Todd L. Lowary

A group of chemists interested in the role of carbohydrates in (microbial)
disease @IBCSinica.

Opinions are my own.

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Peter Chi
This study shows that #DNA #helicase #HELQ works with BCDX2 to promote #replication fork reversal. https://t.co/duKaREJhSx

#biochemistry #biochem #BRCA2 #FANCD2

[IBC Academia Sinica @IBCSinica]

Publication - by Dr. Peter Chi and Hsin-Yung Yen @ACSPublications
#Helicase-like #transcription factor (HLTF) involves in #DNA replication fork reversal. This study reveals the ATP-induced dimerization of HLTF and its role in DNA unwinding activity. https://t.co/z6qP2OI0Qj

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Chiaolong Hsiao @SciReports
A conserved radial distribution of #RNA A-#helices that characterizes the spatial structure of large #ribosomal subunits, providing a general ribosomal structure across evolutionary diversity. https://t.co/0XaG6C2kR6
#ribosome

[IBC Academia Sinica @IBCSinica]

🔬Publication - by @khooAS @ElsevierConnect
#ST3GAL3 knockout significantly reduced #viral association, uptake, and transduction of #VSV, suggesting ST3GAL3-dependent #sialylation of LDLR N-#glycans is required for efficient viral entry. https://t.co/fyseNzIlJF
#glycosylation

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Hsiao-Ching Lin
Selective #serotonin reuptake inhibitors may induce #MDR in gut #microbiota and #antidepressant #tachyphylaxis, offering new insights for novel central nervous system-targeted #therapies. https://t.co/aefIu7SO8A
#biochemistry #biochem

[IBC Academia Sinica @IBCSinica]

🔬Publication - by @asibc512 @ACSPublications
The mass photometry data demonstrated the diverse binding #stoichiometry across #SARSCoV2 #Omicron #subvariants, indicating that #S_protein mutations modulate #ACE2 engagement beyond mere affinity. https://t.co/N13n2Ts6XA
#biochem

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Yuan-Chih Chang @npjAMR
Cationic #peptide TP2-5, a ow-dose #antibiotic #adjuvant, showed envelope perturbation characterized by inner-membrane hyperpolarization, thereby enhancing antibiotic susceptibility of MDR E. coli. https://t.co/wE2e15swr7
#biochem

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Steven Lin @NatureComms
The newly established #genome-wide #CRISPR screening platform identified key regulators of #NK #cell functions, suggesting potential engineering targets for more potent NK #cancer #immunotherapy. https://t.co/Rl9yVCWiIm
#biochem

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Wei Yuan Yang and Guang-Chao Chen @CellPressNews
This study suggests that #lysosomes can sense the magnitude of #autophagy loads and quantitatively translate this signal into TFEB activation. https://t.co/EV7tRYWck2
#biochemistry #biochem

[Guang-Chao Chen @gcchen12]

Graded activation of the CLEAR network through mTORC1 suppression on c... https://t.co/a9LTql7Xti

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Meng-Ru Ho
By using #chimeric #Fab fragment cZ22-Fab, this study demonstrated the mechanism of #antibody-mediated Z-#DNA formation and stabilization, highlighting its potential for #autoimmune #disease treatment. https://t.co/ptMCqu6tDM
#biochemistry

[IBC Academia Sinica @IBCSinica]

2026 IBC summer #intern program applications are now open!
👉Application deadline: 2026/4/30
For more information, please visit: https://t.co/nf5mTMzinS

[IBC Academia Sinica @IBCSinica]

🔬Publication - by @Lowarylab @jbiolchem
#Kdo #transferase #KrkA from #Ecoli synthesizes K13 #capsule, and study of E. coli isolates suggests #polyphyletic origins for this capsular #serotype. https://t.co/yeUb0IaW9U

#biochemistry #lipopolysaccharide

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. MENG-CHIAO HO @ScienceMagazine
#Vaccinia #virus uses a multicomponent entry #fusion complex. Researchers found that A16, one component of the fusion core may regulate #lipid engagement, and F9 reinforces the prefusion architecture. https://t.co/nR4yUCr0aW

[K-P Wu @KPWu11]

https://t.co/oq6lSOG0mV
We are happy to share our work published in JACS that we found ProteinMPNN-designed protein (ubiquitin-fold proteins in this study) tends to recruit more water to for a persistent mesostructured hydration shell with enhanced stability. @IBCSinica @acsJACS

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Shih-Hsiung Wu @Sciencedirect
This study demonstrates that O-acetyl group on TSP-digested #exopolysaccharide from #Acinetobacter ##baumannii interacts with Toll-like receptor 4 macrophage and activates #immune response. https://t.co/jhW5MYcBhn
#phage

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Yusuke Nasu @RoySocChem
This newly developed #GINKO2-a #nanofibres enabled reversible #potassium detection in chemically stimulated #mammalian cells. https://t.co/VeUnp6tanv

#biochemistry #biochem #protease #protein

[IBC Academia Sinica @IBCSinica]

🔬Publication - by Dr. Ching-Ching Yu @WileyGlobal
TERS platform resolves subtle structural differences in glycosidic linkages, allows semi-quantitative estimation of chain length, and tracks enzymatic #glycosylation reactions in real time. https://t.co/C9X77HfTMM
#biochemistry

[IBC Academia Sinica @IBCSinica]

🔬Publication - by @asibc512 @ACSPublications
This study reveals that #SARSCoV2 envelope #protein, a #viroporin that drives #viral assembly, budding, and host interactions, assembles as a pentamer. https://t.co/ps0zoezDqS

#biochemistry #biochem #cryoEM

[Todd L. Lowary @Lowarylab]

Synthesis of a glycosyl phospate of glycphosphate :) https://t.co/0FLAIsFClg