davidkdryan

Doctor interested in big data + drug development | @NIHRresearch ACF and ST3 Clinical Pharmacology & Therapeutics @UCL | @LSHTM Med Stats | He/Him 🇮🇪 🏳️‍🌈

[davidkdryan @davidkdryan]

Thanks to a great team of supervisors: @Anoopshah4, @pbidulka, @RuthHKeogh, Elizabeth Williamson, @tomlumbers, Karla Diaz-Ordaz.

8/8

[davidkdryan @davidkdryan]

Delighted to share the first output from my @NIHRresearch PhD @UCL_IHI

We conducted a trial emulation using UK primary care data to examine the real-world effectiveness of SGLT2 inhibitors in #type2diabetes

Here is a brief 🧵: 1/8

https://t.co/i92gPomNfS

[davidkdryan @davidkdryan]

⚖️ The priority now: equitable access

There are disparities in prescribing of SGLT2i - particularly affecting women and people from minority ethnic backgrounds.

Real-world evidence can inform guidelines.
But equitable implementation improves outcomes.

7/8

[davidkdryan @davidkdryan]

Manifesting balanced covariates today as I try to finish my #medstats MSc dissertation @LSHTM #pharmacoepi #healthdatascience 🙏

[davidkdryan @davidkdryan]

@rab4__ It's Me! Hi. I'm the problem it's me?

[Amy Yu, MD @amyyu_md]

UK pharmacovigilence study:
✅️ Apixaban has the safest profile for GI bleed compared to all other DOAC
✅️ More GI bleeds in women vs men, especially with Dabigatran
❎️ No data on dosage, antiplatelet use, history of GI bleed
Presented by @davidkdryan #ESOC2024

[davidkdryan @davidkdryan]

Great collaborating with Prof Bunker @HealthySkin4All @uclh - looking at signals for SJS/TEN associated with ibuprofen. ⚠️High signal for association in spontaneous drug reports 🟨 but could be 🔁reverse causality or 🔀co-causality #dermatology #pharmacovigilance #pharmacoepi

[medRxiv @medrxivpreprint]

Association between Stevens-Johnson syndrome and toxic epidermal necrolysis with ibuprofen: A pharmacovigilance study in the UK Yellow Card scheme and systematic review of case reports https://t.co/OfxkArcfSY #medRxiv

[davidkdryan @davidkdryan]

Very excited to be leading the first practical of the 'Genetics in Drug Development' course @MRC_BSU @Cambridge_Uni 🧬💊Today we will be covering examples including IL-6⃣inhibitors and drugs in #AlzheimersDisease 🧠@dpsg108 @stevesphd @karhunen_v @htcronje https://t.co/x2Vd9TJeyR

[davidkdryan @davidkdryan]

Great day spent learning health economics 📈 and inclusive #clinicaltrials 💊 with @BritPharmSoc #lego #markov #clinicalpharmacology

[davidkdryan @davidkdryan]

Superb work being done by @pearsekeane and team @Moorfields

An #opensource foundational model, trained on retinal images, that can identify both eye and systemic diseases. 👁️❤️🧠

As a general medic, this is fascinating! Will the retina be a key part of future diagnostics?

[Pearse Keane @pearsekeane]

1/

🚨🚨 New paper alert 🚨🚨

Introducing RETFound, a foundation model for ophthalmology

We’re super excited about this and hope it will act as a #Cornerstone for global efforts to prevent blindness through #AI

@UCLeye @Moorfields

#OpenAccess @Nature
https://t.co/DsvKgeUH5m

[davidkdryan @davidkdryan]

@DrBenLovell Favourite city in the world! 🗽 Museums: the met, MoMA, the frick collection. Bars: Marie's crisis cafe (a must!), le bain (sunday evening is best). Random: high line, DUMBO, river boat, smorgasburg, Roosevelt Island tramway. Restaurants: Red rooster Harlem, Jack's wife Freda

[davidkdryan @davidkdryan]

Looking forward to swapping Neave's statistical tables for @PioneerDJglobal's table this weekend following my @LSHTM #medstats exams this week. Glad to have some degree of freedom for a while 🎧☀️⛱

[davidkdryan @davidkdryan]

#Pharmacovigliance study using the @MHRAgovuk yellow card scheme to study the association between ibuprofen and SJS-TEN for #EADVCongress. Thanks to Prof Bunker @uclh for supervising! #clinicalpharmacology #dermatology #datascience. Code notebooks: https://t.co/cTEfnW2jtN

[davidkdryan @davidkdryan]

*hot off the press* - great working with Professor Banerjee (@debukidney) and Dr Fadi Jouhra on this review article. #heartfailure #nephrology #cardiology #clinicalpharmacology

Management of HF in Patients with CKD | ECR Journal https://t.co/P2YCPukjt8

[davidkdryan @davidkdryan]

Sunrise this morning from the top of @uclh - a nice way to ring in my 27th year orbiting the sun. #goodmorning #london #sunrise #skyline #doctor #nightshift https://t.co/twZlGNSHjK