Is Genicular Artery Embolization (GAE) the answer for the knee osteoarthritis treatment gap? 🦵🩸
We just published a comprehensive meta-analysis in @skeletaljournal, official journal of @intskeletal, pooling 18 studies (n=534).
Article 📰:
https://t.co/XW5SbSMAOl
A short 🧵 on our findings, heterogeneity, and the placebo effect:
Currently featured in @AAGLJMIG / @AAGL 🚨
We tackled one of the most delicate balancing acts in minimally invasive gynecology: excising endometriomas without compromising fertility.
Using a Bayesian Network Meta-Analysis (11 RCTs, n=956), we didn’t just pool the data, we probabilistically ranked the surgical options.
The SUCRA rankings revealed:
- Ovarian Reserve (AMH): Cystectomy with ultrasonic scalpel took the top spot.
- Pregnancy: Drainage with CO₂ laser vaporization ranked highest at 12 months.
- Caution: Cystectomy with suturing was the least favorable for preserving AMH.
Countless hours coding these Bayesian NMA in R definitely paid off to help map out this clinical roadmap. 🦅
Massive congratulations to co-first authors Katherine Miller, and @AnaPServidoni, under the exceptional guidance of Dr. Mauricio Abrao and the entire team!
🔗 Read the full featured paper here: https://t.co/naN7JB0nDN
@metaacademy_ofc
👇 For the endometriosis surgeons: how do these rankings shift your preoperative counseling?
#Endometriosis #MedX #OBGYN #MedTwitter #GynSurgery #EBM
Direct Aspiration (DA) or Stent Retriever (SR) for acute BAO? 🩸
The usual answer in the neuro-suite is "operator preference". But when you pool 1,851 patients across 14 studies, a clear safety gap emerges.
Here is the bottom line from our updated Meta-Analysis:
- DA takes the lead. It showed a significantly lower risk of symptomatic intracranial hemorrhage (sICH).
- A dead heat. No significant difference in 90-day functional outcomes or mortality.
This is the hard safety data you want in your back pocket when selecting your first-line device.
Massive kudos to Wei Jun Lee, MD (@Dylon_WJLee) for leading this effort!
🔗 Dive into the full paper in @ESNRad@NRADjournal: https://t.co/dNnWotEOph
@metaacademy_ofc
👇 Is DA your default go-to, or do you still reach for the SR first?
Let’s debate.
#MedX #NeuroTwitter #Stroke #NeuroIntervention
Massive thanks to my co-first author Lucas Habiro Alves, our senior mentors @atultanejamd and Dr. Bernard Giancristoforo, and the entire research team for their hard work and trust throughout this project.
@metaacademy_ofc
You can read the full paper in Skeletal Radiology here: 🔗 https://t.co/XW5SbSMAOl
Pinging 🚨 the IR and MSK communities: #IRad #MSKRad #EpiTwitter #MedTwitter #EvidenceBasedMedicine
Is Genicular Artery Embolization (GAE) the answer for the knee osteoarthritis treatment gap? 🦵🩸
We just published a comprehensive meta-analysis in @skeletaljournal, official journal of @intskeletal, pooling 18 studies (n=534).
Article 📰:
https://t.co/XW5SbSMAOl
A short 🧵 on our findings, heterogeneity, and the placebo effect:
So, where does GAE actually fit in our current algorithm? 🤔
Despite the uncertainties, it fills a very real clinical gap. For patients who have failed conservative management, but either aren't candidates for or want to defer a TKA, GAE offers a viable, minimally invasive bridge.
Moving forward, future trials must move beyond just treating pain. We need to focus on imaging-based inflammatory phenotyping and standardizing our embolic protocols to figure out exactly who benefits most.
Massive thanks to my co-first author Lucas Habiro Alves, our senior mentors @atultanejamd and @bernardgiancristoforo, and the entire research team for their hard work and trust throughout this project.
@metaacademy_ofc
You can read the full paper in Skeletal Radiology here: 🔗 https://t.co/XW5SbSMAOl
Pinging 🚨 the IR and MSK communities: #IRad #MSKRad #EpiTwitter #MedTwitter #EvidenceBasedMedicine
So, where does GAE actually fit in our current algorithm? 🤔
Despite the uncertainties, it fills a very real clinical gap. For patients who have failed conservative management (NSAIDs, intra-articular injections) but either aren't candidates for or want to defer a Total Knee Arthroplasty (TKA), GAE offers a viable, minimally invasive bridge.
Moving forward, future trials must move beyond just treating pain. We need to focus on imaging-based inflammatory phenotyping and standardizing our embolic protocols to figure out exactly who benefits most.
This past weekend, we had an incredible kick-off session with our Ambassadors for the 2025-2026 cycle.
We are honored to have you as part of the program leadership, and couldn’t be more excited to welcome so many new members.
📢 Previous and current ambassadors, let’s share your best memories so far and get them inspired below!