Derek

[OncoDaily IO @OncoDailyIO]

Genomic Heterogeneity and Ploidy predict resistance to Anti-PD-1 Therapy in Metastatic Melanoma - @Peppe_T91

https://t.co/QXmrvR16yw

@dliu_ccb @VanAllenLab @gmboland @rhaq1

#Cancer #ImmuneOnc #IO #ImmunoOncology #Melanoma #MedEd #MedX #MedNews #Medicine #OncoDaily #Oncology

[Giuseppe Tarantino @Peppe_T91]

10/10 What’s next?
- Applying these findings to liquid biopsy & target panel sequencing data.
- Testing in larger, independent cohorts.
Check out the full study here:https://t.co/mR5JWaOxZ3

[Giuseppe Tarantino @Peppe_T91]

7/10 Subtype insights:
Non-cutaneous melanoma subtypes (e.g., Acral, Mucosal) showed:
⬆️ Higher heterogeneity
⬆️ WGD incidence
Cutaneous melanomas exhibited heterogeneity driven by non-UV mutational processes.

[Giuseppe Tarantino @Peppe_T91]

6/10 Beyond response prediction:
- Timing of whole genome doubling (WGD) affects resistance: Tumors with recent WGD (high proportion of SNV with multiplicity of 2) showed high resistance despite low heterogeneity.

[Giuseppe Tarantino @Peppe_T91]

5/10 Model performance:
Our decision tree model using heterogeneity & ploidy achieved:
✅ High specificity (97%)
✅ Strong PPV (90%)
This helps identify patients unlikely to benefit from single-agent aPD-1 ICB, who might need combo therapies.

[Giuseppe Tarantino @Peppe_T91]

4/10 Why does this matter? integrating TCGA data we show that:
- Genomic heterogeneity predicts therapy resistance.
- Ploidy offers prognostic value.
Together, they provide a precise and independent biomarker system to improve clinical decision-making. 🔬

[Giuseppe Tarantino @Peppe_T91]

3/10 Main findings:
Across different cohorts, low ploidy 📉 and high heterogeneity 📈 robustly identify patients with intrinsic resistance to aPD-1 therapy

[Giuseppe Tarantino @Peppe_T91]

2/10 What we did:
- Harmonized data across independent metastatic melanoma cohorts.
- Focused on ICB-naïve patients treated with aPD-1 therapy.
- Used whole-exome sequencing (WES), bulkRNAseq and clinical annotations

[Derek @derek_ne27]

@Peppe_T91 Congratulations, this is great work!

[Giuseppe Tarantino @Peppe_T91]

1/10🚨 New Findings Alert! 🚨
Discover how genomic heterogeneity and ploidy help predict intrinsic resistance to anti-PD-1 immune checkpoint blockade (ICB) in metastatic melanoma. 🧬https://t.co/mR5JWaOxZ3
📝 Key takeaways from our latest study: 🧵👇

[Gengey @EllisGenge]

Love this community ❤️

[Josiah Johnson @KingJosiah54]

Grizzlies: “We need you to hit a game winner in your first game back”

Ja Morant:

[Typical African @Joe__Bassey]

𝐓𝐡𝐞 𝐬𝐚𝐝 𝐭𝐫𝐮𝐭𝐡 𝐚𝐛𝐨𝐮𝐭 𝐀𝐟𝐫𝐢𝐜𝐚 𝐬𝐡𝐨𝐰𝐧 𝐨𝐧 𝐖𝐨𝐫𝐥𝐝 𝐌𝐚𝐩𝐬

If we take a look at the world map, countries like Canada, USA, Greenland, Russia etc. are very huge, and as humans we automatically get the idea: The bigger the country, the more powerful it is.

What you have not been taught in school is that all of this is a lie and the world map is incorrect. By looking at Greenland, it is big as the African continent. In reality, Africa is 14 times larger.

People who drew up maps during the colonial era (500 years ago which are still used in this day and age) purposely made Africa look smaller than the other continents when in actual fact it is the biggest alongside Asia. It was and still is a psychological way of programming people and especially Africans to think that the Europeans, Americans etc. are superior.

#Africa

[AFRICAN & BLACK HISTORY @AfricanArchives]

To those who served and loved the country that did not love them back.

Happy #VeteransDay!

[Derek @derek_ne27]

@Luke_W_Pearce @rugbyworldcup Personally, I thought the refereeing was top draw

[Ben Smoke @bencsmoke]

sorry i feel like i’m going fucking insane, israel spent days warning they were going to bomb hospitals, everyone backed them and made excuses, and then a hospital gets bombed and suddenly everyone is like - well hold on a minute! do we really know who did this?!

[Sophie Balzora, MD, FACG @SophieBalzoraMD]

It’s about that time to officially celebrate the addition of yours truly to the 0.8% of #Blackwomeninmedicine full professorship, y’all. -@nyugrossman

#diversityingi
#blackwomeninmedicine

[Frankie Boyle Updates @frankieboyle]

Being appalled by terrorism, but unfazed by genocide: the Imperial mindset

[Skip Bayless @RealSkipBayless]

Deion Sanders was better at his position (cornerback) than any NFL player has ever been at his position. AND NOW HE'S PROVING TO BE ALL-TIME AS A COACH. IMPOSSIBLY GREAT.