Here’s a list of HAE prophylactic revenue from 2024:
$TAK $BCRX $NTLA $PHVS $IONS
Takeda (Takhzyro) 💉 ~$1.5 billion
BioCryst (Orladeyo) 💊 $437.7 million
CSL Behring (Haegarda) 💉 $400m+
Takeda/CSL (Cinryze) 💉 ~$100m
Coming:
CSL Behring again (Garadacimab) 💉
• approved in UK (Jan 25’)
• approved in Japan (Feb 25’)
• EU expected in Q1 25’
• FDA PDUFA was set for Oct 24’ but I couldn’t find any word on the delay
Ionis (Donidalorsen) 💉
• Aug. 21, 2025 PDUFA
Pharvaris (Deucrictibant) 💊
• started phase 3
• likely approved around same time as NTLA
Intellia (NTLA-2002) one and done ✅
• started Ph. 3, BLA 26’
This image by Nigerian illustrator Chidiebere Ibe of a Black fetus in the womb went viral. Still a medical student, Ibe will now have some of his illustrations published in a clinical handbook.
Chidiebere Sunday Ibe is a Nigerian medical student at Copperbelt University in Zambia and the lead medical illustrator of the International Center for Genetic Disease at Brigham and Women's Hospital, Harvard Medical School. Ibe is from Ebonyi State in Nigeria.
Having lost his mother to surgery for fibroid, he became passionate about medicine, especially as it relates to mothers and children. He is a self-taught medical illustrator. He learnt to draw medical illustrations using just a computer mouse. He is aspiring to be a pediatric neurosurgeon.
Okay let's do Nano today!
Let's break down the three major crypto token roles (gas, investment, product) as they apply to Nano, and explore why it would make sense to buy the token. Here we go:
🪙GAS TOKEN: Nano (or N/A)
Nano is a feeless system, so technically speaking, there is no gas token. Practically speaking, however, Nano has a bucketing system for ordering transaction priority. Individual accounts can do a certain number of transactions in a given timeframe, but also certain balance categories (i.e. 1-10 XNO, 10-100, etc.). This is to ensure no one games the system to spam at others' expense.
While this is designed to fully democratize access to the network, it's undeniable that having more Nano gives you more options for various account balances, and therefore more capacity during congestion periods. In this way Nano does act as a gas token at high scale.
You would buy Nano as a gas token if you have high-volume payment needs and want to make sure your transactions will always go through quickly, even in times of very high congestion.
🪙INVESTMENT TOKEN: N/A
There really is no investment token. If Nano does really well and starts processing billions of transactions, there's no direct correlation to the price of the token.
You should only buy Nano as an investment if you anticipate shortages and high demand for it as a gas or product token. But really, you shouldn't buy Nano as an investment, unless it's purely speculative.
Again, this is by design.
🪙PRODUCT TOKEN: Nano
Even more than in virtually every other cryptocurrency (because of strict data limits in transactions), you can do just one thing with Nano: send Nano.
You should buy Nano as a product token if you want to hold and send Nano.
This is all by design!
Nano's not really a good investment, but it was explicitly designed that way. At all levels, every aspect of its design was engineered to make it the opposite of an investment, to make it hard to make money out of the system.
I rant about "stop hoarding gas tokens" a lot, but with Nano it's even more acute. Plain and simple, in almost any case other than the shortages I described above, you should not invest in Nano. Period.
I predict some people will get mad at me for saying this, because they very well did buy Nano as an investment. They really shouldn't have. I repeat again: everything about its design was created to make it an anti-investment.
The Nano community should be perfectly happy if the token price stays exactly the same as it is today, for all eternity.
Businesses are Nano's "investment token"
If you want to profit off of Nano's success, build a business. Build a wallet or service that charges a fee in times of high congestion for priority transactions. Build a remittance business. Start an exchange. And so on.
I repeat myself, but Nano was designed to remove all direct profit incentives from the protocol itself. If you want a return on investment, do a business that makes money in part because of its ability to use Nano's network and capabilities.
This is true with all cryptocurrencies, and as I've pointed out before, the richest people in crypto are exchange founders. But with Nano it's even more focused in this direction.
In general, I don't think Nano will achieve a lot of business use cases, purely because of how (intentionally!) limited it is: you can't send any other data, you can't program it, you can't use it privately, and so on. It just sends the token.
But Nano does work really well at what it was designed to do. As long as there's people who want to send and receive an instant crypto for free, it has its place.
The markets are COOKED so @srpeters & I want to give back to all of you
2k in $ETH split between four people
To enter:
- RT this tweet
- Follow @JakeGagain & @srpeters on X
- Tag two friends in the comments below
Winners selected in 24 hours. Good luck.
💨 It’s FART DAY! 💨
Let’s celebrate with a $5000 @FartCoinOfSOL prize pool!
🎯 How to enter?
🔁 Retweet & like
👀 Follow @Solflare_wallet & @FartCoinOfSOL
💬 Share your most embarrassing fart story
🏆 2 winners (Top liked & our pick)
Let’s make some noise… or gas 😏👇
⚡ $1000 Giveaway ⚡
To celebrate the Shock's Early Access Beta on Feb. 5 at 20:00 GMT, we're dropping 💰
How to enter:
✔ Follow us
✔ Like & share
✔ Tag a friend
10 winners get $100 each!
Winners notified on Feb 6, 2025. Prizes credited to Shock balance after beta launch.
Democrats FREAK OUT & Attempt To Shut Down DOGE Audits At The US Treasury Department, Call For Fighting In The Streets
WH Press Secretary Karoline Leavitt Reminds Them That The American People Voted For Accountability Of Their Tax Dollars
» X LIVE:
https://t.co/ZkGQN1pZCB