by enhancing glucose metabolism, which is lacking in depression.

#8 IMPAIRED NEUROGENESIS

Depression can literally be the brain crying for help as it dies.

The protein BDNF helps in brain cell growth and survival.

and is LOW in people with depression.

Most conventional antidepressants work by increasing BDNF (if they work at all).

Brain cell death in depression.

A decline in the grey matter of the brain directly predicts depressed symptoms.

Some ways to protect:

⬩Vitamin E
⬩Vitamin K2
⬩Vitamin B1
⬩Pregnenolone
⬩Progesterone
⬩Methylene blue

#9 HIGH GLUTAMATE

Glutamate is the primary "excitatory" neurotransmitter, increasing brain activity.

This is obviously very important but high glutamate can directly contribute to the death of brain cells.

Things that reduce glutamate can have antidepressant effects.

N-Acetylcysteine cut depression by >60%, anxiety by 50% in one study.

1.2 g per day.

Excess glutamate in distinct brain regions can contribute to these feelings.

NAC's ability to lower it in the ventrolateral prefrontal cortex contributes to its antidepressant and anti-anxiety effects.

#10 IMPAIRED CEREBRAL BLOODFLOW

The cerebral cortex is the "higher thinking" brain region, associated with deep thought and consciousness.

Reduced blood flow to this region literally suffocates your brain, depleting oxygen and thus energy production.

This can also cause damage to the brain.

Red / near infrared light therapy completely reversed depression in one trial.

People applying 823 nm light (20-30 min, 2x a week for 8 weeks) saw their depression metrics drop to normal levels.

Improvement by >60%.

This type of light stimulates cerebral blood flow (among other things).

Clearly, depression is a symptom of poor overall health.

[fresils @iFresils]

please, wear your nice clothes everyday. the special occasion is being alive.

[Melodies & Masterpieces @SVG__Collection]

“Anybody can play. The note is only 20 percent. The attitude of the motherfucker who plays it is 80 percent.”

— Miles Davis

[peebs @sirpeebs]

@AmericaPapaBear A lot of people don’t know that Bass Pro shop actually uses their aquarium to qualify as a “museum” which allows for all kinds of tax breaks as opposed to being a standard retail store. Just a fun fact.

[Coach Tre' Sullivan @_TreFIVE]

Sheesh!!!

[Simply AJ aka Tom Bombadil @SimplyAJ144]

All bc she packed her husbands big ass lunch 😂😂😂

[Trailer_Swift @GoonNRG]

@t_sadiity When you’re on assistance, you can’t work. It’s a trap. But you can also get FREE tuition. Go to school in a trade and get tf out!

[Black Girl @t_sadiity]

yall don’t think it’s WEIRD , that CPS will potentially take your kids if you’re struggling (unable to feed them , clothe them , pay for necessary medicines , etc.) 🤔 and then once your kids are taken , they put them in a home with another family , and then give THEM money every month to take care of your kids ??

is that not a fucked up system ?!

[Washington Commanders @Commanders]

oh hell nah part two 😭

[HoodiDavis @HoodiDavis]

Bron was out there doing shit just to see what happens 😭

[Nature 🦜and Music 🎶 @GuGi263]

His instincts to enter the water silently with no splashes are amazing, that is fundamental for Jaguars in the wild since they do a large part of their hunting in the water.

[𓍝 @solovisios]

Wemby to Carter Bryant: “I’m proud of you” 🥹

[Bobcat02 ◎ @TxBobcat02]

@elonmusk Coming Soon:

[Washington Wizards @WashWizards]

🗣️ D.C. STAND UP!!!!!

[Complex Sports @ComplexSports]

Wizards fans after the bball gods blessed em w/ the No. 1 pick

[🧙‍♂️ @D_whit98]

John so real for doing this for us on Mothers Day..RIP to Ms.Frances Pulley!

[L E S E D I @_Hybreed_]

God, please remove the spirit of laziness when it comes to praying, hustling & studying.