Derda Lab

Genetically-encoded discovery are the heart of Derda Lab. A diverse and dynamic group located at UAlberta working on #phage #peptides & #glycans

[Ratmir Derda @RatmirDerda]

To distract everyone from the devastating NIH news, I recommend reading this Mirror Image Life discussion in Science magazine https://t.co/d3fE2tthux or popular press https://t.co/eEasWsa0OT and our view on this topic: TLDR: do not forget about Glycans! https://t.co/OnINCCkJlW

[Cell Chemical Biology @CellChemBiol]

The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage by Guilherme Meira Lima, @RatmirDerda @derda_lab, et al. at @UAlberta @StanfordUChem @usponline https://t.co/VrLnraMuBf

[Guilherme Meira Lima @Guilher63551077]

Excited to share our latest work on DNA-encoded liquid lectin array! This work would not have been possible without the amazing support and contributions of my colleagues at the University of Alberta!

[Cell Chemical Biology @CellChemBiol]

Online now! The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage by Guilherme Meira Lima, @RatmirDerda @derda_lab, et al. at @UAlberta @StanfordUChem @usponline https://t.co/HF8NqpPWc1 #chembiol

[GlycoNet @glyconet_nce]

Congrats to all the GlycoNet researchers on their paper about the liquid lectin array (LiLA), which uses DNA-encoded #lectins to detect subtle glycocalyx differences and enhance our understanding of #glycan composition.

@derda_lab @MatthewMacaule4 @glycocode @miratsojitra

[Ratmir Derda @RatmirDerda]

@CellChemBiol publication of Liquid Lectin Array (LiLA) led by Guilherme Meira Lima (https://t.co/PByIXNxccX) PhD Student from @derda_lab and co-authors from @MatthewMacaule4 Lab, @glycocode (Lara Mahal), Raymond Lai et al, now in https://t.co/M8WP5gPB3Z

[Mirat Sojitra @miratsojitra]

The Liquid Lectin Array (LiLA) paper is out in @CellChemBiol. Congratulations to @Guilher63551077 for this amazing publication and it was my privilege to play a [small] part in this project. #Siglec #Glycotime #Phage #Glycans
https://t.co/USVSqh0R9V

[Nature Protocols @NatureProtocols]

#FeaturedProtocol this week: #Liquidglycanarray (LiGA) platform to profile #glycan-lectin interactions on the surface of live cells https://t.co/rH6vmk4lRX #Glycotime #Siglec

[GlycoNet @glyconet_nce]

Congrats to the GlycoNet team on this important research that advances our understanding of how glycans interact with proteins on live cells using the LiGA platform!

@miratsojitra @RatmirDerda @MatthewMacaule4 @ednschmidt @Guilher63551077

[Mirat Sojitra @miratsojitra]

A big thank you to @RatmirDerda and @MatthewMacaule4 for their mentorship! This wouldn't have reached the finish line without a lot of help from @Guilher63551077 @ednschmidt, Kelli (Macauley lab) and all past and presents members of @derda_lab

[Ratmir Derda @RatmirDerda]

DNA-encoded, Liquid Glycan Array (LiGA) and its application to cell-surface profiling is out in @NatureProtocols . Big thanks to @miratsojitra for leading the effort and @MatthewMacaule4 + members of Macaluley Lab and @derda_lab ! https://t.co/x4XkZZHIbg

[Ratmir Derda @RatmirDerda]

I'm curious about any feedback from #Glycobiology #glycan #carbohydrate #glycotime community on @derda_lab preprint on DNA-encoded liquid #lectin arrays (LiLA). [LiLA] non-lineary amplifies detection of compositional differences of the cellular #glycocalyx https://t.co/O1kAGlHjqV

[Derda Lab @derda_lab]

@S_Schetters @miratsojitra @ednschmidt @Guilher63551077 @MatthewMacaule4 @RatmirDerda @bart @S_Schetters We focused on Siglecs in this pre-print, but it would be cool to see how LiGA can be applied to Galectins. Let's talk offline about it further?

[Derda Lab @derda_lab]

Delighted to share the pre-print of a LiGA protocol with detailed instructions to profile the glycan binding preference of cell surface #Siglecs using #ngs #glycotime

Shout out to @miratsojitra @ednschmidt @Guilher63551077 @MatthewMacaule4 @RatmirDerda

https://t.co/1Oxd1HmP4F

[Derda Lab @derda_lab]

This protocol follows previous publication from our lab describing ways to synthesize LiGA using synthetic glycans (https://t.co/9H9HZo4gGP) or direct chemoenzymatic synthesis of N-glycans on phage (https://t.co/6llFdySoLN)

Check it out!

[Derda Lab @derda_lab]

Exciting news from @tracy6528! 🎉 Check out her latest paper on 'Chemoenzymatic synthesis of genetically-encoded multivalent liquid N-glycan arrays' available online now. 📚🔬 https://t.co/tzTTVadAja

[Duong Bui @Duong_T_Bui]

Congratulations to our friend @miratsojitra who is now officially Dr. Sojitra. We are so proud of you. People will talk about how great you are as a scientist but we (Ann and me) will always remember you as our great friend.

[Peter Seeberger @peterseeberger]

Here we show that peptide-glycan chimera can be made on the same instrument on solid support. Next, an instrument to make #glycopeptides for #glycotime studies will be revealed.

[Derda Lab @derda_lab]

Today is the last day of our intern Allison. It's so nice to have you in our group for the past 4 months. All the best to your future adventures!

[Mike Downey @MichaelDowney10]

Really proud to have worked with this guy and to have watched him grow both as a scientist and as a human being over his undergrad career. Congrats, @ryannqiu! :)