Greg /dd

Just a software guy building Don’t Die

[Derek Thompson @DKThomp]

This has quietly been a miracle month in medicine.

In the last 5 weeks we’ve got news on:

- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors

This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

[Mark Ajzenstadt @mardehaym]

None of this is satire.

→ A company spent $500,000,000 on Claude in one month because nobody set usage limits

→ Uber ran leaderboards ranking engineers by how much AI they used, not what they shipped

→ Uber burned their entire 2026 budget by April. Their COO said he can’t connect any of it to consumer features

→ A CTO told Axios employees were using enterprise AI to check the weather

→ Microsoft canceled most Claude Code licenses because the token bill spiraled

→ Companies are now laying people off to pay the AI bill. Not because AI replaced the work. Because the bill replaced the headcount.

[Greg /dd @devgregfong]

If you knew you were only 500 prompts away from becoming a billionaire, you’d prompt as much as you could.

[Carnivore Aurelius ©🥩 ☀️🦙 @AlpacaAurelius]

you need to be delusionally optimistic

negative thinking poisons your brain and leads to congitive decline

whereas positive thinking, and gaslighting yourself into thinking everything is amazing, ACTUALLY makes your life amazing too.

you must be a silly goose

[Greg /dd @devgregfong]

Everyone has different starting points but the same potential

[Garry Tan @garrytan]

2026 and onwards is truly the age of open source

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

most people have no idea what is coming

- genome sequencing just crossed $100, down from $100M in 25 years
- peptides just went from felony to federal policy
- psychedelics just got a presidential executive order
- epigenetic reprogramming just entered human trials for the first time in history
- embryo editing is no longer a thought experiment: it is a clinical conversation

every single thing bio/acc has been bullish about for 2 years is breaking out simultaneously

honestly not a trend anymore

this is an inflection point

the next 6-12 months will be the most important period in the history of human biology

bio/acc

[Ben Lang @benln]

YC on how to build a company with AI from the ground up:

[Garry Tan @garrytan]

If you are in startups or tech

It is literally cook or be cooked

[Priyanka Vergadia @pvergadia]

🤯BREAKING: Researchers just mathematically proved that AI layoffs will collapse the economy: and every CEO already knows it.

The AI Layoff Trap. A game theory paper from UPenn + Boston University is glaringly important!

100K+ tech layoffs in 2025. 80% of US workers exposed. And no market force can stop it.

→ Every company fires workers to cut costs
→ Every fired worker stops buying products
→ Revenue collapses across every sector
→ The companies that fired everyone go bankrupt

It's a Prisoner's Dilemma with math behind it. Automate and you survive short-term. Don't automate and your competitor kills you. But everyone automating destroys the demand that makes all companies viable.

UBI (universal basic income) won't fix it.
Profit taxes won't fix it.
The researchers found only one solution: a Pigouvian automation tax "robot tax"

The AI trap on the economy is here!

[North@CreaoAI @anorth_chen]

Peter是我们的CTO，一个月前他开始实施新构建的AI-First的工作方式，结果是显而易见的，我们现在每天至少有20个PR会合并上线。产品changlog可以��常直观的体现我们团队的效率：https://t.co/pZdAcGQG9Q

没想到他会写文章把这么干货的实践经验分享出来。

我���荐X上所有的founders好好读一下这篇文章，如果你们团队还在以AI-assisted而不是AI-first的方式去运转，很可能会在未来一年以内就逐渐淡出这个市场了。

[Chamath Palihapitiya @chamath]

When your working life rewards you, it’s easy to ratchet up the complexity: homes, cars, travel, possessions etc.

I have found that all that complexity comes at the sake of your most fleeting asset: your time. Instead of building things, all of a sudden you’re dealing with minutiae and logistics. Instead of talking mostly to engineers, you’re talking mostly to non-engineers. The building stops…the business of managing self inflicted complexity begins.

It’s worth noting that the best players in the game (Buffett, Elon) have kept their life extremely basic, almost monastic/nomadic, as success ratcheted them ever higher.

I think it’s the biggest secret hiding in plain sight:

When the world upgrades your status, downgrade your complexity.

[signüll @signulll]

ai is exposing everyone right now & making legacy entities vulnerable af. even labs are having a tough time shipping features that feel really good end to end.

most ppl fail to realize that the hard part of building ai stuff was never access to a good model, it's the orchestration layer, the data plumbing, the taste in knowing when ai should intervene vs shut up, how it should intervene, what it should say, how it should say it, how does human in the loop work.. among many other subtle things. copilot is a prime time example of this.

most legacy players have none of these instincts cuz they built their orgs around shipping deterministic software. we are firmly in the non deterministic era now & that requires a very different skillset to build great tools.

[Daniel Ch @chddaniel]

so you're telling me Claude Code Opus 4.6 can now...

- scan an entire website
- build it as a mobile app
- prepare for App Store submission
- self-maintain the app

without any human in the loop?!?

it's so over...

[shirish @shiri_shh]

bro was right.

Atlassian down 75%. HubSpot down 69%. Figma down 86%.

Almost all of them down 30–70% from their 52-week highs.

AI is literally eating software alive and repricing every company in real time.

SaaS is cooked fr 😭

[Aakash Gupta @aakashgupta]

Erythritol is in every keto protein bar, every "zero sugar" energy drink, and every stevia packet on your table. The FDA approved it in 2001. A $275 million market. And researchers just watched it destroy brain blood vessel cells in three hours at the dose you get from a single drink.

Here's what happened at the cellular level. University of Colorado Boulder exposed human brain microvascular endothelial cells to 6 millimolar erythritol, the concentration in one sugar-free beverage. Reactive oxygen species production doubled. Nitric oxide, the molecule that keeps your blood vessels relaxed and open, dropped 20%. Endothelin-1, the most potent vasoconstrictor your endothelium produces, jumped 30%. And when they challenged the cells with thrombin to simulate a clotting event, the cells' ability to produce t-PA, the enzyme that dissolves blood clots, was completely blunted.

Less vessel relaxation. More vessel constriction. Worse clot-busting capacity. That's three independent pathways to stroke, all triggered by a single serving.

This isn't the first signal. Cleveland Clinic tracked 4,000+ patients in 2023 and found those with the highest blood erythritol levels were roughly twice as likely to suffer a heart attack or stroke over three years. Two times the risk. On par with diabetes as a cardiac risk factor. And erythritol doesn't metabolize. Your body absorbs it in the small intestine, dumps it into the bloodstream, and excretes it through urine almost completely intact. Every serving stacks on the last one.

The population most aggressively consuming erythritol, people with obesity, diabetes, and metabolic syndrome, is the exact population with the highest baseline cardiovascular risk. The sweetener marketed as their safe alternative may be compounding the problem it was sold to solve.

[Chris Bakke @ChrisJBakke]

Running a company:

2020: can you survive a pandemic?

2021: still here? we’re going to give all of your competitors $100m series A rounds.

2022: wow, you made it? okay, all engineers cost $600,000/year now.

2023: nice job! okay, SVB failed and we’re going to take away your bank account.

2024: a survivor I see. but can you pivot from ai to crypto to defense tech back to ai-enabled defense tech in a 12 month period to stay relevant?

2025: unfortunately all of your competitors have raised $2b series B rounds. oh and only 500 engineers are relevant and they cost $100m/yr each.

2026: well, well, well. you’re still in business? let’s deploy the thunderclap of godlike LLMs from the heavens so all of your customers can rebuild your app in 2 hours. can you survive?

[Aakash Gupta @aakashgupta]

Anthropic just mass-obsoleted every agent orchestration startup in a single launch.

The screenshot tells the full story. That's a production fleet dashboard. 8 agents running. 247 completed tasks. Active status. MCP-connected to HubSpot, pulling deals, generating proposals, reading attachments. This isn't a demo. It's a managed production environment where you define the agent and Anthropic runs the infrastructure.

The timing here is surgical. Four days ago, Anthropic blocked OpenClaw and every third-party harness from using subscription credentials. The message was clear: stop building on top of our consumer auth layer. Now here's the replacement. A first-party managed agent platform with fleet monitoring, production-grade MCP integrations, and prototype-to-launch timelines measured in days.

Manus spent six months on five harness rewrites. LangChain spent a year on four architectures. Anthropic just shipped the managed version that eliminates the need to build one at all.

The real bet: most companies don't want to build agent infrastructure. They want agents that work. Anthropic is pricing this into the platform the same way AWS priced server management into EC2. The 46% of enterprises citing "integration with existing systems" as their primary agent challenge just got a first-party answer from the model provider itself.

Every agent startup that raised on "we make Claude reliable in production" just lost their pitch deck.

[Rabi Shanker Guha @rabi_guha]

notice something?

Linear, PostHog, Attio - all shipped the same thing in the last few weeks. Homepage is a chat bar - not a dashboard.

This is the SaaS industry quietly admitting that traditional UI doesn't work anymore. Every user is different. One homepage can't serve them all.

The playbook is shifting:
→ expose your core APIs
→ connect an agentic layer
→ let users use software the way they want

SaaS became chat. Chat will become Generative UI - the agent won't just reply in text, it will compose the interface itself.

We're closer than people think.

[Nav Toor @heynavtoor]

🚨 Someone reverse-engineered the design systems of Apple, Spotify, Airbnb, and 30+ billion-dollar companies.

Packed each one into a single file. Free.

It's called Awesome Design MD.

Drop one file into your project. Your AI agent builds UI that looks like Spotify. Or Apple. Or Airbnb. Instantly.

Not screenshots. Not Figma links. A single DESIGN .md file that captures every color, font, spacing value, button style, and layout pattern from a real website. In a format AI agents read and reproduce.

Here's the difference:

Tell Claude Code "build me a landing page" and it gives you generic UI.

Tell Claude Code "build me a landing page" with Spotify's DESIGN .md in your project and it gives you Spotify.

Here's what's inside:

→ Apple. Premium white space, SF Pro typography, cinematic imagery.
→ Spotify. Vibrant green on dark, bold type, album-art-driven layout.
→ Airbnb. Warm coral accent, photography-driven, rounded UI.
→ Linear. Ultra-minimal, precise spacing, purple accent.
→ SpaceX. Stark black and white, full-bleed imagery, futuristic.
→ BMW. Dark premium surfaces, precise German engineering aesthetic.
→ NVIDIA. Green-black energy, technical power aesthetic.
→ Uber. Bold black and white, tight type, urban energy.
→ Sentry, PostHog, Raycast, Cursor, ElevenLabs, and 20+ more.

Here's how to use it:

→ Pick a design system from the collection
→ Copy the DESIGN .md file into your project root
→ Tell your AI agent to use it
→ Get UI that matches the design language of a billion-dollar company

That's it. One file. Your AI agent now has the design taste of a $200/hour design consultant.

Designers charge $5,000+ for a custom design system. Companies spend $50,000+ building one from scratch.

This is free. 31 design systems. Copy. Paste. Ship beautiful UI.

Works with Claude Code, Cursor, Codex, and any AI coding agent that reads project files.

100% Open Source. MIT License.