Manuel Gonzalez MD

Transplant Nephrology, passionate about them beans!!!

[Leonardo V. Riella @LVRiella]

🚨 Our New Review Out!
Ultrasound Localization Microscopy (ULM) is reshaping how we see microvasculature at unprecedented resolution. In the kidneys, glomeruli are visualized non-invasively! Great opportunities for dx https://t.co/dVSk7uiNtD @mgh_transplant @MGBKidneys
🧠🧬🩺

[Arkana Laboratories @arkanalabs]

This patient received a kidney transplant 10 days prior and is currently anuric, with delayed graft function. What is your diagnosis?

#DiagnoseThis #renal #kidneypath

[American Journal of Transplantation @amjtransplant]

#OpenAccess and in press! "dd-cfDNA Significantly Improves Rejection Yield in Kidney Transplant Biopsies" by Bromberg et al. https://t.co/KcH5ctkFsF #kidney
@CareDx

[Peter Reese @PeterPReese1]

I see progress in figuring out how to guide immunosuppression toward individual patients' needs Amazing work here by Alex Loupy’s group illuminating how cell-free DNA reveals allograft inflammation, but a clinician needs to interpret in the clinical context. @AlexandreLoupy

[Alexandre Loupy @AlexandreLoupy]

30 institutions participating in this Trial
Grateful to this amazing network !!!

[NEJM @NEJM]

Presented at #ERA24:

In this phase 2 randomized trial, the CD38 monoclonal antibody felzartamab showed acceptable safety and promising efficacy among patients with chronic antibody-mediated kidney-transplant rejection. Read the full trial results: https://t.co/S6wvGwoQqB

[Swetha Kanduri @SwethaKanduriMD]

💥Anti-Nephrin antibodies for MCD and FSGS
💥Anti-Nephrin Podocytopathy
💥Markers of disease activity 🦠
💥@NEJM #ERA2024
#FutureIsPromising

[NephSIM @Neph_SIM]

New #kidney comic: T cell Mediated Rejection #KidneyTransplant @Momen_Abbasi

https://t.co/gkaoRWUgF8

[Swetha Kanduri @SwethaKanduriMD]

Happy to share our article “Liver Diseases-Associated Glomerulopathies” @akdhjournal. Pleasure working with @SWadhwaniMD and @PelegYoni on this wonderful project. Grateful to @akdhjournal editors and reviewers for the kind support 🙏🙏
https://t.co/wYkBXMMbs2

[Sanjeev Sethi @SethiRenalPath]

I had no idea at first, then it suddenly hit me.

1. Normal glomeruli,no FSGS
2. Tubules filled with large granules
3. IF negative=not light chain tubulopathy

Chromogranin +++ in tubules

Dx: Neuroendocrine tumor-associated tubulopathy

65-yr, diabetes, HTN, pancreas mass, ⬆️ Cr

[Tiffany Caza @Tiff_Caza]

It takes a lot of courage and vulnerability to seek out a donor and self-advocate. Please consider stepping forward as a kidney donor for this young man. It can be a rewarding experience for the donor as well. Happy to answer any questions about donating too - my DMs are open.

[ASN Kidney360 @ASNKidney360]

Identification of casts by urinary sediment microscopy is a valuable diagnostic clinical tool. This Podcast discusses a study that found urinary vacuolar casts are strongly associated with advanced glomerulopathies with severe proteinuria https://t.co/v4vJawEvMO

[Mass General Brigham Nephrology @MGBKidneys]

Landmark in Transplantation👑

Genetically-edited pig kidney with 69 genomic edits successfully transplanted into a living patient!

Congrats to Dr. Riella, Dr. Kawai, Dr. Elias and the entire team!

@LVRiella

https://t.co/60keN58U0f

[Manuel Gonzalez MD @drGnephro]

@WVU_Neph @crrtonline @khaledshawwa Great job Abi!! 👏👏

[Robert Kalyesubula,MD, FISN(USA), PhD-FRCP(London) @rkalyes1]

🔥 Enjoy the kidney transplant surgery animation video!
Just 110 seconds!

[Katalin Susztak @KSusztak]

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models https://t.co/dfU0kHgR1S @LVRiella

[Mark Perazella @MPerazella]

Check out the Kidney360 February cover. Nothing better than a beautiful urine sediment image!

[Leonardo V. Riella @LVRiella]

Excited to see new treatments emerging for C3 glomerulonephritis. On this phase II study, iptacopan, a proximal complement inhibitor that binds to factor B was capable of reducing proteinuria and C3 deposits in kidney transplanted patients (n=11)with recurrent C3GN. @KIREports

[Leonardo V. Riella @LVRiella]

Normothermic machine perfusion vs. static cold storage after circulatory death kidney transplantation. Randomized trial @NatureMedicine Unfortunately, primary outcome was delayed graft function & only 1 hour of normothermic perfusion done. But first step. https://t.co/rDSWQ15ajK