@StructBioinfo@joshiphy Interesting! I remember our one trip to Shimla a couple of decades ago and I ate a unique fruit I'd never encountered in Pune/Mumbai. But this isn't it. I guess we were in the wrong season or just totally missed this fruit in the market.
One of my favorite examples of how a change of a single atom can cause havoc: Vancomycin, often the "antibiotic of last resort", loses efficacy by 1000-fold when a single N atom is mutated to an O by the bacterium (causing repulsion instead of a hydrogen bond).
💥Cheeky 'little' update from @GencodeGenes v47, almost doubling the number of #lncRNA genes & ~4x more lncRNA transcripts. This was highlighted by @1QINGWANG when observing the greater quality of our reference-guided de novo TxOme assemblies from deep direct RNA sequencing data
@JasonSynaptic@McKnightFdn@alzassociation We got through it alright, but we also got super lucky with our neighborhood being spared. Most of the city didn't fare so well (lots of downed trees, power out for days, and flooding in some areas). Cleanup is still ongoing, but things are in pretty decent shape now.
@JasonSynaptic@McKnightFdn@alzassociation Cool work, Jason! Looks like we'll have to bring you back to USF to talk about this work. Probably for our Byrd Alz seminar series instead of the Bioscience seminar series (where you presented last time)!
The @NWSNHC forecasts 10-15 feet of storm surge in Pinellas from Wed. to Thurs. That's enough to carry away a car, inundate a house, & kill you. If you are under an evacuation order, get detailed information on where to go & what to do before you leave. #PCMilton
@JSheltzer *Fire and Mello got it for RNAi, to be accurate, but miRNAs were strongly linked to the RNAi phenomenon therefore Ambros's name came up, as I remember.
@JSheltzer Hmm sounds somewhat like the UPenn and Kariko situation. I remember when Fire and Mello got the Nobel for miRNAs that Ambros's name came up a lot for having been skipped.