Mingda Ye

Solute Carriers, Structural Biology

[David B Sauer @DavidBSauer]

Our study of the CAT1 amino acid transporter and viral receptor is now online in @NatureComms!

Led by the incredibly talented @mingda_ye, with colleagues from @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, @NDMOxford, and supported by @im2pact_project

https://t.co/EJQC2whR8m

[Mingda Ye @mingda_ye]

Gluebodies for improved crystal reliability and alternative crystal forms! (also inspiring Di-Gembody for cryoEM) @CmdOxford @FrankvonDelft Now out in ACS Central Science @ACSCentSci
Many thank to great supporters! @RosFrankInst @OxfordStrubi @DavidBSauer

https://t.co/7i1gzQS5mG

[David B Sauer @DavidBSauer]

Very successful (and fun) group picnic. Thankfully the very English weather was accommodating!

Thank you @GL_Isom for joining!

[David B Sauer @DavidBSauer]

Mingda's work resolves major details of CAT1 function
- Selectivity and transport for amino acids Arg, Lys, Orn
- Friend Murine Leukemia virus binding to MmCAT1 with nM affinity yet having narrow host tropism

[David B Sauer @DavidBSauer]

Cationic amino acid transport and viral binding of MmCAT1

Fantastic work by @mingda_ye and colleagues at @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, and the @im2pact_project

https://t.co/5Lw4xZBd9G

[David B Sauer @DavidBSauer]

New paper submission by the incredibly talented @mingda_ye and colleagues at @CmdOxford @OxfordStrubi @CAMS_COI_Ox

Preprint coming soon!

[OMass Therapeutics @omasstx]

Our Director of Protein Biochemistry & Structural Biology @katharina_duerr will be presenting at Gordon Research Conferences’ ‘New Insights into Structure, Function, and Regulation of Critical Membrane Transport Proteins in Health and Disease’ conference.

https://t.co/AcKo2C1JfU

[Ellen Zhong @ZhongingAlong]

CryoDRGN-ET❄️🐉 is published in @naturemethods! We combine neural fields and generative modeling to reveal the structural heterogeneity of protein complexes *in situ*! So excited to see this out, and huge congrats to @ramyarangan, @FeathersRyan and team!

https://t.co/4l8G2D315h

[Simon Newstead @inwardopen]

Really excited to be here at the 2024 structural biology meeting at Tsinghua University, with Prof Yigong Shi kicking off the meeting.

[Nuffield Department of Medicine @NDMOxford]

Congratulations to Prof Peijun Zhang from NDM's Division of Structural Biology and @DiamondLightSou for being elected to @EMBO membership 👏🎉

Find out more 👉 https://t.co/b02PkiWgld

[Medical Sciences @OxfordMedSci]

Collaboration in Action: Academic-Industry Stories

In his story, Benedikt Kessler @NDMOxford shares how collaborating with industry has driven breakthroughs in ubiquitin biology research. #CollaborationInAction

Read Benedikt’s story: https://t.co/IzBxpi2Qu0

[David B Sauer @DavidBSauer]

David and I wrote a quick Preview for @Structure_CP to provide some context around the fantastic recent Pho90 work by @Oezkan_YildizZ and colleagues!

https://t.co/jrSzZeeVXJ

[David B Sauer @DavidBSauer]

And it's out!

Structure and function of the proline transporter SIT1 in complex with ACE2

Congrats to Huanyu, Ashley, Irina, @robertvandenbe2, Liz Carpenter, @T_dafforn, and the many other collaborators from @CmdOxford, @uobbiosciences, @Sydney_Uni

https://t.co/JkxTdmCxP6

[Mingda Ye @mingda_ye]

@DavidBSauer Congrats!

[David B Sauer @DavidBSauer]

Dimerize nanobodies to duplex data collection AND determine structures of small targets!

https://t.co/R2Ybnv2JT2

[Katharina L. Duerr @katharina_duerr]

@DavidBSauer @GroupZhang @FrankvonDelft @CarriqueLoic @EmmitLi @OxfordStrubi @PharmOxford @DiamondLightSou @eBIC_Diamond @CmdOxford Very cool new strategy for solving small proteins by cryo-EM! Testing different hetero/homoDi-Gluebodies may also help against problems with prefered orientation. Congrats! Here is the sister preprint about Gluebodies for enhanced crystal reliability: https://t.co/qC37orVaOs

[David B Sauer @DavidBSauer]

A wonderful collaboration of @GroupZhang, @FrankvonDelft, @katharina_duerr, @CarriqueLoic, @EmmitLi, @OxfordStrubi, @PharmOxford, @DiamondLightSou, @eBIC_Diamond, and @CmdOxford