didi

#donotcomply with involuntary infection of a virus of unknown origin. I can afford to mask but can’t afford to be sick 💸

[Conor Browne @brownecfm]

I could not agree more with Dr. Proal here. The lack of discussion in the longevity / healthspan space regarding the impacts of infections with pathogens has always baffled me.

[Amy Proal, PhD @microbeminded2]

It's madness that most people in the healthspan-extension space do little to control the activity of #viral, bacterial, #parasite and other pathogens that can hack their bodies over time.

Come listen to me talk at the Liberty Hotel next Thurs where I will discuss how to change this by optimizing anti-pathogen treatment approaches!

https://t.co/6XIhPz54tB

[Plague Poems @PlaguePoems]

When asked
why he was masked
the Tour de France cyclist
Jonas Vingegaard explained
there was already sickness
in the peloton and thus:
“better safe than sorry,”
so the next time you are asked
why you are masked
reply that you are preparing
for the Tour de France.

[Yuling Chow @yulingchow]

Even gets his barber to wear one too.

[Deborah Holloway 😷 🇺🇦🇨🇦 @DebHolloway]

"Matt Fitzgerald, 55, an endurance athlete, author and coach who has written nearly 40 books about running (with another, “Dying to Run,” coming out in September) and finished 50 marathons, got long Covid in 2020 and found himself unable to walk. “With most injuries, you can still find something else,” he said. But Mr. Fitzgerald found out through trial and error that exercise made him feel worse." https://t.co/f1dOK9pXjz

[Jon Douglas @atranscendedman]

Zhengzhou researchers built a lab platform that uses the body’s own protein disposal system to destroy viral proteins.

It degraded SARS-CoV-2 Spike from both the original virus and Omicron in cells and also blocked AAV in mice.

https://t.co/KuitIRAz3m

[Ivan l'Africain @AlterIvan1]

You'll see the same pattern in the news across EU countries, but so far only in Spain has anyone said it like it is 💀

[Al Haddrell @ukhadds]

Far-UVC is rapidly being recognised as an effective way to reduce the amount of infectious pathogens in indoor air

Given the importance of player's health when it comes to their performance, it's not surprising to see NFL teams utilising this new tech

https://t.co/ecf0UCLnPf

[Harry Spoelstra @HarrySpoelstra]

Less severe endothelial injury and vascular pathway activation in SARS-CoV-2 Omicron variant compared to Alpha

🚨Even mild, vaccinated Omicron cases still damage blood vessels, and probably reinfections are making things worse!

➡️This Interesting Belgium study compared vascular and endothelial effects in hospitalized COVID-19 patients. The Omicron group (≈80 % vaccinated, mostly B.1.1.529, milder symptoms) was contrasted with earlier Alpha-variant cases.

➡️Key findings:
- Omicron patients showed a less pronounced inflammatory profile and lacked the specific damaging pathway activations (e.g. PARP1, renin-angiotensin system) seen in severe Alpha cases.
- Alpha drove stronger cytokine release and a more intense “vasculoinflammatory” loop.

➡️Nevertheless, Omicron patients still displayed clear evidence of endothelial involvement, including activation of key regulators of vascular homeostasis such as TRAIL-R2 and IL-6.

➡️Both variants alter vascular proteins, but Omicron’s effects are attenuated compared with Alpha.

➡️The authors state that endothelial dysfunction may occur even in milder forms of the disease.

➡️Cardiovascular monitoring is warranted during and post-infection regardless of symptom severity or vaccination status.

“Even in mostly vaccinated patients with milder Omicron infection, these patients still display evidence of endothelial involvement, including activation of TRAIL-R2 and IL-6. These findings suggest that endothelial dysfunction may occur even in milder forms of the disease, supporting the need for cardiovascular monitoring during viral infections, regardless of symptom severity or vaccination status.”

‼️So, even in mostly vaccinated patients with milder Omicron infection, endothelial involvement persists through activation of TRAIL-R2 and IL-6, showing that vascular damage occurs even in milder forms. With ongoing mutational evolution of SARSCoV2 driving stronger immune evasion, natural waning of immunity, the large majority of people not updated with current vaccines, and growing evidence that each successive infection adds cumulative endothelial and systemic damage, the risk of repeated vascular injury is increasing, making cardiovascular monitoring essential regardless of symptom severity or vaccination status. My call for CAUTION is only reinforced!
#AvoidSars2 #AvoidReinfections #GetVaccineUpdated
https://t.co/qjhtnuvBZV

[chantzy @chantz_y]

🎯

[Harry Spoelstra @HarrySpoelstra]

SARS COV-2: CROSSING ITS RESPIRATORY BORDERS

🚨Still think “mild” Covid-19 is “just a cold” for you and your children?😧

Insights from an infectious disease specialist at Mount Elizabeth Novena Hospital, Singapore, worth your time and attention!

This paper reviews, as the author mentioned, some of the intriguing and still poorly understood extra-pulmonary complications of COVID-19, focusing on its links to diabetes, cerebrovascular disease, dementia, and Long COVID (PASC), while noting that these represent only a selection of the many virus’s systemic effects.( My note: All are actually "LC"!!)

➡️COVID-19 caused >7 million official deaths, but the true burden lies in extra-pulmonary complications including thromboembolism, stroke, cardiovascular events, autoimmune diseases, new-onset diabetes, dementia, and Long COVID (PASC),

➡️Risks persist and recur with reinfections despite Omicron’s lower virulence,

➡️Diabetes mellitus:
- Post-infection risk rises in children and adults (HR 1.1–1.6),
- Meta-analyses show elevated incidence and ketoacidosis in the first two years,
- Vaccination (especially full doses) appears protective: unvaccinated individuals and older age are key risk factors.
- Pathophysiology involves direct pancreatic β-cell damage via ACE2, autoimmunity, and molecular mimicry.

➡️Cerebrovascular disease (stroke):
- ~2.6% risk post-COVID, driven by cardioembolic/cryptogenic mechanisms rather than traditional atherosclerosis.
- Strong links exist with diabetes, hypertension, coronary disease, and atrial fibrillation.
- Mechanisms include endothelial dysfunction, cytokine storm, platelet activation, and possible direct viral neuroinvasion.

➡️Dementia and cognitive decline:
- Survivors face significantly higher risks of Alzheimer’s (HR 1.50), dementia (HR 1.66), and Parkinson’s (HR 1.44).
- 65% of patients >65 show cognitive impairment (average MoCA 23.3/30).
- Deficits equate to 3–9 IQ-point losses depending on severity, and reinfections add further decline.
- Pre-existing dementia worsens markedly.

➡️Long COVID (PASC):
- Affects 6–7% of adults and 1% of children as a multisystem chronic condition (≥3 months) featuring brain fog, fatigue, and dysautonomia.
- Even mild cases contribute heavily.
- Vaccines and early antivirals reduce risk.
- No specific cure exists, only supportive care.
- Prevention remains key: Masks, distancing, ventilation, updated vaccination, and timely antivirals (e.g., nirmatrelvir-ritonavir) effectively lower infection and complication rates.

‼️So, AGAIN, 6 years on, SARS-CoV-2 has revealed itself not as a simple respiratory virus but as a systemic pathogen that quietly seeds diabetes, strokes, dementia, and lifelong disability in millions, even after “mild” infections( All are actually "LC"). With no end to mutations and reinfections guaranteed, the only rational defence is relentless prevention: vaccination, antivirals, and non-pharmaceutical measures. Anything less condemns society to an accumulating, invisible epidemic of chronic disease. 👏This colleague understands the gravity of the ongoing pandemic!
#AvoidSars2 #AvoidReinfections
https://t.co/hf73r9wPQm

[didi @didi43780129]

@Engineer_Wong So sorry for your loss 😔

[Jon Douglas @atranscendedman]

Columbia researchers studied 26,039 people and found preexisting chronic kidney disease predicted a weaker antibody response after COVID vaccination and a higher risk of severe COVID.

Long COVID increased only in the most advanced kidney disease.

https://t.co/7XgJTFDIrs

[didi @didi43780129]

@singingsox I bought a rebounder and am doing health bounces on it. It’s supposed to help with lymphatic drainage. I can’t tell whether it works or not, but it’s the only exercise I don’t hate

[Liam's LC/ME Journey @liamsLCjourney]

Until now, there has not been a list of recommended UK Long COVID and ME doctors all in one place... so we decided to make one!

https://t.co/NnYarA6rEq 🇬🇧

We painstakingly collated hundreds of comments from Reddit, Twitter, and group chats with only the most-rated doctors, pricing, and pros and cons from real patients.

25 doctors and clinics are listed, from NHS to private specialists, pharmacies for LDN and ketotifen, and even a link-out to @ChronicLiving1 for therapy options!

This is a living document and will be continually updated. Suggestions and updates welcome!

[Carnivora  @CarnivoraCC]

After yesterday’s huge setback I try to rise from the ashes like a phoenix.

https://t.co/xUljuOU3J3

I’m not giving up on my goal to become a #covidcautious counsellor so easily - for myself but also for this community here.

Sharing is caring 💗

[Adam Wong @Engineer_Wong]

We're having a 8% off sitewide sale on https://t.co/wGjfB5ut2O from June 23 to 27. Don't miss it!

[didi @didi43780129]

@DaniBeckman @DeepPiction Fascinating

[Danilo.Buonsenso_Surf4Children @surf4children]

if you have, or suspect to have, either #longcovid or #mecfs you will not find a better free tool to start your journey toward recognition and care. bookmarking it

https://t.co/QwkEBI5Bzp

[Zdenek Vrozina @ZdenekVrozina]

You have hypertension. Blood pressure controlled. eGFR normal. Acute COVID behind you. Everything fine?
A new study suggests - maybe not. Your kidney may be functioning at rest, but its reserve is quietly eroding.🧵