Dave Lawrence

Bioinformatics dad jokes

[Dave Lawrence @davmlaw]

@SallTheSmug Relish is pretty good for instant

[Dave Lawrence @davmlaw]

@andre_quentin Make a plan file, remove A from plan, clear context, implement plan.

[Dave Lawrence @davmlaw]

@jermdemo > the world needs a vibe coded VEP replacement

It's here! https://t.co/wEDCrJnY2p

[Dave Lawrence @davmlaw]

@jermdemo Because you only need to run it once per genome then can share a static file?

I agree the world needs a vibe coded VEP replacement... and the definitive open source LIMs

[Dave Lawrence @davmlaw]

Charlotte dies and the kids are sobbing. I pause to compose myself "She's gone kids, but not forgotten. The invasive experiments can finally begin"

[Dave Lawrence @davmlaw]

Reading to my kids and it's a standard sci-fi setup: humans discover a non-human intelligence that writes in symbolic language. First contact. biggest event in history.

Then it takes a bizarre turn where everyone just fixates on the pig it wrote about

[Dave Lawrence @davmlaw]

@pleometric This captures the moment so beautifully

[Dave Lawrence @davmlaw]

@Teknium I got blocked a few times. Change the prompts a bit and retry. Put things in a plan file and vaguely point towards the direction you want it to go

[Dave Lawrence @davmlaw]

@norvid_studies I didn't enjoy working on cars. Often it was really painful to get to anything (bad angles, had to take out other stuff to get to something) while bikes you can move easily, walk around and everything is just there

[Dave Lawrence @davmlaw]

@norvid_studies I haven't done work on a car other than battery/wipers for 15+ years.

I used to build my PCs from scratch / scavenged parts and was constantly upgrading.

In the last decade I have unscrewed my laptops once (to put in a new SSD)

[Dave Lawrence @davmlaw]

@freed_dfilan I have been writing more, higher ambition software

There are still many non accelarated bottlenecks like testing, patient recruitment, wetlab work and clinical validation.

Looking back over 2 years it will be obvious though

[Dave Lawrence @davmlaw]

@Silicon_alien A lot is too small to see. To examine the state of a living thing, you have to kill it, then do some chemistry to read a snapshot of a small part.

This is less than ideal when the whole point of life is that it's alive, and is made of many moving parts.

[Dave Lawrence @davmlaw]

@norvid_studies @medjedowo It would be interesting to dig into these stats. And compare titles vs sales vs hours played. Strategy game diversity is down but people are logging mega hours on Crusader kings and Factorio

[Dave Lawrence @davmlaw]

@norvid_studies @lion_tender @lefineder @cruelsardaukar Schelling zero point zero

[Dave Lawrence @davmlaw]

@i_zzzzzz Can't believe they deleted the scene where the alien with 6 hands reformatted 3 tariff pie charts at once

[Dave Lawrence @davmlaw]

@lion_tender @norvid_studies @lefineder @cruelsardaukar Almost all of human civilisation and culture is arbitrary. Still cool, though!

[Dave Lawrence @davmlaw]

@lion_tender @norvid_studies @lefineder @cruelsardaukar an "arbitrary human choice" is better than no choice. Picking a zero gave us global navigation, consistent maps, world trade, and standard time

[Dave Lawrence @davmlaw]

@sinabooeshaghi Can't wait for the RNAseq plots where they draw 20,000 dots by hand

[Dave Lawrence @davmlaw]

@norvid_studies Data from https://t.co/wvUUl9yBoo