Diego A. Cruz Aguilar

PhD student trying to harness H-Bond organocatalysis in organic synthesis @iquimicaunam

[Diego A. Cruz Aguilar @da_cruzag]

Out now in @JOC_OL! We found that silyl ketene acetals and electron deficient nitrostyrenes react via an unexpected radical pathway to form anti-Michael products.
@iquimicaunam #JOrgChem #OrganicChemistry #OpenAccess
https://t.co/9xN6K3l62R

[enrique. @E_Rod5]

We’re excited to share our latest paper in @Synthesis_1969! A metal-free radical cascade enables indole dearomatization → spiroindolines. Xanthate chemistry from esters, nitriles, ketones & lactones → enamides in 1 pot! @LuisDemetrio_M @mario_garciacst @iquimicaunam

[Diego A. Cruz Aguilar @da_cruzag]

@OxytocinLau Yo sospecho que es ninhidrina. Además de tener el color, el reactivo se prepara con cierta cantidad de ácido acetico.

[J Org Chem/Org Lett @JOC_OL]

An elegant approach to furan-fused naphthopyrones and application to the synthesis of (+)-lasionectrin and its C12-epimer is reported by the group of Sartillo-Piscil (@fergotico). Please have a look: https://t.co/9LZFAcEkjk

[Porcel Group @ThePorcelGroup]

Delighted to share our new work on "Oxy- and Chloroarylation Pathways in Gold-Mediated Cyclization of 2-Aminoaryl-3-arylpropargyl-benzenesulfonamides", now online in @ChemEurJ.

@iquimicaunam @LatinXChem

[Diego A. Cruz Aguilar @da_cruzag]

@julia_ur1 @LatinXChem @GroupGamba @OrgBiomolChem @EurJOC Nice work! Do you have any thoughts about why is ethanol considerably less effective than methanol? Do you think the pressure generated or the ammonium salt solubility might be playing a role?

[Diego A. Cruz Aguilar @da_cruzag]

@Resendizlab @LatinXChem @OrgBiomolChem @EurJOC @beyondbenign @green_rsc @RSC_Sus @marcoshrdz @iquimicaunam 4) Not yet. But we're aiming to produce derivatives involving further transformation of 1-IMs and test them for various biological activities. Certainly, the reduction of the nitro group will be studied.

[Diego A. Cruz Aguilar @da_cruzag]

Hi @LatinXChem, presenting my work "Stereoselective synthesis of highly substituted 1-isomorphans" at #LatinXChem23 #LatinXChemOrg #Org052 @OrgBiomolChem @EurJOC @beyondbenign @green_rsc @RSC_Sus
Link to paper in thread

[Diego A. Cruz Aguilar @da_cruzag]

@Resendizlab @LatinXChem @OrgBiomolChem @EurJOC @beyondbenign @green_rsc @RSC_Sus @marcoshrdz @iquimicaunam 2) Epimers were assigned by analyzing the alcohol CH 1H-1H constant couplings (H6 in the figure below). In compounds 7 two gauche couplings cause a broad H6 signal. In compounds 6, gauche and anti couplings produce a dd H6 signal.
3) Not yet, unfortunately

[Diego A. Cruz Aguilar @da_cruzag]

@Resendizlab @LatinXChem @OrgBiomolChem @EurJOC @beyondbenign @green_rsc @RSC_Sus @marcoshrdz @iquimicaunam Thank you!
Answering your questions:
1) R1 doesn't need an Ar group, as the adduct from the isopropyl-substituted nitroalkene was obtained with high selectivity. However, this was not included due to some purification issues around this example. Future work will address this.

[AngelRT @ramangeltrix]

Hi @LatinXChem this is my work "DOS of 2-arylimidazo[1,2-a]pyrimidines and its potential application as antimicrobials" as part of #LatinXChem23 in the category of #LatinXChemOrg with number #Org107
@OrgBiomolChem @EurJOC @iquimicaunam @quimica_unam

[Diego A. Cruz Aguilar @da_cruzag]

@r________n31h9c @LatinXChem @EurJOC A really nice work!
How did you know there was a configuration retention after the diazotization/bromination step in Scheme 2? Was it a complete retention?

[Diego A. Cruz Aguilar @da_cruzag]

@avegap_p @LatinXChem @OrgBiomolChem @EurJOC @beyondbenign @green_rsc @RSC_Sus @marcoshrdz @iquimicaunam Thanks, Alberto!
We did a quick study with Li, Na and NMe4 borohydrides, and with CaCl2 as additive. CaCl2 favors one epimer, whereas NMe4 favors the other one. It might be due to chelation during TS, but other factors seems to be at play, so more work is needed.

[Yoarhy ALejandro @yoarhy098]

Hi @LatinXChem ! here is my work "Remote Control of CsPbBr3 Nanocrystal Morphology" at #LatinXChem23 #LatinXChemNanoMat #NanoMat043 @nanoscale_rsc @PerovskitesMX

[Howard Díaz @Hwdiaz24]

Hi @LatinXChem, presenting my work 'Oxy- and Chloroarylation Pathways in Gold-Mediated Cyclization of N-propargyl sulfonamides' at #LatinXChem23 #LatinXChemOrg #Org170.
@EurJOC @Wiley_Chemistry @ChemEurope @OrgChemFront @OrgBiomolChem

Looking forward to your questions!

[Josué Vazquez @Chavez_JVaz]

Hi @LatinXChem, this is my work title"SYNTHESIS, NMR CHARACTERIZATION AND CYTOTOXIC ACTIVITY OF HYBRID SPIROSTANIC SAPOGENINS ESTRADIOL DIMERS" at #LatinXChem23 #LatinXChemOrg #Org33. @LabSteroids @OrgBiomolChem @EurJOC

[Diego A. Cruz Aguilar @da_cruzag]

NOESY and isomorphan 7c in 3D

[Diego A. Cruz Aguilar @da_cruzag]

You can read the paper published for this work at: https://t.co/ZSKN2yxXLv

[Diego A. Cruz Aguilar @da_cruzag]

@VictorKiryak Top left, as the hat, bow tie and shirt could be seen as asymmetric elements. It would be perfect if the cats wore a monocle

[Diego A. Cruz Aguilar @da_cruzag]

@TheStrugglingS4 Not in a bakery, but in a wood workshop