The ctDNA hype cycle is over.
ASCO’s first ctDNA guideline tells us where liquid biopsy actually changes practice. 🧬
✅ Use ctDNA when:
• Tissue is unavailable or unsafe
• Results are needed urgently
• Drug approvals allow/require liquid biopsy
⚠️ Negative ctDNA does NOT exclude actionable disease.
Tissue confirmation remains critical.
Practice-changing trials cited by ASCO:
🔹 DYNAMIC
Stage II colon cancer
Less chemotherapy, same outcomes.
🔹 PADA-1
ESR1-guided switch to fulvestrant + palbociclib improved PFS.
🔹 SERENA-6
ctDNA-detected ESR1 mutations enabled earlier intervention and significantly prolonged PFS.
🔹 IMvigor011
MRD-positive bladder cancer benefited from adjuvant atezolizumab.
❌ ctDNA should not replace imaging, pathology, or standard staging.
Bottom line:
The question is no longer:
“Can we detect it in blood?”
The question is:
“Will acting on it improve outcomes?”
That’s the bar ASCO has set. 🎯
#Oncology #ctDNA #LiquidBiopsy #ASCO #PrecisionMedicine
@OncoAlert@ASCO@JCOPO_ASCO
Cancer Statistics 2026: Now published👇
Cancer mortality has fallen 34% since 1991 (4.8M deaths averted). 5-year survival is now 70%! Metastatic disease improved from 17% to 35%.
Lung cancer remains the leading killer‼️
https://t.co/69LeIEPMwm
#OvarianCancer remains one of the most challenging gynecologic malignancies to treat, largely due to its late-stage detection and the difficulty of accessing tumors. Keep reading: https://t.co/lx2w5D4b6X #CancerResearch
30 Ağustos zaferinin 103. yıl dönümünde başta Başkumandan Gazi Mustafa Kemal Atatürk ve silah arkadaşları olmak üzere tüm kahramanlarımızı saygı ve şükranla anıyoruz
#30ağustoszaferbayramımızkutluolsun
Our special congratulations to the club's president Ali Koç, Aleksander Gomelskiy Сoach of the Year Šarūnas Jasikevičius, and Euroleague Final Four MVP Nigel Hayes-Davis.
Bravo, Fener!
Even though older adults are more likely to be diagnosed with colorectal cancer (CRC), there is a concerning rise in diagnoses among younger adults, making it essential for healthcare providers to educate adult patients of all ages about the lifestyle-related risk factors associated with the disease. https://t.co/eWM6nUUc5o
#4ŞubatDünyaKanserGünü, kanser farkındalığını artırmak, kanserin erken tanı ve tedavisini teşvik etmek için düzenlenen uluslararası bir aktivitedir. Asıl hedef kanserin ne olduğunu anlatmak ve kanser ölümlerinin önüne geçmektir
#ErkenTeşhisHayatKurtarır