The ctDNA hype cycle is over.
ASCO’s first ctDNA guideline tells us where liquid biopsy actually changes practice. 🧬
✅ Use ctDNA when:
• Tissue is unavailable or unsafe
• Results are needed urgently
• Drug approvals allow/require liquid biopsy
⚠️ Negative ctDNA does NOT exclude actionable disease.
Tissue confirmation remains critical.
Practice-changing trials cited by ASCO:
🔹 DYNAMIC
Stage II colon cancer
Less chemotherapy, same outcomes.
🔹 PADA-1
ESR1-guided switch to fulvestrant + palbociclib improved PFS.
🔹 SERENA-6
ctDNA-detected ESR1 mutations enabled earlier intervention and significantly prolonged PFS.
🔹 IMvigor011
MRD-positive bladder cancer benefited from adjuvant atezolizumab.
❌ ctDNA should not replace imaging, pathology, or standard staging.
Bottom line:
The question is no longer:
“Can we detect it in blood?”
The question is:
“Will acting on it improve outcomes?”
That’s the bar ASCO has set. 🎯
#Oncology #ctDNA #LiquidBiopsy #ASCO #PrecisionMedicine
@OncoAlert@ASCO@JCOPO_ASCO
Happy Father’s Day to the fathers of oncology.
Sidney Farber taught us cancer could be treated.
Paul Ehrlich taught us cancer could be targeted.
James Allison taught us the immune system could fight back.
Every modern oncology clinic stands on the shoulders of giants.
#FathersDay #Oncology #CancerResearch #MedTwitter
@OncoAlert@Larvol@DanaFarber
Referees better watch out for England and their excessive blocks on Tuesday. They do this a lot . We are watching paaa. @FIFAcom should enforce the rules fully
🇬🇭 The Black Stars have NEVER lost a second group-stage match at the FIFA World Cup.
2006: Ghana 2-0 Czechia
2010: Ghana 1-1 Australia
2014: Ghana 2-2 Germany
2022: Ghana 3-2 South Korea
Record in second group games:
🏆 2 Wins
🤝 2 Draws
❌ 0 Defeats
Congratulations to graduating neurosurgery chief resident Cecilia Dalle Ore, MD, who will be joining Kaiser in the Sacramento-Vacaville area! 🎉🎓#UCSFGrads#UCSFProud
Fun fact: The Black Stars have never lost a second group game at the World Cup 🇬🇭
Games: 4
Wins: 2
Draws: 2
Defeats: 0
Up Next: England
#3Sports#Mundial26OnMG#TV3GH
🚨 𝗛𝗜𝗦𝗧𝗢𝗥𝗜𝗖: Morocco have climbed to 5th in the FIFA World Rankings. 😍🇲🇦
The Moroccans have moved ahead of Portugal and Brazil. 🤯🇵🇹🇧🇷
Congratulations to the Atlas Lions, who become the first African nation to break into the Top 5 since 1994. 👏❤️