David B Sauer

Membrane Transporters, Ion Channels, Structural Biology, Bioinformatics... and other bits of fun

Purdue BS, UTSW PhD, NYUSoM PostDoc, Univ. of Oxford PI

[David B Sauer @DavidBSauer]

Step-by-step protocol to make stable cell lines for large-scale expression of muscle-type nAChR (and other multi-subunit targets)!

By the inexhaustible and tenacious @Anna_Liiiiiiii
in collab of @CMS_CDG_Oxford in @MRC_WIMM and @CmdOxford

https://t.co/m65bzG4tA5

[David B Sauer @DavidBSauer]

New publication for SLC13A5 targeting compounds! Discovery of the BI chemical probe is out now in J. Med. Chem.

Great work by Andrew Quigley, Liz Carpenter, and colleagues from Oxford's @CmdOxford, @Boehringer, and @thesgconline

https://t.co/G4mjvLxjZ0

[David B Sauer @DavidBSauer]

In another case of transporters doing more than you expect: SPNS2 is a glucose importer, in addition to its S1P export activity!

Wonderful collaboration with Sarah Spiegel and colleagues at VCU School of Medicine, and the team at @CmdOxford

https://t.co/93zv8okFPR

[David B Sauer @DavidBSauer]

Our study of the CAT1 amino acid transporter and viral receptor is now online in @NatureComms!

Led by the incredibly talented @mingda_ye, with colleagues from @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, @NDMOxford, and supported by @im2pact_project

https://t.co/EJQC2whR8m

[Ruben Gonzalez @rubenlgonzalez]

New work out today in PNAS!

Secondary active transporters are everywhere, but direct observation of their structural dynamics is rarely achieved.

Here, we capture the real-time dynamics of a sodium-coupled dicarboxylate transporter using smFRET.

🧵⬇️
https://t.co/7GtEr4IdKC

[Anna Li @Anna_Liiiiiiii]

Thrilled to submit another paper with Yin Yao Dong @CMS_CDG_Oxford and @DavidBSauer 🥳🥳🥳 ✍🏻✍🏻✍🏻🦠🦠🦠 (📸photo credit: Claudia Burn-Leefe)

[Mingda Ye @mingda_ye]

Gluebodies for improved crystal reliability and alternative crystal forms! (also inspiring Di-Gembody for cryoEM) @CmdOxford @FrankvonDelft Now out in ACS Central Science @ACSCentSci
Many thank to great supporters! @RosFrankInst @OxfordStrubi @DavidBSauer

https://t.co/7i1gzQS5mG

[David B Sauer @DavidBSauer]

Closing soon!

Please apply if you are interested in targeting membrane proteins with new therapeutics!

[David B Sauer @DavidBSauer]

Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!!

Happy to chat about any questions about the role and science.

Oxford will assist with a skilled worker visa.

Please RT!

https://t.co/NPjNkDJ7wU

[David B Sauer @DavidBSauer]

Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!!

Happy to chat about any questions about the role and science.

Oxford will assist with a skilled worker visa.

Please RT!

https://t.co/NPjNkDJ7wU

[David B Sauer @DavidBSauer]

I'm far more active on the Bluesky platform, if you want to find me there

https://t.co/CruHUNn2s3

[David B Sauer @DavidBSauer]

Ugh. In case it wasn't obvious, this account was recently hacked. (Hopefully) now resolved

[Martin Walsh OBE @MartinWalshDLS]

First keynote of the day from ⁦@DavidBSauer⁩ #bcium2025 …before coffee and chocolates from ⁦@DECTRIS_News⁩ ⁦@ccp_em⁩ ⁦@ccp4_mx⁩ ⁦@instructhub⁩

[David B Sauer @DavidBSauer]

New plan: already delayed flights have no further hiccups AND fast passport control.

Trying to be hopeful 😬

Gratitude to @VirginAtlantic customer serv. for coming up with a plan

[David B Sauer @DavidBSauer]

Another year, another mess with canceled flights. 🤬

@VirginAtlantic - Flight canceled txt, but we'll automatically rebook you.
- (I called after silence) We subcontracted the flight; you must sort out with @Delta

[David B Sauer @DavidBSauer]

Should I start taking boats??

[David B Sauer @DavidBSauer]

Cheeky visit to @unisabana during a family trip! Spectacular campus in the Colombian Andes

Thank you @NuryOlaya2 for a great discussion and showing us around!!

[David B Sauer @DavidBSauer]

I should add one great sadness of last year, losing our colleague @sagaraturi

An energetic and passionate scientist gone too soon

[David B Sauer @DavidBSauer]

Just finished our "State of the Group" talk in lab meeting

2024 Recap
- 9 papers published
- 6 papers in review
- 2 DPhils

What's next
- More papers in flight, landing soon
- Expand our toolbox and biomed relevance

Another year of great pride in our team!

[David B Sauer @DavidBSauer]

Two highlights of 2024 contained in one photo 😀

Titled "First CNS submission of a newborn (aged 4 days)"

Alternative title "Type VERY quietly!"

[David B Sauer @DavidBSauer]

And a parallel study on human muscle-type AChR by @RyanHibbs10 and colleagues!!

Wonderful to see that we agree on many points, while also making distinct and novel discoveries on AChRs in myasthenia gravis

https://t.co/SfRBn3ZzMC

[David B Sauer @DavidBSauer]

Now online! @Anna_Liiiiiiii fantastic work on the structure of the Human adult Muscle-type nicotinic receptor.

Wonderful collab with @CMS_CDG_Oxford at the @MRC_WIMM and @CmdOxford

https://t.co/WqfsQsj7y8