Derek Kleinveld

MD| PhD. Anesthesiology resident @ ErasmusMC. Interested in
trauma-induced coagulopathy, platelets, resuscitation, inflammation and organ failure.

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

❇️Best of Basic Sciences❇️

Watch an overview of “The absence of ADAMTS13 improves early outcomes in an experimental model of trauma with uncontrolled hemorrhage”

https://t.co/wdsTJSa8Kl

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

❇️Best of Basic Sciences❇️

“The absence of ADAMTS13 improves early outcomes in an experimental model of trauma with uncontrolled hemorrhage”

This study showed that knocking-out ADAMTS13 is associated with improved early survival following trauma. While ADAMTS13 activity increases after trauma and shock, its levels appear unaffected by tranexamic acid. Is current dose appropriate for protecting full length ADAMTS13?#JTACS #traumasurg #meded #surgery #emergencymedicine
@derekkleinveld

https://t.co/Uu97NleHME

[Hemostasis Today @HemostasisToday]

ADAMTS13 Plays a Novel Role in Hyperfibrinolysis After Trauma-Induced Shock
@joshuamuia | @derekkleinveld

https://t.co/jB2PW6DoYm

#ADAMTS13 #Hematology #HemostasisToday #MedX #Hyperfibrinolysis #Medicine #TraumaInducedShock #Health #MedEd

[Intensive Care Medicine @yourICM]

🪡@yourICM most liked/shared (on #SoMe) articles for 2023... 🧵6th & last post
🫀 Valvular procedures
🔓 https://t.co/Ohuw386WKS
🫀 Cardiogenic shock
🔓 https://t.co/xwG573LiSG
🩸Coagulation & periop bleeding
🔓 https://t.co/7gJdrhhbZN
💨 HFNO
🔓 https://t.co/4AcWyvUhS0

#FOAMcc

[Karim Brohi @karimbrohi]

A massive day for UK trauma with the publication in @JAMA_current of two game-changing trauma trials: @CRYOSTAT_2 and @UKREBOATrial.
Both turning points in how we understand and treat trauma patients.

UK-REBOA: https://t.co/PLEs7LXZ5o
CRYOSTAT-2:
https://t.co/U9Yv0857JO

[Intensive Care Medicine @yourICM]

🦟💉IV artesunate in bleeding severe #trauma does NOT ⬇️ multi-organ dysfunction + may be associated with ⬆️ VTE
TOP-ART RCT🔓#FOAMcc
🖇️https://t.co/3cNCqnrY7e

With editorial on targeting inflammation (& carrying-out rigorous trials) in traumatic injury
🖇️https://t.co/TA4vpPry4l

[NEJM @NEJM]

Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.

[Intensive Care Medicine @yourICM]

Coagulation & perioperative bleeding
🩸fibrinogen source/dose/time
🩸Ca++: just vs citrated blood products?
🩸PCCs/factor concentrates
🩸TXA
🩸plasma: volume or coagulation?
🩸PLTs as primary components
🩸RBCs not just DO2
🩸targeted coagulation support
🖇️ https://t.co/lv1i5GoHBg

[JAMA @JAMA_current]

In this study, among patients with trauma at risk of massive transfusion, there was no significant reduction of 24-hour blood product consumption after administration of 4F-PCC, but thromboembolic events were more common. https://t.co/ZA4V4QhKtk

[British Journal of Anaesthesia @BJAJournals]

Anti-high-mobility group box-1 treatment strategies improve trauma-induced coagulopathy in a mouse model of trauma and shock. New laboratory study by Sloos et al.

#trauma #injury #bleeding

https://t.co/99L06DPqYP

[Todd Fraser @Sunnydoc72]

@oslertech @Osler_community Honoured to chat with @derekkleinveld about Trauma Induced Coagulopathy in this fascinating new podcast released on Osler today!

[Osler @oslertech]

New podcast just released on Osler!

Trauma induced coagulopathy with Derek Kleinveld

https://t.co/HZC8baL7n7

#medtwitter #trauma #FOAMed #FOAMcc #emergencymedicine #emergencyphysician #ICU #intensivist #intensivecare #resuscitation

[Karim Brohi @karimbrohi]

Really horrendous scenes of destruction in Turkey and Syria today. Hard to know what to say but wishing the best for everyone. I know UK teams are heading out to do what they can to help. Terrible.

[Todd Fraser @Sunnydoc72]

Delighted to chat to @derekkleinveld about trauma-induced coagulopathy, haemostatic resuscitation, permissive hypotension and blood products tonight

Keep an eye out for it on @oslertech / https://t.co/1c5gn7bpkR in the next few days

[Maurizio Cecconi @DrMCecconi]

What a tragedy for our community: Sophie Hamada died on the 16th of August. She was an exceptional clinician and researcher with major roles at @esicm. And for anyone of us who has been lucky to meet her, a wonderful person, we will greatly miss.
https://t.co/OIp9Nk8faB

[Anesthesie.Reanimation.HEGP @Anesth_Rea_HEGP]

Nous avons l’infinie tristesse de vous annoncer le décès accidentel de la Pr Sophie Hamada, notre collègue, notre amie.C’était une lumière.Notre chagrin est immense.Nous adressons nos plus sincères condoléances à sa famille, à ses proches et à tous ceux qui l’ont connue et aimée.

[Claudio Sandroni @ClaudioSandron3]

Our mini-review on Trauma-Induced Coagulopathy is online. Do not miss the Supplementary Material!
https://t.co/14GuWSoKgC

[Intensive Care Medicine @yourICM]

Bleeding leading preventable cause of death in trauma: understand, detect, treat trauma-induced coagulopathy pivotal to improve outcomes
🩸pathophysiology
🩸diagnosis
🩸management
🩸knowledge gaps/future development
DON'T miss supplementary file
#FOAMcc
🖇 https://t.co/Dc7Duf5teK

[Jan Voorberg @VoorbergJ]

Still 6 days to apply for these very interesting positions. Apply and help us to further improve platelet transfusions through system biology approaches @ISTH @ASH_hematology

Postdoc / PI TRACK AND TRACE: system biology of platelet transfusions https://t.co/0lkJT2nvNg

[Karim Brohi @karimbrohi]

Great to see MODET (Multiple Organ Dysfunction in Elderly Trauma) published. 1316 critical care trauma patients enrolled across the four @London_Trauma MTCs, under the leadership of @TraumaEMC. Lots of take-homes about MODS and about elderly trauma care.

https://t.co/5PZg74isHy