David Wallon

[Gaël Nicolas @GJRNicolas]

Interested in working on human genome data from @PacBio's technology? Interested in the genetics of Alzheimer's disease? Skilled in bioinformatics? Apply for a #PhDposition in a dynamic, multidisciplinary team at the forefront of #Alzheimer's disease #genomics research!

[David Wallon @davidwallon_]

Le #CNRMAJ n'hésite pas en effet à se déplacer pour expliquer le plus simplement possible comment se diagnostique la maladie, quelles sont les lésions et quelles avancées thérapeutiques sont attendues.@franceinfo https://t.co/HJYYOfia2f

[David Wallon @davidwallon_]

Cette semaine passée, riche d'un congrès sur la maladie d'Alzheimer à Bordeaux #RFMASA, a aussi été l'occasion lors de la journée mondiale Alzheimer, de parler sur des plateaux radio et TV comme par exemple le magazine de la santé !
https://t.co/XnkZQCfc9a
@CHURouen @francetv

[Gaël Nicolas @GJRNicolas]

La journée mondiale contre la maladie d’Alzheimer avait lieu hier. @f3normandie s’est intéressé aux malades jeunes et aux aspects génétiques en visitant le Centre National de Référence Malades Alzheimer Jeunes (CNRMAJ) du @CHURouen @univrouen
https://t.co/XYhkoHywnf

[Mathias Jucker @MathiasJucker]

We were asked to summarize our thoughts on the recent Aβ-immunotherapy trials and what the next steps need to be - I am curious what you think? https://t.co/skN4E4VSHN

[David Wallon @davidwallon_]

@GarnierCrussard @VincentPlanche Merci @GarnierCrussard. Tout ceci ne pouvait pas être tranché mais la approche ont été très complémentaire !
Je repiquerai une image montrée dans ce congrès qui illustre un peu le propos...

[Céline Louapre @clouapre]

@SFNeurologie @EANeurology @ANAINFrance @LFCE_Epilepsie @SOFMA_fr @FondationARSEP @la_SFNV @Inst_Myologie Félicitations Marie pour ce prix prestigieux!!! Quelle belle représentation pour la neurologie française à l’#EAN2023

[David Wallon @davidwallon_]

@GJRNicolas @CharbonnierCam Congrats @CharbonnierCam !

[Université de Caen Normandie @Universite_Caen]

#Recherche Objectif du projet CIRAANO, porté par l’équipe @Neuropresage de @ChetelatLab : mieux comprendre le cerveau humain grâce à des outils d’imagerie cérébrale de pointe @Cyceron14 pour améliorer la prise en charge des patients atteints de troubles de la mémoire.

[David Wallon @davidwallon_]

@GJRNicolas Thanks @GJRNicolas you were faster than me! But indeed, an extensive description of that rare cause of early onset AD with still an interesting phenotype heterogeneity to understand... (work in progress... ) #Alzheimer #Genetics

[Gaël Nicolas @GJRNicolas]

Wondering about the imaging and clinical phenotype of APP duplication carriers? Here is the description of the French series of 43 carriers + comparison to sporadic CAA patients
https://t.co/0KKKKVqnz1
#Alzheimers #stroke

[Nicolas Villain / Moved to LinkedIn & BlueSky @nvillain_alz]

1/5 I am delighted to share (Open Access) the 1st part of our meta-analysis/review on high-clearance anti-amyloid immunotherapies in #Alzheimers with @VincentPlanche and Prof Richard Levy, finally published in #RevueNeurologique👇🏻
https://t.co/PWOvhkvG3u

[Prof Cath Mummery @cathmummery]

Lilly’s Alzheimer’s drug donanemab succeeds in PhIII trial – 35% slowing of decline in those with intermediate tau levels on both iADRS and CDRSB. Really exciting news for our patients. Details will be shared at AAIC #alzheimers #diseasemodification https://t.co/CSPCtVAzYs

[Gaël Nicolas @GJRNicolas]

How can short read, long read whole genome sequencing and RNAseq help diagnose patients with rare diseases? Our experience from 5 trios
https://t.co/f6lvR1TCsC
Thank you to all collaborators and big congrats to @francois_leco who did a terrific job!
@CHURouen @InsermNordOuest

[Gaël Nicolas @GJRNicolas]

Should SORL1 loss-of-function rare variants be used in genetic counseling of #Alzheimer disease as APP, PSEN1 or PSEN2? Some pieces of answer in our new paper published in @GenomeMedicine
https://t.co/aLkgCxs05s

[Gaël Nicolas @GJRNicolas]

And now Olivier Quenez from Rouen presenting the results of rare CNV association with Alzheimer disease in the ADES consortium #ADPD2022

[Edip Gurol @guroledip]

Congratulations @GJRNicolas @Kevin_Cassinari @GnBresearch @davidwallon_ et al. - "Increased copy number of APP is sufficient to cause AD and CAA, with likely earlier onset in case of triplication compared with duplication" @GreenJournal https://t.co/wyVLyuhfNL

[Gaël Nicolas @GJRNicolas]

Glad that the first APP triplication is reported by the lab where APP duplications where first reported back in 2006! Thank you to all coauthors @Kevin_Cassinari @GnBresearch @davidwallon_ and coauthors not on tweeter incl. Lou Grangeon, Anne Rovelet-Lecrux and collaborators

[Brain @Brain1878]

Grangeon et al. show that biallelic MYORG mutations cause primary brain calcification with cerebellar atrophy and a prominent motor phenotype. https://t.co/rJW1MMN7LB