Delgoffe Lab

Cancer Immunometabolism - Professor - Director: Tumor Microenvironment Center - @PittTweet @UPMCHillmanCC - CoFounder:Novasenta - EiC:Immunology - views my own

[Delgoffe Lab @DelgoffeLab]

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ https://t.co/zACqCLxDMU

[Leonidas Platanias, MD @LeonidasPlatan1]

One can only imagine how many of this we would have if the NIH budget were to be doubled or tripled. And how many more lives-would be saved. Something totally doable.

[Delgoffe Lab @DelgoffeLab]

Amazing work from the @airdlab showing the importance of aKG for histone acetylation, rather than its more canonical role as a TCA cycle intermediate and cofactor for demethylation reactions! Kudos to all the authors!

[Katherine Aird @airdlab]

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats @ApoorvaUboveja!
https://t.co/o4ekqG9E4Y

[Pitt Department of Immunology @pitt_immunology]

"An army marches on its stomach" is true of the immune system, says @DelgoffeLab on @CBCQuirks, speaking about his and @DrAlok_np40's new @Nature study that found a single meal primes T cells to better fight infection and respond to cancer immunotherapy. https://t.co/R3Va69GsvR

[Max Marchione @maxmarchione]

Retatrutide phase 3 obesity trial just came out and the results are genuinely insane:

- 28.3% bodyweight lost on 12mg over 80 weeks
- 70.3 pounds on avg. or 31.9 kg
- 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory)
- 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients
- 65.3% of 12mg patients dropped below the obesity BMI threshold
- 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%)
- significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP
- no cardiac or liver signals

Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.

[The Mark Foundation for Cancer Research @TheMarkFdn]

Love seeing our grantees in action! 🔬

This week, @Becky_ABC caught up with Greg Delgoffe & Tullia Bruno at the University of Pittsburgh, chatted with early-career researchers, and toured Pitt’s new biomed research hub.

Thanks for the great visit, @UPMCHillmanCC @PittTweet!

[Immunology Podcast @ImmunoPodcast]

In this @nature study, researchers in the @DelgoffeLab at @PittTweet showed that the short-term nutritional state of an individual has marked effects on T cell #immunity. 🍎

Read more: https://t.co/ENMtTX4QLs
Tune into the discussion: https://t.co/1fy2o6O35h

[Delgoffe Lab @DelgoffeLab]

As you may know, every year @OveracreLab and I ride tandem to raise money for cancer research at @UPMCHillmanCC. Imagine the power if all my followers even donated a few bucks! 100% of your deductible donation goes straight to research!

https://t.co/CpjkvnoeOi via @R2C_Cancer

[Delgoffe Lab @DelgoffeLab]

So honored and excited to talk about our new study, published in @Nature, on the BBC! @bbcworldservice

https://t.co/x8PG7CAY3C

[Biopatrika @biopatrika]

#researcherspotlight Dr. Alok Kumar @DrAlok_np40 from Prof. Greg M Delgoffe lab @DelgoffeLab at University of Pittsburgh @PittTweet talks about his work on "How Eating Affects Immunity: Post-Meal Lipids Boost T Cell Function and Cancer Therapy" @Nature https://t.co/pobiq7axKG

[HARD FACTOR @HardFactorNews]

They did the meme!!!

[Delgoffe Lab @DelgoffeLab]

@Kevin_McKernan Umm, he’s actually talking about the necessity of basic science. You don’t get innovations without doing the curiosity based discovery. That being said, the CSR and study sections are broken, but he’s arguing for MORE basic science!

[Delgoffe Lab @DelgoffeLab]

While we can't go wrong with either choice in the @sitcancer election, I want to highlight the leadership and vision of @RobertFerrisMD. A dedicated surgeon and cancer immunologist, Bob's contributions to the field are immense; we'd be lucky to have him at the helm of SITC.

[Robert Ferris, MD, PhD @RobertFerrisMD]

Thank you @sitcancer for the opportunity to participate in this election process, and to help contribute to the future of this amazing society! @UNC_Lineberger

[Delgoffe Lab @DelgoffeLab]

Thanks to @smithsonianmag for highlighting our work in @Nature about postprandial control of immunity! https://t.co/ZaTNflJnh5

[Delgoffe Lab @DelgoffeLab]

@SantoshVardhana This is important; bravo for bringing it up. I don't understand where the vitriol comes from (like "who hurt you, dude?"). I tend to review papers, even if I don't agree, as a summary of a lot of work; if they respond to critiques with even more, then it's good enough for me.

[nature @Nature]

Nature research paper: Postprandial lipid metabolism durably enhances T cell immunity

https://t.co/myej0mZSzk

[Delgoffe Lab @DelgoffeLab]

@MagarianBlander @Nature @CellCellPress Thank you!

[Delgoffe Lab @DelgoffeLab]

The world is full of odd happenstances. On the same day our paper on postprandial metabolism dropped @Nature, my 1st grad student, Nicole, published her postdoc paper at @CellCellPress! An incredible tour de force studying proteostasis in T cell exhaustion https://t.co/UdbPIQZY2h

[Delgoffe Lab @DelgoffeLab]

@RoychoudhuriLab Thanks! So, we thought this. And, if after all of the murkiness of that RCT is worked out and it ends up being solidly true, we think this could be a mechanism!

[Kiran Mazumdar-Shaw @kiranshaw]

Can diet shape immunity? At University of Pittsburgh, Greg Delgoffe and team show T cells respond better after meals, likely boosted by higher protein production for faster activation. The experiment may pave way for better CAR T-cell therapy as engineered T-cells fight much effectively. https://t.co/df9HlrHar4