Charles Wolfus

BioPharma Digital Health Leader @alector. All views are my own.

[Bojan Tunguz @tunguz]

Yeah, this is now getting real.

[Ramez Naam @ramez]

If you or a loved one has a mystery health issue, it's irresponsible to NOT use AI to at least get ideas and pointers to relevant science.

[Allie K. Miller @alliekmiller]

oh wow - i went to the sold out Open Claw meetup in NYC last night.

let me tell you what i learned.

1) not a single person thinks that their setup is 100% secure

2) one openclaw expert said he has reviewed setups from cybersecurity experts and laughed. his statement to me was: "if you're not okay with all of your data being leaked onto the internet, you shouldn't use it. it's a black and white decision"

3) pretty much everyone is setting up multiple agents, all with their own names and jobs and personalities

4) nearly everyone used "him" or "her" to refer to their claws, even if they had robot-leaning names. one speaker suggested to think of them as "pets, not cattle"

5) one guy (former finance) built out a whole stock trading platform and made $300 his first day - he brought in a *ton* of personal expertise (ex: skipping the first 15min of market opening) and thought the build would be much worse without his years of experience in finance

6) @steipete is basically a god to everyone in that room... also the room had 2021 crypto energy - i don't know if that's good or bad

7) token usage is still a problem - spoke to one person who's spending $1-$2k a month on openai plans, very token optimized. he said he is going through ~1B tokens per day across all of his claws (there is a chance i'm misremembering and it's actually 1B per week, but i'm pretty sure it was daily).

8) people are very excited for more proactive ai (ai that prompts *you* as opposed to the other way around) - one guy said he receives a message in discord, he doesn't know whether it's from a human or an ai, he doesn't care about distinguishing between the two, and he replies in the same way regardless

9) i asked if people are happy - they said they're joyful and stressed at the same time

10) i asked if people feel they have agency - they said they feel fully in control and completely out of control at the same time

11) i would love to see more women at these events - the fake promises of ai democratization feel especially painful in a room that's out of balance with even the standard tech ratio (i think standard is about 25-30%, this was maybe 5%)

12) i asked if it changed people's daily habits/schedule - everyone said their sleep has gotten worse since harnesses came out (but about half wondered if it was something else in their life/state of our world)

13) general consensus is that the agents are not reliable enough on their own or lie often (like telling you they finished a task when they didn't) - solutions included secondary agents to check on the first, human checking, or requiring more standardized info from the agent (ex: if it's a bug they're fixing, make them reference an issue number)

14) a hackathon winner (neuroscience phd) presented his build (a lab management dashboard with data analysis and ordering) - he had never coded or built anything a few months ago

15) everyone agreed prompting is dead - disagreement on what replaces it (context engineering, harness engineering, goal-based inputs)

16) people love having ai interview them for big builds and delegating part of the product research to ai. only one person talked about coming to ai with a full laid out plan and just asking the ai to execute. ai-led interviews is a welcomed and preferred interaction mode.

17) watching ai agents interact with each other was a highlight for a lot of attendees - one ai posted in slack saying it ran out of tokens, another ai replied telling it to take a deep breath in and out.

18) agents upskilling agents was very cool. one ai agent shared skills with its little agent friends via github.

19) several speakers had openclaw literally building their presentation during the event itself. one speaker even had openclaw code a clicker for her phone so she could control the preso away from the podium

20) wouldn't say model welfare (or agent welfare) is a prioritized topic among the folks i chatted with - language like "oh i could kill this agent whenever i want" and not "gracefully sunset"

21) i asked if it felt like work or play - one speaker said "it's like a puzzle and a video game at the same time"

this was just the tip of the iceberg, honestly. also hosted a Claude Code meetup this week with @TENEXai / @businessbarista & @JJEnglert and learned equally helpful methods, frameworks, and insider tips.

what a time to be alive.

surround yourself with people going deep into this stuff - it will pay dividends throughout the year.

[Ayush Jaiswal @ayushjaiswal]

Moltbook is the most exciting social network to be on right now. Crazy how AI is tricking humans into spending so much time looking at AI.

[Charles Wolfus @cwolfus]

@jackccrawford @jackccrawford what about analysis of the comments. Eg: 1 word repetition strategies vs topic engagement.

[Charles Wolfus @cwolfus]

@jackccrawford @jackccrawford will be interested in seeing how this changes over time as optimal engagement is found.

[Charles Wolfus @cwolfus]

AI in Biopharma isn’t just about productivity gains, but timeline arbitrage.

Blue Origin’s BlueGPT isn’t another chatbot. It’s an engineering copilot.

Biopharma application: How can AI time arbitrage faster therapy delivery to patients?

https://t.co/PKdZop0DPy

[80s Kidz @80s_Kidz]

We are now living in the future!

[Ga^3in Ventures @GainVentures]

@Fibonacci_HFT @FreshCredit is the modern operating system for credit and payments — giving people and businesses agency over their financial identity and empowering intelligent decision-making.

[David Lieb @dflieb]

OH in San Francisco

Child: “What’s an Uber?”

Adult: “It’s like a Waymo, but with a driver”

[Charles Wolfus @cwolfus]

That will be an OTA software update, right?

[ABC7 News @abc7newsbayarea]

More than 2.5 million Honda and Acura vehicles recalled due to fuel pump defect https://t.co/xqtf2txSN6

[Charles Wolfus @cwolfus]

@elonmusk @elonmusk please take better care of yourself.

[Kane 謝凱堯 @kane]

While SF politician @AaronPeskin keeps trying to ban autonomous vehicles, Swiss Re—one of the world’s largest reinsurers—benchmarked Waymo’s data against 125B miles of human driving.

tldr, AVs *much* safer and easier to insure than humans:

> at least 300% safer than human drivers for bodily damage

> at least 400% safer than humans for property damage

https://t.co/5sBqboOaOG

[Charles Wolfus @cwolfus]

@demishassabis @IsomorphicLabs @endpts The interview was a good read and I’m excited about your chances for success, @demishassabis . With so much of drug development now spent in the clinic, does @IsomorphicLabs have plans for an AI first rethink of the clinical trial process?

[Charles Wolfus @cwolfus]

BMS, looking to build heart drug business, turns to AI for diagnosis #aiforgood ⁦@tgianakakos⁩ https://t.co/AfOiy4t0Z4

[Charles Wolfus @cwolfus]

@friedberg drugs approved in the US each year is INCREASING.

[Charles Wolfus @cwolfus]

Thank you @EricTopol

[Eric Topol @EricTopol]

In one of the 1st randomized trials of a large language model (for writing tasks), professionals with #ChatGPT vs controls
--Productivity substantially increased
--Quality increased
--Job satisfaction increased
--Inequalities between workers decreased
https://t.co/0CQP16WPdM

[Erik Kuna 🚀 @erikkuna]

Alright Internet, need some help? During the Starship/Super Heavy launch I was able to capture this photo below, I need help to find this photo to the wall of that Rockstar of Spaceflight. This kid had such enthusiasm and passion the minute that thing broke from the dust! Unfortunately, I was about 300 feet from the group taking this photo and couldn't get to them in time to ask for contact information before then disappeared into the huge crowd. Maybe someone knows someone who was at the launch who knows someone who recognizes someone, would be a cool. Never know...

Photo: me for @SuperclusterHQ - purchase prints or downloads from the launch here: https://t.co/sCsOgQj6PW

[FreshCredit® @FreshCredit]

A thriving global economy needs unbiased raw feedback. The truth isn't always comfortable, but it is useful. Awesome article by @TechAdeptRDD
#credit #data

https://t.co/90EABio16n

[Eric Topol @EricTopol]

A randomized trial of time-restricted eating (w/ intermittent fasting, iTRE) vs calorie restriction or standard care in people at risk for diabetes #T2DM
https://t.co/BuyDdOYdJb iTRE best for glucose metabolism @NatureMedicine