Bilal Bashir

Endocrinologist | Diabetologist |
Cardiovascular Prevention | Cricket enthusiast | Hiker

[Bilal Bashir @drbilalbashir]

Delighted to present 4 abstracts at #EASCongress from the Lipoprotein Research Group at @MFTnhs including research on TG and CVD, the global FCS registry & the publication of interim HEART-2 PCSK9 gene-editing data in @NEJM led by @ScottVafai and an outstanding international team

[Pablo Corral MD @drpablocorral]

Be PRAGMATIC
Be SIMPLE

From Haffner to VESALIUS: we didn’t discover anything new… we finally accepted it.
📍 1888, Haffner (NEJM) already warned us:
👉 A patient with diabetes and no MI carries a risk similar to someone who already had one.
https://t.co/UZnxtl59hG

📍 2026 VESALIUS (JAMA) just removes the last excuse:
👉 Even before clinically evident atherosclerosis, the risk is already biologically active.
https://t.co/TerMC7yRJI

👆 Let’s be honest:
There are NO LOW-RISK patients with diabetes
There are NO INTERMEDIATE-RISK patients with diabetes

👉 There are only:
HIGH RISK
VERY HIGH RISK (most of them, if you actually look closely)

📌 The problem is not classification.
📌 The problem is clinical denial and therapeutic inertia.

We don’t undertreat diabetes because we lack evidence.
👉 We undertreat it because we are still thinking in outdated risk categories.
Atherosclerosis starts early.
Diabetes accelerates it.
And we… keep labeling instead of acting.

@society_eas
@nationallipid

[Bilal Bashir @drbilalbashir]

The genetic architecture of FCS is more complex and heterogeneous in the UK:

- 12.9% of the tested are genetically confirmed FCS
- Over half are LPL-FCS, but non-LPL FCS are equally common
- Regional & ethnic variability

https://t.co/T7lRk8Loo3

@RareDiseases @heartukcharity

[Bilal Bashir @drbilalbashir]

Neurodegeneration, neuropathy & familial chylomicronemia syndrome (FCS) — we report an under-recognised complication of this rare lipid disorder.

https://t.co/jcqo5VtEbI

[Bilal Bashir @drbilalbashir]

Our latest work shows that hypertriglyceridaemia alone can cause small fibre neuropathy and cardiac autonomic dysfunction.

https://t.co/PNJvDS6hhp

@MFT_MRI @MFTnhs @heartukcharity

[Bilal Bashir @drbilalbashir]

We reviewed how does HDL participate in atherogenesis? Antioxidant Activity Versus Role in Reverse Cholesterol Transport https://t.co/f6vkhmsJpq #mdpiantioxidants via @antioxidants_OA

[Bilal Bashir @drbilalbashir]

We quantified the clinical impact of variation on GH and IGF-1 measurements on the classification of acromegaly disease status in the UK

https://t.co/kNea6bjyCQ

@safwaan_adam

[NEJM @NEJM]

Presented at #AHA24:

In a large trial involving patients with acute myocardial infarction, 95% of whom had ST-segment elevation myocardial infarction, spironolactone did not reduce the risk of cardiovascular events. Full CLEAR trial results: https://t.co/YiRtIHAv2u

[NEJM @NEJM]

In the CLEAR randomized trial involving patients with acute myocardial infarction, colchicine did not decrease the risk of major adverse cardiovascular events over a median follow-up period of 3 years. Full trial results: https://t.co/k3fRIyyFpd

[ATVB: An AHA Journal @atvbahajournals]

Nov. Featured Article: UK FCS registry: Higher pancreatitis risks but lower ASCVD rates in FCS vs. MCS; gene distribution varies by ethnicity
https://t.co/3yCQSLG7SM

[Bilal Bashir @drbilalbashir]

#FCS is an ultra-rare disorder causing extremely high triglycerides,with significant delays in diagnosis and unmet clinical needs.Thanks to everyone who stopped by on FCS Awareness Day to learn about it
@ActionFCS @CheckOrphan @heartukcharity @MFTnhs @atherosociety @society_eas

[Bilal Bashir @drbilalbashir]

Our latest article from UK FCS National Registry has been chosen as one of the two “Featured” articles in the November 2024 issue of @atvbahajournals

https://t.co/nf5Oi8vWH9

[HEART UK @heartukcharity]

HEART UK is delighted to announce the formation of the Early Career Cardiovascular Disease Prevention (ECCDP) Network designed to bring together junior & early-career HCPs & researchers to collaborate & share expertise.

https://t.co/l0UzqQC5uW
#lipids

[Bilal Bashir @drbilalbashir]

Hypertriglyceridaemia in absence of diabetes causes peripheral & cardiac autonomic neuropathy.
@Neurodiab_eu
@heartukcharity
@OfficialUoM
@CVD_MFT
@MFT_Research

[Bilal Bashir @drbilalbashir]

FCS leads to small fibre nerve damage, clinical neuropathy & early CAN

@Neurodiab_eu
@heartukcharity
@CVD_MFT
@RareDiseases
@CheckOrphan

[Bilal Bashir @drbilalbashir]

Join researchers & clinicians at #ISA2024. Don’t miss opportunity to expand network while discussing how precision med can prevent,detect & manage cardiometabolic diseases. Use code ISAABILAL50 for discounted reg https://t.co/nBHJRhvTDx
@atherosociety
@OslaOman
@heartukcharity

[Bilal Bashir @drbilalbashir]

Cardivascular risk extends beyond LDL-C, but are their any other therapeutic targets? Does lowering triglycerides help?

https://t.co/MD2qeLh138

[MFT Research and Innovation @MFT_Research]

📰 Congratulations to the ‘Balance' study team at @MFTnhs, led nationally by UK Lead, Prof Handrean Soran. The global research published in @NEJM into the rare genetic condition FCS has revealed the life-saving potential for new drug olezarsen.

👇
https://t.co/1u3uwVjUx3

[Bilal Bashir @drbilalbashir]

We presented 4 papers at 37th Annual HEART UK conference.

@rarediseaseuk
@heartukcharity
@CVD_MFT
@MFT_Research
@MFTnhs
#HUK
#lipids

[CardiovascularMFT @CVD_MFT]

The 2nd talk by @drbilalbashir was on 'Hypertriglyceridaemia and Cardiovascular Autonomic Function in Patients Without Diabete Mellitus'