🚨 New ASCO Guidelines (2026): Well-Differentiated Thyroid Cancer
This is a major shift in how we treat RAI-refractory disease 👇
🧠 Step 1 is no longer MKI… it’s GENOMICS
👉 Test for: RET | NTRK | BRAF
If actionable → Targeted therapy FIRST
• RET → Selpercatinib (LIBRETTO-001)
• NTRK → Larotrectinib (pooled TRK trials) / Entrectinib (STARTRK)
• BRAF → Dabrafenib ± Trametinib (phase II BRAF studies)
🔥 Deep, durable responses > MKIs
📊 Signal strength
• NTRK inhibitors → ORR ~57–86%
• RET inhibitors → ORR ~79–90%
🧠 If no mutation (or not feasible)
👉 First-line MKI
• Lenvatinib (SELECT)
• Sorafenib (DECISION)
📊
SELECT → PFS 18.3 vs 3.6 mo
DECISION → PFS 10.8 vs 5.8 mo
👉 Lenvatinib preferred (higher ORR, longer PFS)
🧠 After progression
👉 Cabozantinib (COSMIC-311)
📊 PFS 11.0 vs 1.9 mo
🧠 Immunotherapy?
❌ Not upfront
👉 Consider only post-progression
Lenvatinib + Pembrolizumab (KEYNOTE-158 / ITOG study)
🧠 Chemotherapy
👉 Last-line only
🎯 Practice-changing shift
Old → Start MKI for all
New → Test → Target → Then MKI → Then Cabo
💡 Thyroid cancer is now a precision oncology disease
🔖 Save this before your next thyroid clinic
#OncoTwitter #MedTwitter #ThyroidCancer #PrecisionOncology @OncoAlert@myesmo@esmo_open@asco
क्या आपने कभी सुना है कि हँसी भी एक बीमारी का लक्षण हो सकती है? “लाफिंग एपिलेप्सी” में मरीजों को बार-बार अनियंत्रित हँसी के साथ दौरे आते हैं।
एम्स जोधपुर ने दुर्लभ “लाफिंग एपिलेप्सी” के इलाज में बड़ी सफलता हासिल की है। अत्याधुनिक न्यूनतम इनवेसिव सर्जरी से अब मरीज पूरी तरह दौरा मुक्त हैं।
राजस्थान का एकमात्र अस्पताल और देश का दूसरा एम्स जहाँ यह सुविधा उपलब्ध।
#AIIMSJodhpur #EpilepsyCare #AdvancedHealthcare #HealthcareInnovation
@JPNadda@mpprataprao@AnupriyaSPatel@MoHFW_INDIA
On National Immunization Day, vaccines are powerful tools in preventing certain cancers. Hepatitis B and HPV vaccines play a vital role in preventing liver and cervical cancers, highlighting the importance of immunization in cancer prevention.
#NationalImmunizationDay
A heartfelt tribute to the silent heroes of life.
At AIIMS Jodhpur, the “अंगदाता–स्मारिका” (Wall of Remembrance) was unveiled by Padma Shri awardee Shri Nilesh Vinodchandra Mandlewala, fondly known as the Organ Man of India.
With 11 cadaveric donors and 33 organs harvested (including 3 hearts), this initiative honors the noble legacy of organ donors.
Families of donors shared emotional experiences, inspiring many to pledge life beyond life.
#OrganDonation #AIIMSJodhpur #GiftOfLife #SaveLives
@JPNadda@mpprataprao@AnupriyaSPatel@MoHFW_INDIA
Hpv Vaccination Campaign Rajasthan: PM to launch HPV vaccination drive in Ajmer | Jaipur News - The Times of India https://t.co/iXYopBsFsn
Historical move
#Cervicalcancer remains a major public health concern in India. In 2022, the country reported an estimated 127,526 new cases and 79,906 deaths from the disease. Prevention is the cure. #HPVVaccine (GLOBOCON, 2022 India Fact Sheet)
AIIMS Jodhpur urges parents to participate voluntarily in campaign to be launched nationwide by Hon’ble Prime Minister Shri @narendramodi ji in Ajmer on 28 February 2026.
@JPNadda@mpprataprao@AnupriyaSPatel@MoHFW_INDIA@DhrHtain
📣 EXCITING ANNOUNCEMENT from the Indian Journal of Surgical Oncology, the official pubmed indexed journal of IASO
Dissertation Special Issue for
Young Surgical Oncologists ‼️
Submit your Manuscript Today!!!!
Do not miss this unique opportunity to be published with IJSO 🥳
ICG reduced odds of AL by 58% (9% vs. 15.5%; OR 0.42, 95% CI: 0.26–0.70; I²=42%), with an absolute risk difference of 6.5% (95% CI: 3.3–9.7) and a number needed to treat (NNT) of 15 (10–30)
@ISDE_net@IASO_IJSOonline@aiims_jodhpur@aiims_newdelhi#LandMark Meta-analysis