[1/6] Buckle in for the story of a big chunk of my PhD: In our recent preprint, we explore the molecular impact of severe stress on the human brain. A thread:
A moment that felt both like it came all too quickly and was also long overdue. Thanks to everyone for the support along the way especially the @mindbehindMINDS gang❤️
Exciting new results from single nucleus RNA sequencing of 800,000 nuclei from 90 post mortem brain samples showing converging effects of ageing and #Alzheimer disease and other #psychiatric disorders.👇https://t.co/NriayHyzLj
Thrilled to share the first major publication from my thesis, huge thanks to all who were involved! If you’re interested in neural bioprinting, check out our open access manuscript below 👇
[1/6] Buckle in for the story of a big chunk of my PhD: In our recent preprint, we explore the molecular impact of severe stress on the human brain. A thread:
[6/6] Finally, we wanted to see whether human astrocytes could directly respond to stress. We activated cortisol receptors in hPSC astrocytes. Activation directly shaped the glutamate clearance and the calcium response to excitatory neurotransmitters, such as glutamate and NMDA.
Fantastic preprint out from the great lab of @natalie_matosin led by the very talented @domkaul. Congrats to all the authors for this beautiful work. A great read for anyone interested in glial biology and the role these fascinating cells play in stress.
Beyond excited to have finally submitted my thesis!!!!! A huge thank you to everyone who has helped me out along the way especially @natalie_matosin, the lab @mindbehindMINDS, @NeuralOoi, Sibylle and Naguib for all your support