DEBOJYOTI CHOWDHURY

In love with the fundamental forces of nature..

[DEBOJYOTI CHOWDHURY @DEBCHEM7]

@chatpatebatashe @worshipVK By your logic, if saying "we should kill our PM" is okay, then eve teasing is also freedom of speech and not a criminal offense...you idiots are so delusional and illogical.. You are A bunch of narcissistic dumbasses.. "None" has ever been arrested for merey criticizing this govt

[DEBOJYOTI CHOWDHURY @DEBCHEM7]

@aravind Also include a new rule that any protesters caught to destroy govt and public properties, should be barred from voting for 10 years... more than half of the vandalism will stop..
Also any student caught in vandalism should be rusticated from studies for 1 year atleast

[Shubhasis Haldar @HaldarShubhasis]

Our study on Single Molecules reveals something unexpected: Homologues chaperones can have completely different roles. We explain this surprise with strain theory, diving deeper into how proteins fold.
The paper published in protein science [IF: 8] https://t.co/Q7zt7lPaPB

[Elisabeth Bik @MicrobiomDigest]

ChatGPT generates fake data set to support scientific hypothesis
* Researchers say that the model behind the chatbot fabricated a convincing bogus database, but a forensic examination shows it doesn’t pass for authentic.
@MiryamNaddaf writes @Nature
https://t.co/7DILWQgshm

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[bioRxiv Cell Biology @biorxiv_cellbio]

Methotrexate-modulated talin-dynamics drives cellular mechanical phenotypes via YAP signalling https://t.co/KxZlTD4mof #biorxiv_cellbio

[DEBOJYOTI CHOWDHURY @DEBCHEM7]

@sama Come with your original ID Tony Stark! And why have you renamed Jarvis to #OpenAI #gptchat??
Hat's off.. Beyond Imagination!! Appreciation from India.

[DEBOJYOTI CHOWDHURY @DEBCHEM7]

@abhijit_MLab Sir, are they better than cultrex ECM, have you checked? they are made of ECM components and physiologically relevant. Actually I am looking for a matrix, on which brain organoids can be studied, in modifiable stiffness, and also should be physiologically relevant.

[DEBOJYOTI CHOWDHURY @DEBCHEM7]

@Jdinesh525 Congratulations

[DEBOJYOTI CHOWDHURY @DEBCHEM7]

@RitikaNara @Cambridge_Uni @GurdonInstitute @LupinCambridge Congratulations Ritika! Have a great research life ahead

[DEBOJYOTI CHOWDHURY @DEBCHEM7]

We have discussed the plausible mechanical aspects of integrin regulated autoimmune diseases. It's an important topic to understand autoimmunity properly. Hope this will help to build strategies against this global concern. Follow this link to read the full article.

[Frontiers - Cell Biology @FrontCellDevBio]

New Research: Integrin Regulated Autoimmune Disorders: Understanding the Role of Mechanical Force in Autoimmunity: The pathophysiology of autoimmune disorders is multifactorial, where immune cell migration, adhesion, and lymphocyte activation… https://t.co/f6WAAAGxak #celldevbio