@crnvr_invictus@Diet0Nutrition Did you not read the study I linked? We're not talking about waiting until the LDL gets oxidized to oxLDL. We're talking about documented effects on things like FMD from native LDL.
@KenCaptn20114@StillmanMD He's saying that mortality benefit isn't what we think. Weighing into this are risks of overtreatment, which are substantial. Most people would be shocked if they looked deeply into the data on how poorly screening tests perform. It's why I skew towards lifestyle prevention.
@crnvr_invictus@Diet0Nutrition Can't do RCTs on something like LDL for causation on a dz that takes decades to manifest-population studies that work better here. And again and again, the answer is the same. Then we have the mechanism outlined for LDL creating vascular pathology. Makes a pretty solid argument.
@crnvr_invictus@Diet0Nutrition LDL DOES indeed cause vascular damage. Been reproduced through multiple studies. The link above is just one of many, but all talking about the same pathway. The mechanism is there combined with pretty much every observational study asking the question.
@crnvr_invictus@Diet0Nutrition You realize that LDL itself can cause vascular damage, right? So I would strongly suggest that elevated LDL is NOT consistent with better metabolic health & there are likely other markers not optimal. Something is missing--it always is.
Slingshot to better health in 60s: things I'd never do #12--antibiotics
Need to clarify something right out of the gate.
This recommendation is for me personally. Everyone has their own risk tolerance and belief... https://t.co/mBTWKRyB1q
Slingshot to better health in 60 seconds: things I never do #11--energy drinks
For a variety of reasons, I would never touch these things. And yet they seem to be consumed almost non-stop by a lot of people.
https://t.co/XbL2k5fvxK
@rice_gene3333@newstart_2024 Nothing to do with aflatoxin. Peanuts are high in arginine, which is used by the herpesvirus to form it's capsid. So, combine that with other triggers (like stress) and you would be prone to a flare up.
Slingshot to better health in 60s: things I'd never do #10 - ketchup
It's almost always a no-win scenario. Worst case scenario is straight up toxin laden tomatoes with high fructose corn syrup with mercury in it.
https://t.co/FyBXCJcxTO
It's crazy that we still allow this.
United States and New Zealand are the only two countries that I'm aware of that still allow this. There's a reason.
Providers hate it. https://t.co/kxuaCR9ys2
Slingshot to better health in 60s: things I'd never do #9--NOT exercise routinely
I have a lot of patients across all the age groups that don't do any regular exercise. https://t.co/EU3Xw8OUgF
@MohammedAlo Come on. ARR is like 1.5%. For a drug that is massively expensive, long list of side effects, and an unknown long-term safety profile. This drug 160x what Mother Nature designed (duration of GLP1 stim) I'm thinking $12K/year can buy a lot of alternative preventative measures.
Slingshot to better health in 60s: things I'd never do #8--skip stairs
Would never pass up the opportunity to go up a set of stairs. https://t.co/yRO7sCOs84
@LLicit_Tweet@DrSeanOMara LLicit - in the end, population studies like this likely (it is a massive study) give us the best answers. We can look at individual components of food compounds, but ultimately Mother Nature knew what she was doing when she puts these foods together.
@MohammedAlo Can't blame genetics-the whole"genetics loads the gun" saying. It absolutely makes it harder for some, but doesn't mean it has to happen. Analogy I use.. I'm Irish & likely have a strong genetic predisposition to alcoholism. Never touched alcohol. Will never develop alcoholism.
@MohammedAlo@TheShreddington It would make sense that CVD risk is NOT generic, but the link through MetS is. That being said, if someone changes lifestyle to match their genetics, why would they still need a dz label?