Elena Daoud

Neuropathology Instructor at UT Southwestern

[Elena Daoud @daoud_elena]

Autopsy brain of an immunocompromised patient. Diagnosis?

[Elena Daoud @daoud_elena]

@jme_walker What a pretty piece!

[UTSW Department of Pathology @UTSW_Pathology]

A new publication by our UTSW neuropathology faculty members: The efficacy of immunohistochemistry in the diagnosis of molecular genetic alterations in central nervous system gliomas: Next-generation sequencing of 212 mutations in 112 patients.
DOI: 10.5414/NP301381

[Elena Daoud @daoud_elena]

@RatiChkheidze @BrainIsThePath @bluehatcomics85 @TNRLab @jme_walker @UABPathology @Suey99 @Alex_Feldman_MD @bcmmd12 @badbrainstrains @M_B_Miller @CraigHorbinski @BrainsSlicer @neuropathology @MaggieFlanagan You need a picture!

[Elena Daoud @daoud_elena]

@icewatervapour @UTSW_Pathology Thank you for sharing this paper. Fascinating!

[Elena Daoud @daoud_elena]

Cauda equina tumor - we don't see this one very often. Can you guess the diagnosis? @UTSW_Pathology

[Elena Daoud @daoud_elena]

Arteriovenous malformation: vessels of variable caliber and wall thickness, with intervening brain, clinically hemorrhagic. Note reactive gliosis in intervening brain parenchyma. @UTSW_Pathology

[Elena Daoud @daoud_elena]

@anjuthevirgo @UTSW_Pathology YES

[Elena Daoud @daoud_elena]

@Fireneh @UTSW_Pathology YES

[Elena Daoud @daoud_elena]

@AlcinoGama @UTSW_Pathology We would be able to rule this one out with stains.

[Elena Daoud @daoud_elena]

@maahahah @UTSW_Pathology Bingo! Positive

[Elena Daoud @daoud_elena]

@UTSW_Pathology Paraganglioma! Epithelioid chief cells arranged in tight nests (Zellballen pattern) with salt-and-pepper chromatin, stain with neuroendocrine markers and keratin. Surrounding sustentacular cells stain with S-100. Stains not shown.

[Elena Daoud @daoud_elena]

Nice case of microcystic meningioma, one of the 3 vascular-rich meningioma variants (others are angiomatous and clear cell variants)
@UTSW_Pathology

[Elena Daoud @daoud_elena]

This is Coccidioides which is endemic in southern USA, Central and South America. CNS presentation is basal meningitis, paravertebral abscess, or intracerebral lesions. Large yeast ~40 um diameter containing numerous tiny endospores here. Thanks for the differentials!

[Elena Daoud @daoud_elena]

Brain of an immunocompromised patient. What do you think this is?

[Elena Daoud @daoud_elena]

@maahahah Yes the patient is from southwestern US, and it is endemic here.

[Elena Daoud @daoud_elena]

@NorganAndrew Granulomatous parenchymal reaction in an immunocompromised patient certainly raises a possibility of Blasto. The fungi are ~8-15 um diameter with a typically broad-based budding, which is not seen in this case. There should also not be endospores like we see in this case.

[Elena Daoud @daoud_elena]

@SuntreaHammer Strongy most commonly presents as a purulent meningitis (I didn’t explicitly say this is brain parenchyma). When filariform larvae are present, microinfarcts can occur from small vessel occlusion. Granulomatous inflammation can also occur in some cases, so this is a fair guess!

[Elena Daoud @daoud_elena]

@ricardocedenomd Granulomatous parenchymal reaction in an immunocompromised patient certainly raises a possibility of Blasto. The fungi are ~8-15 um diameter with typically broad-based budding, which is not seen in this case. There should also not be endospores like we see in this case.

[UTSW Department of Pathology @UTSW_Pathology]

Welcome new @UTSW_Pathology faculty! We are thrilled to have them join our team! 🔬🎉

Brian Adkins, MD @path_brian
Elena Daoud, MD, PhD @daoud_elena
Anne McLean-Holden, DMD, MS @AnnieMcLeanDMD
Jing Xu, MD, PhD