Gitte Pedersen

RNA Platform for Next Generation Cures. By analyzing RNA we can detect disease, monitor health and design next generation cures #RNA #AI #Cancer

[Gitte Pedersen @DNABARCODE]

My review of Bruce Ratner's book "Early Detection", it details the profound impact of #cancer screening tests, like the PAP smear, which almost eliminated mortality from cervical cancer - what if we can do that for more cancers ?
https://t.co/cwTyEJyViX?

[Gitte Pedersen @DNABARCODE]

@UrnovFyodor @EricTopol How do you know it’s only 3 weeks? Publications?

[Eric Topol @EricTopol]

Another major advance vs cancer! @ASCO #ASCO26
Personalized neoantigen mRNA vaccine 5 year follow-up vs metastatic melanoma reduced recurrence and death by 49% (on top of Keytruda)
https://t.co/NadITTYIT2

[Gitte Pedersen @DNABARCODE]

@vladileshko @DeryaTR_ Great question!

[Derya Unutmaz, MD @DeryaTR_]

Another major cancer treatment advance with a personalized mRNA vaccine for melanoma, on top of immune therapy, >70% survival! This fully mobilizes the immune system to destroy the tumor. In fact, it could potentially be applied to most cancers that have specific mutations!

[Gitte Pedersen @DNABARCODE]

@exosome What does it mean from a disease and aging standpoint?

[Gitte Pedersen @DNABARCODE]

Standing ovation for @RevolutionBio after presenting their data from #KRAS inhibitor in #pancreatic cancer - the hardest to treat and the toughest target - just wow @DrSamuelBHume congratulations

[Samuel Hume @DrSamuelBHume]

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results

I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

[SciTech Girl @scitechgirl]

🧠 SCIENTISTS MAY HAVE FOUND A SURPRISING WAY TO REVERSE MEMORY LOSS

What if one tiny element already found in the brain could help fight Alzheimer's disease?

Researchers discovered that restoring natural lithium levels in the brain reversed memory loss and improved brain function in experimental studies. The findings suggest that a shortage of lithium may play a role in Alzheimer's, opening a new path for future treatments.

It's still early research, but the results are giving scientists fresh hope that memory loss may not always be permanent.

Source:
University of São Paulo. Replenishing natural brain lithium levels reverses memory loss associated with Alzheimer's disease.

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[Gitte Pedersen @DNABARCODE]

Vitamin D analog improves #pancreatic #cancer survival

[Eric Topol @EricTopol]

A small randomized trial in patients with metastatic pancreatic cancer found benefit for paricalcitol, a Vitamin D analog https://t.co/CDnIwm0xeo
Good @salkinstitute explainer https://t.co/QgEKHiquIa

[Gitte Pedersen @DNABARCODE]

The story of the “undruggable” #KRAS

[Nate Krah @N8Krah]

🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵

[Eric Topol @EricTopol]

The immune system in centenarians is remarkably youthful, far less prone to inflammaging
@NatRevImmunol https://t.co/J3WD9hVs7j

[Gitte Pedersen @DNABARCODE]

David Sinclair that is very interesting - always thought that there was a link to infectious agent but had not guessed gum bacteria #alzheimer

[David Sinclair @davidasinclair]

Would be shocking if bacteria that cause gum disease also contribute to Alzheimer’s.

Either way, to reduce overall inflammation, maintain oral heath by:

1. Flossing daily
2. Using an electric toothbrush
3. Seeing a dentist >2x a year
4. Chewing oral probiotics

🦷🧠💪

[Gitte Pedersen @DNABARCODE]

@EricTopol That map says a lot

[Gitte Pedersen @DNABARCODE]

Uplifting story thank you Chaz for sharing #ovarian #cancer

[Chaz Hong MD PhD 🇺🇸 @chaz_hong]

I am reminded once again that research matters.
My wife’s friend was diagnosed with metastatic ovarian cancer, resistant to our favorite drug Cis/Carboplatin. Genetic testing revealed, among other things, KRAS G12A mutation. She was started on a KRAS inhibitor but unfortunately developed massive myopathy to the point she could barely walk. At that point, she needed bilateral nephrostomy tubes for renal blockage and was given weeks to live. But her mutation panel had also revealed modestly elevated tumor mutation burden (TMB) and CHEK2 mutation, which is involved in DNA damage response. Based on this (though the evidence was limited), she was started on immune checkpoint blockade (ICB) as a last-ditch effort. Since then, her tumors have melted away, and our friend is now strong enough to clear the snow during LAST NIGHT's blizzard in Northeast. Below is a photo she just sent us.
I share not just because this is a miracle, but a SCIENCE IN ACTION! #SpartansWill #ResearchSavesLives
@MSUMD, @MSU_Medicine, @HFH_MSU_HS

[Gitte Pedersen @DNABARCODE]

@chaz_hong Wow what an amazing story

[Nicholas Fabiano, MD @NTFabiano]

Addiction to short-form videos reduces brain activity in the frontal lobe weakening the ability to focus.

[Gitte Pedersen @DNABARCODE]

More #AI in #HealthcareAI @Nature cytology which is basically looking for abnormal cell under a microscope

[Eric Topol @EricTopol]

AI automates cytology, which is a laborious, manual, human subjective task, for pre=screening cells for abnormalities and making initial diagnoses
today @Nature
https://t.co/ZI3F2pkMxE
https://t.co/WsUcRjkHFN

[Gitte Pedersen @DNABARCODE]

Our immune system plays a critical role in all diseases…and now also in aging #Longivity

[Eric Topol @EricTopol]

Our immune system is the driver of the biologic process of aging. A new and comprehensive review @NatRevImmunol
https://t.co/0Fm9w7U341

[Gitte Pedersen @DNABARCODE]

@ElinaMia34 Hi hope for treatment and recovery

[Gitte Pedersen @DNABARCODE]

Great news of additional benefits from the Shingles #vaccine @EricTopol

[Eric Topol @EricTopol]

The Shingles vaccine is linked to slowing biological aging and reducing inflammation https://t.co/nTUU1Fs8de