Dominika Borek

[Dominika Borek @dmborek]

New paper: https://t.co/x3gpyNIWZw ! We finally get to see native chlamydial MOMP by cryo-EM: a trimer with three β-barrels topped by a folded antigenic cap. It is strange, beautiful, and full of clues for vaccine design. (1/5)

[Dominika Borek @dmborek]

Cryo-electron tomography reveals OmpB is required for the Rickettsia parkeri S-layer https://t.co/lAucGiB8uV

[Dominika Borek @dmborek]

Seeing the structure makes old observations click — adhesion, redox, antibody recognition, vaccine design. Also: the transparent peer-review file has hidden gems; the reviewers pushed the story in the best way. Huge thanks to all co-authors! (5/5) https://t.co/ytfQHfHX1N

[Dominika Borek @dmborek]

New paper: https://t.co/x3gpyNIWZw ! We finally get to see native chlamydial MOMP by cryo-EM: a trimer with three β-barrels topped by a folded antigenic cap. It is strange, beautiful, and full of clues for vaccine design. (1/5)

[Dominika Borek @dmborek]

The cap is where the immune story gets exciting: variable domains from all three protomers make one antigenic surface, and antibody binding reshapes it. This is why native structure matters for MOMP vaccine design. (4/5)

[UT Southwestern Medical Center @UTSWMedCenter]

A vaccine to prevent chlamydia, the most common sexually transmitted infection, could be closer to reality. #UTSW scientists helped map a key protein on the bacterium that causes chlamydia, offering hope for treating this source of serious health problems. https://t.co/kN0EwQOTj8

[Ah-Ram Kim @ahramkim1128]

The distinct trimeric structure of the immunodominant chlamydial antigen Major Outer Membrane Protein
https://t.co/XMdgbDLu9C

[Deniz Kavi @kavi_deniz]

RFdiffusion3 now available! De novo protein design against any molecule

Try it on @tamarindbio today

RF3 shows success in designing de novo proteins against all-atom targets, including proteins, DNA and small molecules with diverse applications.

[Marty Taylor, MD PhD @DrMartyTaylor]

How can the same "master regulatory" protein mTOR recognize different sets of targets to separate nutrient and growth factor signals?

Thrilled to share our new paper, in which we reveal how mTORC2 recognizes Akt.

🧵 on our new paper in Science:
https://t.co/PSZWMsEYbn

[Taekjip Ha @taekjip]

Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues | PNAS https://t.co/T6JXIq1HBp

[Wolf Lab @HiCryoEM]

First cryo-EM map of Apoferritin from our new @JEOL_Japan @JEOLUSA @JEOLEUROPE cryoARM300-II with @DirectElectron Apollo detector. Collected over night and processed in 1 day with @cryosparc using all-default settings from only 76k particles. H/R B-factor=28 at 1.5A. Not too shabby!

[Jeannie Lee @XistHarvard]

An evolving landscape of PRC2–RNA interactions in chromatin regulation, by Aguilar @ragmau, Rosenberg, et al. now in print!

Learn the latest about how Polycomb works with RNA in epigenetic regulation:

https://t.co/Ok7OXu2q6j

[Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social @RolandDunbrack]

Turns out they said yes! https://t.co/d4IS80nA01

[Nicastro Lab @NicastroLab]

🎉 Congrats to Yanhe, Kangkang, @AmirrasoulTava1, @loonggui & co-authors for revealing the atomic structure of RS3, a Giga-sized complex in motile cilia! A tour de force in #cryoET, #cryoEM,#proteomics & modeling. Out now in Nat Struct Mol Biol! https://t.co/jTYqhpOEgC @CellUtsw

[Structure @Structure_CP]

AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys https://t.co/OfHGM3azg6

[The Nogales Lab @NogalesLab]

Our work, co-led by @AlfredoFlorez and @NicholasLue, is finally out in @NatureSMB. Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and Susanne Kassube for their contributions, and thanks to the reviewers for their suggestions that led to the final work.
https://t.co/JANL7JQJca

[Juha Huiskonen @JuhaHuiskonen]

In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.

[Mike Martynowycz @ScienceMick]

🍃➡️🧬 First paper from the Martynowycz Lab!
Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias.

Watch the diffraction-to-density movie & grab the preprint below!

https://t.co/6FJWU5gg4S

[Naruhiko Adachi @NaruhikoAdachi]

The 32nd paper from the #cryoEM facility in #KEK. Collaboration with Profs. Noji and Murata. Multi-stalk FoF1-ATP synthase was engineered to enhance H+/ATP ratio. Cryo-EM structures clearly showed the presence of multi-stalks! Outstanding work, Ueno-san!

https://t.co/0SIa04SSoM