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Clinicians described the results as “one of the most amazing things I’ve ever seen.” An experimental once-daily oral drug called daraxonrasib has produced unprecedented outcomes in advanced pancreatic cancer, reducing the risk of death by 60% compared to standard chemotherapy.
In the Phase 3 RASolute 302 trial, daraxonrasib, a RAS(ON) multi-selective inhibitor developed by Revolution Medicines, nearly doubled median overall survival from 6.6–6.7 months with chemotherapy to 13.2 months in patients with previously treated metastatic pancreatic ductal adenocarcinoma. The trial, presented as a plenary session at the 2026 ASCO Annual Meeting, triggered a rare standing ovation from oncology experts.
Unlike traditional therapies, daraxonrasib effectively targets multiple KRAS variants and even wild-type RAS, offering broad applicability to the vast majority of pancreatic cancers. The drug was also far better tolerated, with only 1.2% of patients discontinuing treatment due to side effects, compared to 11.2% in the chemotherapy arm.
This represents a major advance for a disease long considered one of the most lethal in oncology. Experts are hailing daraxonrasib as a potential paradigm shift that could transform metastatic pancreatic cancer into a more manageable condition. The FDA has already granted expanded access for eligible patients.
[O’Reilly, E. M., et al. (2026). Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer. New England Journal of Medicine. DOI: 10.1056/NEJMoa2605555]
Clinicians described the results as “one of the most amazing things I’ve ever seen.” An experimental once-daily oral drug called daraxonrasib has produced unprecedented outcomes in advanced pancreatic cancer, reducing the risk of death by 60% compared to standard chemotherapy.
In the Phase 3 RASolute 302 trial, daraxonrasib, a RAS(ON) multi-selective inhibitor developed by Revolution Medicines, nearly doubled median overall survival from 6.6–6.7 months with chemotherapy to 13.2 months in patients with previously treated metastatic pancreatic ductal adenocarcinoma. The trial, presented as a plenary session at the 2026 ASCO Annual Meeting, triggered a rare standing ovation from oncology experts.
Unlike traditional therapies, daraxonrasib effectively targets multiple KRAS variants and even wild-type RAS, offering broad applicability to the vast majority of pancreatic cancers. The drug was also far better tolerated, with only 1.2% of patients discontinuing treatment due to side effects, compared to 11.2% in the chemotherapy arm.
This represents a major advance for a disease long considered one of the most lethal in oncology. Experts are hailing daraxonrasib as a potential paradigm shift that could transform metastatic pancreatic cancer into a more manageable condition. The FDA has already granted expanded access for eligible patients.
[O’Reilly, E. M., et al. (2026). Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer. New England Journal of Medicine. DOI: 10.1056/NEJMoa2605555]
I’m Blown Away in 😲AWE! One of My Beautiful Amazingly 🎁Gifted 💖Heart Daughters sent this to me today. KINGDOM WOWZERS! 🤩
My ❤️Heart & Soul Daughter~ Beautiful Terrific Tamika, I 💯 Absolutely 🥰Love this! Tears 😭 of ❤️Heart Gratitude & Thanksgiving! #LionessApostleDoc72New
A security camera captured the exact moment a child stopped in front of the image of Jesus, cleaned the area, said a prayer, and left.
His family raised him very well; he respects values and beliefs.
Honoring Christopher Plummer today and every day with his original vocal performance of “Edelweiss” from The Sound of Music – a chance to hear the song as he recorded it. 💛
"I don't think it was actually me [swimming]... It was God the whole time. I kept on praying, kept on praying. I said to God, 'I'll get baptized.'"
Austin Appelbee, a 13-year-old boy from Perth, Western Australia, heroically swam about 4 km through rough seas for four hours to get help after his family was swept far offshore, ultimately saving his mother and siblings. He openly credited God for giving him the strength, saying he prayed constantly, sang Christian songs in his mind, and promised to get baptized if he survived
Finished the entire Bible it’s been a 13 month word by word page by page no skimming journey. Humbled, enlightened and amazed at what I read and what I learned. I will rest and meditate on so much. I will begin it again.
In 1969, when many Black Americans were still prevented from swimming alongside whites, Mr. Rogers decided to invite Officer Clemmons to join him and cool his feet in a pool.
Remembering the life and legacy of Rev. Richard L. Smallwood (B.A. ’71, M.Div. ’04).
A founding voice of the Howard University Gospel Choir, a pioneer who reshaped gospel music, and a servant-leader whose compositions carried faith from sanctuary to world stage. His music gave comfort, courage, and praise across generations. Howard was his home, and his legacy will forever echo here. 🕊️🎶
Read More On The Dig: https://t.co/DIaik8WsMH
Let's be clear - Maduro is a very bad guy. But does it justify direct military intervention in Venezuela by the United States? There are new precedents being established here that could be used against us someday.