Jake Smith

doing some science | using cryo-ET to study tissues in situ ❄️🔬 | @OxCellStruBio @RosFrankInst

[Jake Smith @crying_EM]

🙃

[Jake Smith @crying_EM]

@rgsheld @glynnca93 thanks a lot Richard :)!

[Jake Smith @crying_EM]

After thousands of microscope hours and several years of painstaking optimisation, @glynnca93 and I are very excited to share our latest manuscript. We outline our approach to investigate the molecular organisation within hippocampus tissue using cryo-ET.

[Jake Smith @crying_EM]

@JennySachweh @glynnca93 thanks Jenny :)

[Jake Smith @crying_EM]

@cryingem.bsky.social for further documentation

[Jake Smith @crying_EM]

cryo lift out: a summary

[Jake Smith @crying_EM]

it was great to share some results from mine & @glynnca93's latest preprint! It has been an interesting meeting with plenty of overlap between different imaging modalities/sample prep disciplines. Lots of insightful discussion/ideas!🔬
@VolumeEM1

[Rosalind Franklin Institute @RosFrankInst]

Jake Smith (@crying_EM), PhD student at the Franklin and @UniofOxford , gave a fascinating talk this afternoon about his PhD work studying the hippocampus using cryo-EM as part of the vEM Technology Forum's Cryo FIB-SEM Methods Development Session. #vEMTechForum2024 @VolumeEM1

[Jake Smith @crying_EM]

cool tie @ the bear

[Jake Smith @crying_EM]

A huge shoutout to the rest of the team at the Franklin for making this happen.

And of course the biggest shoutout to Michael Grange (now twitter-less) for steering the ship🫡.

On to the next one 👀🧠🔬

[Jake Smith @crying_EM]

We hope that our structural and cell biology friends can adapt our approach to their favourite tissue biology question.

To find out more, please check out our preprint: https://t.co/4SIVP29qEZ

#teamtomo #LiftLaughLove

[Jake Smith @crying_EM]

@JennySachweh @Beck_Laboratory @svenklumpe @MandyBoermel @WilflingFlorian congrats, Jenny!

[Jake Smith @crying_EM]

15 years later

nothing has changed...

[Jake Smith @crying_EM]

watching the 3DEM mailing list:

[Dominik Hrebik @F4ustus]

Subtomogram averaging from lamellae

[Jake Smith @crying_EM]

@lovattscience @drrenefrank @TJRyan_77 @Clrar woo!! congrats, Charlie!!!🧠

[Yong Xiong Lab @Xiongosome]

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!

https://t.co/ScWOAQRjTw