Francesco Santoro

Associate professor in microbiology @unisiena. Interested in bacterial genetics, MGEs, sequencing technologies, transcriptomics of the immune response

[Francesco Santoro @debaser83]

@CrazyItalianPol

[Brad Spellberg @BradSpellberg]

for resistance to other FQs. It absolutely does.
HOWEVER, THIS DOES NOT MEAN THAT YOU SHOULD JUST USE CARBAPENEMS-LINEZOLID FOR EVERY PATIENT WHO WALKS THROUGH THE DOOR BECAUSE NOTHING MATTERS!
And here's where the messaging could have been more nuanced.

[Francesco Santoro @debaser83]

@DrToddLee @ABsteward Can you please elaborate more on that?

[Francesco Santoro @debaser83]

@DrToddLee @ABsteward Wow, didn't know about this...I'm sure it works in vitro. I believe clinicians in my hospital like mero/vab better, but I don't know if this is the reason.

[Francesco Santoro @debaser83]

@ABsteward @DrToddLee Yes, KPC was THE problem a few years ago

[Francesco Santoro @debaser83]

@ABsteward @DrToddLee Mainly against KPC producing enterobacterales

[Francesco Santoro @debaser83]

@DrToddLee @ABsteward Also does nothing on metallo beta lactamases, which are the most frequent in Pseudomonas. Imi/rel was not designed as an anti-pseudomonas drug.

[Francesco Santoro @debaser83]

@BradSpellberg @ZCiochettoMD424 Can static vs cidal be an issue in severely immunosuppressed patients (e.g. those under treatment for acute leukemia)?

[Francesco Santoro @debaser83]

@vivax74 @ABsteward According to EUCAST, Pseudomonas is always SDD (breakpoint for S is 0.001 if I remember correctly), which means therapy is always high dose, standard dose would be 12g/day.

[Francesco Santoro @debaser83]

@BoMiaoFinance @DeryaTR_ True, except that reviewers don't get paid

[Francesco Santoro @debaser83]

@florian_krammer @Elons_Rabbi This reminded me of Mr Burns and phrenology https://t.co/aR0k9ZYUwv

[Francesco Santoro @debaser83]

@OdedRechavi For a more recent album, I'd reccomend Big Swimmer by King Hannah

[Francesco Santoro @debaser83]

@OdedRechavi Nick Drake, my favorite is Pink Moon (only 28 mins) but Bryter Later and Five Leaves Left are wonderful as well

[Francesco Santoro @debaser83]

@vikkypaedia @MicrobiomDigest It seems they truly mastered machine learning

[Francesco Santoro @debaser83]

@Massimi77859073 @grande_flagello @The_Journalai Trasformati in carne e patate per ricordare le nostre radici carnivore

[Atin Sharma @atins88]

Any microbiologist out here who has been using Chatbots for their bioinformatics/computational needs? I want to know more about their experience.

Please RT for visibility! 🙂

[Francesco Santoro @debaser83]

@atins88 My group has used ChatGPT for building and improving a bioinformatic pipeline for the analysis of nanopore sequencing data of PCR amplicons

[Francesco Santoro @debaser83]

@NikoMcCarty @AsimovBio How can I order from Europe? Also, which encoding did you use for alphabet-->DNA translation?

[Francesco Santoro @debaser83]

@amirshanehsaz @abscibio The abstract on bioRxiv is a wrong one, make them correct it

[Tania Henríquez @Tania_H_A]

We are excited to share our latest publication on the utility of a commercial kit for the isolation of vesicles from clinical strains of Pseudomonas aeruginosa 🧫 #Pseudomonas #OMVs @JournalSpectrum https://t.co/66LnN4NSRY