Dow Lab

Cancer genetics & biology lab, building and applying new genetic technologies in search of better treatment options for cancer patients

[Dow Lab @dow_lab]

Paper day! This one is a fantastic joint effort from @alynakatti and @AdrianVegaPerez. I tweeted about this >1 year ago when the #preprint dropped, but there was a lot added in review, so... here is iBE - a new inducible #baseediting mouse model! 1/15 https://t.co/DDBc2JP6SN

[Sal Alonso @Alonso_Salv]

Our paper, co-led with @kevanchu in the @dow_lab, is out today in @Cancer_Cell. We analyzed pre-treatment, on-treatment, and post-progression biopsies from 12 CRC patients treated with KRASi + EGFRi.
https://t.co/4KsCQsagil

[Anirban Maitra @Aiims1742]

Preprint from @dow_lab @WeillCornell using CRISPR base editing screens:
Genetic mechanisms of resistance to targeted KRAS inhibition
https://t.co/2jOLx1TzM6
MAPK reactivation remains the predominant mechanism of resistance to KRASinh. Also identifies a hotspot mutation in CiC.

[Sal Alonso @Alonso_Salv]

Excited to share the preprint of my postdoc work @dow_lab and @MSKCancerCenter! Joint work with co–first author @kevanchu
Link: https://t.co/vtpuJgDRZS

[Dow Lab @dow_lab]

Haven't been on here since the first Tuesday in Nov, but...

...today I was promoted to Professor with tenure at @WeillCornell and wanted to post one last time to thank everyone that has helped our lab over the past 10 years! Science and guitar posts continue @dowlab.bsky.social

[Dow Lab @dow_lab]

Alright, America… Let’s see if we can (finally) elect a more than qualified female candidate over an abundantly unqualified male. I’m looking at you, PA & WI. Vote!!

[Dow Lab @dow_lab]

Ok, so unpopular opinion, I guess… I don’t think news entities should ever endorse political candidates.

They can and SHOULD report objectively on all the terrifying stuff coming from DJT. I’d much rather honest reporting than ‘both-sidesing’ and editorial opinions. Inform us!

[Piskounova Lab @piskounova_lab]

6 years of work +
Over 2 years in review +
1 extremely talented graduate student @LeonaNease +
Amazing collaborators =

One extremely cool new mechanism that regulates metastasis through modification of the selenocysteine tRNA!

https://t.co/V5YMhZJV2J

[Dow Lab @dow_lab]

@MarcusDGon @RobSchwartzLab I mean, if it was mouse sized…

[Dow Lab @dow_lab]

@JasonWilliamsNY

[Dow Lab @dow_lab]

@notSoJunkDNA Yup :)

[Dow Lab @dow_lab]

Guess who now gets a vote…

[Dow Lab @dow_lab]

@Aiims1742 @skopetz @DrShubhamPant @DavidHongMD No hyphen. Not authentic.

[Dow Lab @dow_lab]

@rosslevinemd Totally. 💯

[Dow Lab @dow_lab]

In no other field do you hire someone for their immense expertise in a very niche field and immediately ask them to change what they do… science is weird.

[Arjun Raj @arjunrajlab]

Can we retire the “How will you distinguish yourself from your postdoc advisor?” question that is typically asked of faculty candidates? I don’t think there is a meaningful answer that would inform a hiring decision one way or the other. Also, it’s silly.

[Arndt Vogel @ArndtVogel]

Distinct clinical outcomes & biological features of
specific KRAS mutants in human pancreatic cancer
@Cancer_Cell
https://t.co/eZ0nLO7vWT
👉KRASG12R enriched in early stage w/ reduced nodal disease + distant recurrence
👉improved OS
🧐 Supports KRAS mutational testing in #PDAC
@my@myesmo

[Fusion Conferences @Fusion_Conf]

@dow_lab we're looking forward to your presentation at #AMC25 in the Dominican Republic🇩🇴 next February! Please RT to let your followers know Talk Submission closes next week!
✅Register & Submit: https://t.co/15DMoct91z

[Dow Lab @dow_lab]

@PracheeAC Single lane, two cars, both working, make it up as you go… Does mean you don’t resent the person who ends up with the better car!

[Dow Lab @dow_lab]

@TuomasTammela Haha, thanks! But you just made me calculate out how old I will be in 5 decades... 😬

[Dow Lab @dow_lab]

10 years old today... the lab is double digits!! Happy birthday to us!

[Dow Lab @dow_lab]

@LGMartelotto You’re just gonna leave that buffer tray uncovered…? Like a psychopath? Somebody the cling wrap!