David Florenz @davesolardude - Twitter Profile

5 days ago

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? @joerogan @davidasinclair

KanekoaTheGreat

@KanekoaTheGreat

5 days ago

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” ��We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? @joerogan @davidasinclair

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David Florenz

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